Protein Information

Name BMP4
Synonyms BMP 2B; ZYME; BMP 4; BMP2B; BMP2B1; BMP4; Bone morphogenetic protein 2B; Bone morphogenetic protein 4…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19895205 Wang C, Yin S, Cen L, Liu Q, Liu W, Cao Y, Cui L: Differentiation of Adipose-Derived Stem Cells into Contractile Smooth Muscle Cells Induced by Transforming Growth Factor-beta1 and Bone Morphogenetic Protein-4. Tissue Eng Part A. 2010 Jan 17.

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19819545 Wang C, Cen L, Yin S, Liu Q, Liu W, Cao Y, Cui L: A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells. Biomaterials. 2010 Feb;31(4):621-30. Epub 2009 Oct 12.


With the induction of transforming growth factor-beta1 (TGF-beta1) and bone morphogenetic protein-4 (BMP4) in combination for 7 days, hASCs were found to acquire an SMC phenotype characterized by the expression of SMC-related markers including smooth muscle alpha actin (alpha-SMA), calponin, and smooth muscle myosin heavy chain (SM-MHC).
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17570339 Zhao C, Hosoya A, Kurita H, Hu T, Hiraga T, Ninomiya T, Yoshiba K, Yoshiba N, Takahashi M, Kurashina K, Ozawa H, Nakamura H: Immunohistochemical study of hard tissue formation in the rat pulp cavity after tooth replantation. Arch Oral Biol. 2007 Oct;52(10):945-53. Epub 2007 Jun 13.


Cells positive for BMP4, Smad4, Runx2, and Osterix were found around the blood vessels of the root apex at 5 days.
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19819988 Chang SF, Chang TK, Peng HH, Yeh YT, Lee DY, Yeh CR, Zhou J, Cheng CK, Chang CA, Chiu JJ: BMP-4 induction of arrest and differentiation of osteoblast-like cells via p21 CIP1 and p27 KIP1 regulation. Mol Endocrinol. 2009 Nov;23(11):1827-38. Epub 2009 Oct 9.

We investigated the roles of bone morphogenetic protein (BMP)-4, an important stimulator of osteoblast differentiation and bone formation, in regulating cell cycle distribution in four osteoblast-like cell lines and mouse primary osteoblasts, and the underlying mechanisms.
Using specific small interfering RNA (siRNA), we found that BMP-4-induced G (0)/G (1) arrest, and p21 (CIP1) and p27 (KIP1) expressions were mediated by BMP receptor type IA (BMPRIA)-specific Sma- and Mad-related protein (Smad) 1/5.
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