| Name | E cadherin |
|---|---|
| Synonyms | Arc 1; CAM 120/80; CD324; CD324 antigen; CDH 1; CDH1; CDHE; Cadherin 1… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20349724 | Zhou J, Wang F, Lu H, Zhang Y: [Impact of salvianolic acid-B on TGF-beta1-induced HK-2 epithelial-mesenchymal transition]. Zhongguo Zhong Yao Za Zhi. 2010 Jan;35(1):89-93. Western blot and immunofluorescent microscopy were used to analyze the expression of E-cadherin and alpha-smooth muscle actin (alpha-SMA) in HK2. |
2(0,0,0,2) | Details |
| 19101622 | Xie XS, Yang M, Liu HC, Zuo C, Li HJ, Fan JM: Ginsenoside Rg1, a major active component isolated from Panax notoginseng, restrains tubular epithelial to myofibroblast transition in vitro. J Ethnopharmacol. 2009 Feb 25;122(1):35-41. Epub 2008 Dec 3. The morphology of tubular epithelial-myofibroblast transition was observed through light microscope and transmission electron microscopy. alpha-SMA and E-cadherin are two markers of tubular epithelial-myofibroblast transition, their protein expressions were assessed by immunohistochemistry and western blot analysis. |
2(0,0,0,2) | Details |
| 19252942 | Zhang M, Zhang Z, Pan HY, Wang DX, Deng ZT, Ye XL: TGF-beta1 induces human bronchial epithelial cell-to-mesenchymal transition in vitro. Lung. 2009 May-Jun;187(3):187-94. Epub 2009 Feb 28. The expression of alpha-SMA (alpha-smooth muscle actin) and the epithelial cell marker E-cadherin were detected in those 16HBE-14o cells after TGF-beta1 stimulation for 72 h, using immunostaining and RT-PCR. |
2(0,0,0,2) | Details |
| 18550647 | Ardura JA, Berruguete R, Ramila D, Alvarez-Arroyo MV, Esbrit P: Parathyroid hormone-related protein interacts with vascular endothelial growth factor to promote fibrogenesis in the obstructed mouse kidney. Am J Physiol Renal Physiol. 2008 Aug;295(2):F415-25. Epub 2008 Jun 11. In vitro, PTHrP-(1-36) increased (maximal 2-fold vs. basal, at 100 nM) alpha-SMA and ILK protein expression and decreased E-cadherin protein levels in renal tubuloepithelial mouse cortical tubule and normal rat kidney (NRK) 52E cells. |
1(0,0,0,1) | Details |
| 20197616 | Liu X, Zhang H, Sun J, Yu X, Liao Q: [Effect of TGF-beta1 on epithelial-mesenchymal transition of rat peritoneal mesothelial cells and its mechanism.]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Feb;35(2):159-64. The mRNA and protein expression levels of E-cadherin, alpha-smooth muscle actin (alpha-SMA) and collagenIwere measured by RT-PCR and Western blot, respectively. |
2(0,0,0,2) | Details |
| 20340130 | Vered M, Dayan D, Yahalom R, Dobriyan A, Barshack I, Bello IO, Kantola S, Salo T: Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma. Int J Cancer. 2010 Mar 25. Triple immunostaining in RLNs was used to highlight the carcinoma cells (E-cadherin and Ki-67) and their relationship to the CAFs (alpha-SMA).We found that metastatic RLNs hosted CAFs similarly as in pair-matched primary tumors. |
2(0,0,0,2) | Details |
| 18988308 | Xie XS, Yang M, Liu HC, Zuo C, Li Z, Deng Y, Fan JM: Influence of ginsenoside Rg1, a panaxatriol saponin from Panax notoginseng, on renal fibrosis in rats with unilateral ureteral obstruction. J Zhejiang Univ Sci B. 2008 Nov;9(11):885-94. Histological examination demonstrated that ginsenoside Rg1 significantly inhibited interstitial fibrosis including tubular injury as well as collagen deposition. alpha-smooth muscle actin (alpha-SMA) and E-cadherin are two markers of tubular epithelial-myofibroblast transition (TEMT). |
2(0,0,0,2) | Details |
| 20089260 | Campbell MT, Hile KL, Zhang H, Asanuma H, Vanderbrink BA, Rink RR, Meldrum KK: Toll-Like Receptor 4: A Novel Signaling Pathway During Renal Fibrogenesis. J Surg Res. 2009 Oct 23. The kidneys were harvested and tissues were analyzed for TLR4 expression (Western blot; RTPCR), E-cadherin and alpha smooth muscle actin (alpha-SMA) expression (Western blot), fibroblast accumulation (fibroblast specific protein (FSP-1+) staining), renal fibrosis (collagen I RTPCR, total collagen assay, Masson's trichrome staining), cytokine gene expression (tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 (TGF-beta1) RTPCR), and pSMAD2 and integrin alpha1 expression (Western blot). |
2(0,0,0,2) | Details |
| 17933841 | Li M, Hering-Smith KS, Simon EE, Batuman V: Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells. Nephrol Dial Transplant. 2008 Mar;23(3):860-70. Epub 2007 Oct 12. Using semiquantitative immunoblotting and RT-PCR, we observed that the expression of E-cadherin decreased after 24 h, while the expression of alpha-SMA increased in PTEC after continuous exposure to kappa-LCs. |
2(0,0,0,2) | Details |
| 18976289 | Djamali A, Vidyasagar A, Adulla M, Hullett D, Reese S: Nox-2 is a modulator of fibrogenesis in kidney allografts. Am J Transplant. 2009 Jan;9(1):74-82. Epub 2008 Oct 31. Allografts treated with Nox inhibitors (DPI or apocynin) for 1 week showed reduced fibronectin and phospho-Smad2 and increased E-cadherin levels. |
2(0,0,0,2) | Details |
| 18087244 | Banh A, Deschamps PA, Vijayan MM, Sivak JG, West-Mays JA: The role of Hsp70 and Hsp90 in TGF-beta-induced epithelial-to-mesenchymal transition in rat lens epithelial explants. Mol Vis. 2007 Nov 29;13:2248-62. Immunofluorescence staining for alpha-smooth muscle actin (alpha-SMA), F-actin, and E-cadherin was also used to determine EMT and fibrotic plaque formation in the lens epithelial explants. |
2(0,0,0,2) | Details |
| 19543302 | Yan JD, Yang S, Zhang J, Zhu TH: BMP6 reverses TGF-beta1-induced changes in HK-2 cells: implications for the treatment of renal fibrosis. Acta Pharmacol Sin. 2009 Jul;30(7):994-1000. Epub 2009 Jun 22. Cell proliferation, morphology, and expression levels of alpha-SMA and E-cadherin were assessed by cell viability, microscopy, and Western blot assays, respectively. |
2(0,0,0,2) | Details |
| 19053028 | Lu Y, Liu C, Miao X, Xu K, Wu X, Liu C: Increased expression of myo-inositol oxygenase is involved in the tubulointerstitial injury of diabetic nephropathy. Exp Clin Endocrinol Diabetes. 2009 Jun;117(6):257-65. Epub 2008 Dec 3. In addition, alpha-smooth muscle actin (alpha-SMA) and fibronectin levels were increased and E-cadherin levels decreased in the same diabetic kidneys. |
2(0,0,0,2) | Details |
| 17959033 | Liu BC, Xia HL, Wu JN, Zhang XL, Liu DG, Gong YX: Influence of irbesartan on expression of ILK and its relationship with epithelial-mesenchymal transition in mice with unilateral ureteral obstruction. Acta Pharmacol Sin. 2007 Nov;28(11):1810-8. The expression of alpha-smooth muscle actin (alpha-SMA) was significantly increased, while E-cadherin was decreased in mice with UUO at d 3 after the surgery. |
2(0,0,0,2) | Details |
| 20015471 | Wang QL, Yuan JL, Tao YY, Zhang Y, Liu P, Liu CH: Fuzheng Huayu recipe and reverse renal interstitial fibrosis through counteracting TGF-beta1-induced epithelial-to-mesenchymal transition. J Ethnopharmacol. 2010 Feb 17;127(3):631-40. Epub 2009 Dec 16. Protein expression and the location of Smad3 in kidney was assayed by immunohistochemistry, E-cadherin, cytokeratin 18 (CK-18), alpha-SMA and TGF-beta1 by immunofluorescent stain. |
2(0,0,0,2) | Details |
| 19460706 | He F, Yu L, Tong JR, Luo ZM, Zhu QZ, Wang Y, Zhang JL: [Role of integrin-linked kinase in renal tubular epithelial-mesenchymal transition and the regulatory effect of urokinae on its expression in mice with obstructive nephropathy]. Nan Fang Yi Ke Da Xue Xue Bao. 2009 May;29(5):909-13. The expression of ILK in the renal tissues of the rats was examined by immunofluorescence staining and Western blotting, and the expression of E-cadherin was detected by immunohistochemistry. |
2(0,0,0,2) | Details |
| 18070611 | Wang X, Nie J, Zhou Q, Liu W, Zhu F, Chen W, Mao H, Luo N, Dong X, Yu X: Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-beta during the process of epithelial to mesenchymal transition in rat proximal epithelial cells. Biochim Biophys Acta. 2008 Jan;1782(1):51-9. Epub 2007 Nov 19. Forced expression of exogenous Par-3 into rat proximal epithelial cells (NRK52E) led to a drastic blockage of TGF-beta1-induced E-cadherin suppression and alpha-SMA induction. |
2(0,0,0,2) | Details |
| 19082432 | Fang KY, Shi MJ, Xiao Y, Gui HZ, Guo B, Zhang GZ: [p38 MAPK mediates high -induced renal tubular epithelial-mesenchymal transition.]. Sheng Li Xue Bao. 2008 Dec 25;60(6):759-66. The expressions of p38 MAPK, p-p38 MAPK, Snail1, transforming growth factor-beta1 (TGF-beta1), alpha-smooth muscle actin (alpha-SMA) and E-cadherin protein and mRNA were detected by immunocytochemical staining, Western blot and RT-PCR. |
2(0,0,0,2) | Details |
| 18596079 | Vidyasagar A, Reese S, Acun Z, Hullett D, Djamali A: HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis. Am J Physiol Renal Physiol. 2008 Sep;295(3):F707-16. Epub 2008 Jul 2. Immunofluorescence studies showed that HSP27 costained with TGF-beta1, alpha-SMA, and E-cadherin in areas of tubulointerstitial injury. |
6(0,0,0,6) | Details |
| 20348013 | Saad S, Stanners SR, Yong R, Tang O, Pollock CA: NOTCH MEDIATED EPITHELIAL TO MESENCHYMAL TRANSFORMATION IS ASSOCIATED WITH INCREASED EXPRESSION OF THE SNAIL TRANSCRIPTION FACTOR. Int J Biochem Cell Biol. 2010 Mar 25. The expressions of Notch 1, Snail, E-cadherin and alpha-smooth muscle actin (alpha-SMA) were determined by Western blot. |
5(0,0,0,5) | Details |
| 20006464 | Wu G, Tu Y, Jia R: The influence of fasudil on the epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells from diabetic rats. Biomed Pharmacother. 2010 Feb;64(2):124-9. Epub 2009 Oct 23. Expression of ROCK1, alpha-SMA, E-cadherin and the distribution of beta-catenin in rat renal cortex were revealed by immunohistochemistry. |
5(0,0,0,5) | Details |
| 19420758 | Yao G, Xu L, Wu X, Xu L, Yang J, Chen H: Preventive effects of salvianolic acid B on transforming growth factor-beta1-induced epithelial-to-mesenchymal transition of human kidney cells. Biol Pharm Bull. 2009 May;32(5):882-6. It was partially through modulating alpha-smooth muscle actin (SMA) increase and E-cadherin reduction. |
1(0,0,0,1) | Details |
| 19375841 | Yoo YA, Kang MH, Kim BS, Kim JS, Seo JH: Sustained co-cultivation with human placenta-derived MSCs enhances ALK5/Smad3 signaling in human breast epithelial cells, leading to EMT and differentiation. Differentiation. 2009 Jun;77(5):450-61. Epub 2009 Apr 17. We show that after co-culture with hPMSCs, human mammary epithelial cell lines (MCF-10F and HEMC) underwent significant morphologic alterations and a dramatic increase in ductal-alveolar branching, which was accompanied by a decrease or loss of the epithelial marker E-cadherin and a gain of the mesenchymal markers, alpha-SMA and vimentin. |
1(0,0,0,1) | Details |
| 19957515 | Xu YF, Wan JX, Jiang DW: [Effects of bone morphogenic protein-7 on transdifferentiation and the expression of connective tissue growth factor of human renal tubular epithelial cells induced by transforming growth factor-beta1]. Zhonghua Yi Xue Za Zhi. 2009 Jun 16;89(23):1639-44. RT-PCR and Western blot were used to determine the mRNA and protein expression of alpha-SMA, E-cadherin and CTGF. |
4(0,0,0,4) | Details |
| 17951996 | Liu BC, Li MX, Zhang JD, Liu XC, Zhang XL, Phillips AO: Inhibition of integrin-linked kinase via a siRNA expression plasmid attenuates connective tissue growth factor-induced human proximal tubular epithelial cells to mesenchymal transition. Am J Nephrol. 2008;28(1):143-51. Epub 2007 Oct 19. METHODS: The expression of alpha-smooth muscle actin (alpha-SMA) and E-cadherin upon the stimulation by recombinant human CTGF (rhCTGF) in cultured human tubular epithelial cell line (HK-2) was detected by real-time RT-PCR and Western blot. |
4(0,0,0,4) | Details |
| 20067910 | Loureiro J, Schilte M, Aguilera A, Albar-Vizcaino P, Ramirez-Huesca M, Perez-Lozano ML, Gonzalez-Mateo G, Aroeira LS, Selgas R, Mendoza L, Ortiz A, Ruiz-Ortega M, van den Born J, Beelen RH, Lopez-Cabrera M: BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure. Nephrol Dial Transplant. 2010 Apr;25(4):1098-108. Epub 2010 Jan 12. METHODS: Epitheliod or non-epitheliod MC were analysed for the expression of BMP-7, TGF-beta1, activated Smads, epithelial cadherin (E-cadherin), collagen I, alpha smooth muscle cell actin (alpha-SMA) and vascular endothelial growth factor (VEGF) using standard procedures. |
1(0,0,0,1) | Details |
| 19952797 | Liu ZJ, Zhang LJ, Zhao Q, Li QW, Wang EB, Ji SJ, Shu H: Pediatric synovial sarcoma of the sacrum: a case report. J Pediatr Orthop B. 2010 Mar;19(2):207-10. CK, CK7, CK1, CK3, CK8, CK19, Bcl-2, E-cadherin, ki-67, P53, SMA, CD99, CD56, S-100, vimentin, and epithelial membrane antigen were positive. |
1(0,0,0,1) | Details |
| 19193779 | Yu MA, Shin KS, Kim JH, Kim YI, Chung SS, Park SH, Kim YL, Kang DH: HGF and BMP-7 ameliorate high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelium. J Am Soc Nephrol. 2009 Mar;20(3):567-81. Epub 2009 Feb 4. We found that high concentrations of induced epithelial-to-mesenchymal transition (EMT) of HPMC, suggested by decreased expression of E-cadherin and increased expression of alpha-smooth muscle actin, fibronectin, and type I collagen and by increased cell migration. |
1(0,0,0,1) | Details |
| 19887789 | Oh EJ, Ryu HM, Choi SY, Yook JM, Kim CD, Park SH, Chung HY, Kim IS, Yu MA, Kang DH, Kim YL: Impact of low degradation product /lactate-buffered dialysis solution on the epithelial-mesenchymal transition of peritoneum. Am J Nephrol. 2010;31(1):58-67. Epub 2009 Nov 4. EMT was assessed with alpha-smooth muscle actin (alpha-SMA) and E-cadherin. |
4(0,0,0,4) | Details |
| 20193281 | Xia YG, Wu XH, Yin ZK, Luo CL, Zhang JM, Cheng HL: [Effects of silencing transforming growth factor-beta1 by RNAi upon transdifferentiation of renal allograft tubular epithelial cells in rats]. Zhonghua Yi Xue Za Zhi. 2009 Dec 1;89(44):3151-5. The gene transcriptional levels of TGF-beta1 and E-cadherin were detected by RT-PCR and the protein variation of E-cadherin was examined by Western blotting. |
4(0,0,0,4) | Details |
| 20015943 | Yadav A, Vallabu S, Kumar D, Ding G, Charney DN, Chander PN, Singhal PC: HIVAN phenotype: consequence of epithelial mesenchymal transdifferentiation. Am J Physiol Renal Physiol. 2010 Mar;298(3):F734-44. Epub 2009 Dec 16. Occurrence of EMT was also supported by diminished expression of E-cadherin by renal epithelial cells in Tg26 mice. |
1(0,0,0,1) | Details |
| 19154323 | Xu G, Liu A, Liu X: induces collagen synthesis via activation of extracellular signal-regulated kinase 1 and 2 in renal proximal tubules. Nephrology. 2008 Dec;13(8):694-701. ERK1/2 activation, alpha-smooth muscle actin (alpha-SMA), and E-cadherin were also detected by western blot. |
1(0,0,0,1) | Details |
| 18679024 | Ng YY, Chen YM, Tsai TJ, Lan XR, Yang WC, Lan HY: Pentoxifylline inhibits transforming growth factor-beta signaling and renal fibrosis in experimental crescentic glomerulonephritis in rats. Am J Nephrol. 2009;29(1):43-53. Epub 2008 Aug 5. This was associated with tubular epithelial-myofibroblast transition as evident by de novo expression of alpha-SMA and a loss of E-cadherin on damaged tubular epithelial cells. |
1(0,0,0,1) | Details |
| 20096777 | Shin DH, Park HM, Jung KA, Choi HG, Kim JA, Kim DD, Kim SG, Kang KW, Ku SK, Kensler TW, Kwak MK: The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis. Free Radic Biol Med. 2010 Apr 15;48(8):1051-63. Epub 2010 Jan 22. Pretreatment of rat tubular epithelial NRK-52E cells with an activator of NRF2, could prevent EMT gene changes such as the loss of E-cadherin and the increase in alpha-smooth muscle actin (alpha-SMA) expression. |
1(0,0,0,1) | Details |
| 20112425 | Tang DJ, Dong SS, Ma NF, Xie D, Chen L, Fu L, Lau SH, Li Y, Li Y, Guan XY: Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. Hepatology. 2009 Nov 30. Further study found that EIF5A2 was able to induce epithelial-mesenchymal transition (EMT), a key event in tumor invasion and metastasis, characterized by down-regulation of epithelial markers (E-cadherin and beta-catenin) and up-regulation of mesenchymal markers (fibronectin, N-cadherin, alpha-SMA, and vimentin). |
1(0,0,0,1) | Details |
| 19056781 | Dudas PL, Argentieri RL, Farrell FX: BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells. Nephrol Dial Transplant. 2009 May;24(5):1406-16. Epub 2008 Dec 4. METHODS: EMT was determined by quantitative real-time PCR analysis of e-cadherin, vimentin, CTGF and TGF-beta1 transcript expression and immunocytochemical analysis of ZO-1 and alpha-smooth muscle actin (alpha-SMA) protein expression following TGF-beta1 treatment in RPTEC and HK-2 cells. |
4(0,0,0,4) | Details |
| 18288368 | Fang KY, Lou JL, Xiao Y, Shi MJ, Gui HZ, Guo B, Zhang GZ: [Transforming growth factor-beta1 and Snail1 mediate tubular epithelial-mesenchymal transition in diabetic rats.]. Sheng Li Xue Bao. 2008 Feb 25;60(1):125-34. Immunohistochemical staining and (or) Western blot were employed to determine the expressions of TGF-beta1, Snail1, E-cadherin, alpha-smooth muscle actin (alpha-SMA) and fibronectin (FN) proteins. |
4(0,0,0,4) | Details |
| 20157767 | Li Y, Zhang J, Fang L, Luo P, Peng J, Du X: Lefty A attenuates the TGF-beta1-induced epithelial to mesenchymal transition of human renal proximal epithelial tubular cells. Mol Cell Biochem. 2010 Feb 16. The results show that stimulation with TGF-beta1 led to EMT including cell morphology changes, Smad2/3 signaling pathway activation, increased alpha-SMA, collagen type I, and CTGF expression, and decreased E-cadherin expression in mock-transfected HK-2 cells. |
1(0,0,0,1) | Details |
| 19198871 | Franz M, Spiegel K, Umbreit C, Richter P, Codina-Canet C, Berndt A, Altendorf-Hofmann A, Koscielny S, Hyckel P, Kosmehl H, Virtanen I, Berndt A: Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma. Histochem Cell Biol. 2009 May;131(5):651-60. Epub 2009 Feb 6. Additionally, the influence of TGF beta 1 and EGF on Snail, E-cadherin, vimentin, and alpha SMA expression was analysed in two OSCC cell lines. |
1(0,0,0,1) | Details |
| 19741012 | Veerasamy M, Nguyen TQ, Motazed R, Pearson AL, Goldschmeding R, Dockrell ME: Differential regulation of E-cadherin and alpha-smooth muscle actin by BMP 7 in human renal proximal tubule epithelial cells and its implication in renal fibrosis. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1238-48. Epub 2009 Sep 9. |
4(0,0,0,4) | Details |
| 19557718 | Xu Y, Wan J, Jiang D, Wu X: BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition in human renal proximal tubular epithelial cells. J Nephrol. 2009 May-Jun;22(3):403-10. The expression of alpha-smooth muscle actin (alpha-SMA), E-cadherin, fibronectin, collagen I and connective tissue growth factor (CTGF) was analyzed by immunofluorescence, reverse transcriptase polymerase chain reaction and Western blotting. |
3(0,0,0,3) | Details |
| 17923018 | Xu GP, Li QQ, Cao XX, Chen Q, Zhao ZH, Diao ZQ, Xu ZD: [Effect of Smad7 on transforming growth factor-beta1-induced alveolar epithelial to mesenchymal transition]. Zhonghua Yi Xue Za Zhi. 2007 Jul 17;87(27):1918-23. The expression of the markers of the epithelial cells, including E-cadherin and cytokeratin-19 (CK19), and markers of mesenchymal cells, including fibronectin (FN), vimentin, and alpha-smooth muscle actin (alpha-SMA) were assayed using Western blotting and real-time PCR. |
1(0,0,0,1) | Details |
| 19801454 | Zhou G, Dada LA, Wu M, Kelly A, Trejo H, Zhou Q, Varga J, Sznajder JI: Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1. Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1120-30. Epub 2009 Oct 2. We found that hypoxia induced the expression of alpha-smooth muscle actin (alpha-SMA) and vimentin and decreased the expression of E-cadherin in transformed and primary human, rat, and mouse AEC, suggesting that hypoxia induces EMT in AEC. |
1(0,0,0,1) | Details |
| 19900406 | Du R, Huang C, Bi Q, Zhai Y, Xia L, Liu J, Sun S, Fan D: URG11 mediates hypoxia-induced epithelial-to-mesenchymal transition by modulation of E-cadherin and beta-catenin. Biochem Biophys Res Commun. 2010 Jan 1;391(1):135-41. Epub 2009 Nov 11. |
3(0,0,0,3) | Details |
| 19158077 | Huang WY, Li ZG, Rus H, Wang X, Jose PA, Chen SY: RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells. J Biol Chem. 2009 Apr 3;284(14):9426-32. Epub 2009 Jan 21. However, TGF-beta stimulation markedly activates RGC-32 while inducing an EMT, as shown by the induction of smooth muscle alpha-actin (alpha-SMA) and extracellular matrix proteins collagen I and fibronectin, as well as the reduction of epithelial marker E-cadherin. |
3(0,0,0,3) | Details |
| 20171171 | Mariasegaram M, Tesch GH, Verhardt S, Hurst L, Lan HY, Nikolic-Paterson DJ: Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells. Biochem Biophys Res Commun. 2010 Mar 19;393(4):855-9. Epub 2010 Feb 18. A rat tubular epithelial cell line (NRK52E) was stably transfected with a Lefty expression plasmid (52E-Lefty) or control plasmid (52E-Control). 52E-Control cells underwent TGF-beta1 induced EMT with up-regulation of alpha-smooth muscle actin (alpha-SMA), down-regulation of E-cadherin, and transition to an elongated fibroblast-like morphology. |
1(0,0,0,1) | Details |
| 19575449 | Yovchev MI, Zhang J, Neufeld DS, Grozdanov PN, Dabeva MD: Thymus cell antigen-1-expressing cells in the oval cell compartment. Hepatology. 2009 Aug;50(2):601-11. Subcloning of Thy-1 (+) cells from OC-activated livers yield Thy-1 (+) fibroblastic cells and a population of E-cadherin (+) mesenchymal cells that gradually discontinue expression of Thy-1 and begin to express cytokeratins. |
1(0,0,0,1) | Details |
| 17633463 | Zhang MZ, Zhang MY, Zhao S, Duan JZ, Zhang YQ, Zuo CX, Cheng XY, Duan HJ: [Effect of JAK/STAT pathway activation on high -induced transdifferentiation in renal proximal tubular epithelial cells]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007 Jun;29(3):364-9. The protein expressions of STAT1, STAT3, p-STAT1, and p-STAT3 and the expressions of alpha-SMA and E-Cadherin were observed by Western blot. |
3(0,0,0,3) | Details |
| 19781193 | Ding Z, Chen ZS, Chen XL, Guo H, Gong NQ: [Inducing of epithelial mesenchymal transition of HK-2 cells by connective tissue growth factor in vitro]. Zhonghua Bing Li Xue Za Zhi. 2009 Jul;38(7):462-5. Direct immunofluorescence staining and immunohistochemistry were used to evaluate the E-cadherin, Vimentin, alpha-SMA and ERK2 in cells. |
3(0,0,0,3) | Details |
| 19180920 | He CM, Zheng FL, Lian YG, Liu YP: [Relationship between the effect of vascular endothelial growth factor on epithelial-mesenchymal transition of HK-2 cells and the expressions of bone morphogenetic protein-7 and inhibitor of DNA binding/differentiation]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008 Dec;30(6):703-10. METHODS: The cultured HK-2 cells were co-treated with transforming growth factor-beta1 (TGF-beta1) (5 ng/ml) and VEGF165 (0.1, 1, 10, 100 ng/ml), or with TGF-beta1 (5 ng/ml) and VEGF receptor-1 neutralized antibody (10 microg/ ml), and were also co-treated with TGF-beta1 (5 ng/ml) and VEGF165 (100 ng/ml) with or without activin receptor-like kinase 6 (Alk6)/Fc Chimera (2 microg/ml, to neutralize endogenous BMP-7) for 48 hours. mRNA and protein expressions of alpha-smooth muscle actin (alpha-SMA), E-cadherin, BMP-7, Id2 and Id3 of HK-2 cells were assessed with double-stain immunocytochemistry, real-time PCR and Western blot respectively. |
3(0,0,0,3) | Details |
| 19597127 | Lepparanta O, Pulkkinen V, Koli K, Vahatalo R, Salmenkivi K, Kinnula VL, Heikinheimo M, Myllarniemi M: Transcription Factor GATA-6 is Expressed in Quiescent Myofibroblasts in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2009 Jul 13. In cultured A549 lung epithelial cells, the induction of GATA-6 by TGF-beta1 resulted in simultaneous expression of alpha-SMA and decrease of E-cadherin. |
1(0,0,0,1) | Details |
| 19259356 | Chea SW, Lee KB: TGF-beta mediated epithelial-mesenchymal transition in autosomal dominant polycystic kidney disease. Yonsei Med J. 2009 Feb 28;50(1):105-11. Epub 2009 Feb 24. Cystic tubular epithelial cells in ADPKD lost epithelial marker (E-cadherin) and expressed mesenchymal markers (alpha-SMA, vimentin). |
1(0,0,0,1) | Details |
| 18790236 | Luo GH, Lu YP, Song J, Yang L, Shi YJ, Li YP: Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy. Transplant Proc. 2008 Sep;40(7):2365-9. The expressions of collagen I and IV, and alpha-SMA were also significantly downregulated and E-cadherin was lost in the siRNA versus the NS and control siRNA groups at 8 weeks. |
1(0,0,0,1) | Details |
| 17596522 | Zhang A, Jia Z, Guo X, Yang T: induces epithelial-mesenchymal transition via ROS of mitochondrial origin. Am J Physiol Renal Physiol. 2007 Sep;293(3):F723-31. Epub 2007 Jun 27. Exposure of human renal proximal tubular cells to Aldo for 48 h dose dependently induced EMT as evidenced by conversion to the spindle-like morphology, loss of E-cadherin, and de novo expression of alpha-smooth muscle actin (SMA); the effect was noticeable at 50 nM and maximal at 100 nM. |
3(0,0,0,3) | Details |
| 18552272 | Liu Q, Mao H, Nie J, Chen W, Yang Q, Dong X, Yu X: Transforming growth factor {beta}1 induces epithelial-mesenchymal transition by activating the JNK-Smad3 pathway in rat peritoneal mesothelial cells. Perit Dial Int. 2008 Jun;28 Suppl 3:S88-95. The messenger RNA levels and protein expression of alpha-smooth muscle actin (alpha-SMA), E-cadherin, and collagen I were determined with reverse transcriptase polymerase chain reaction and Western blotting respectively. |
3(0,0,0,3) | Details |
| 19066060 | Xie XS, Liu HC, Li HJ, Fan JM: [Ginsenoside R (g1) inhibit transdifferentiation in rat renal tubular epethelial cells induced by TGF-beta1]. Zhongguo Zhong Yao Za Zhi. 2008 Sep;33(17):2136-41. The morphology of tubular epithelial-myofibroblast transdifferentiation induced by TGF-beta1 was observed through light microscope. alpha-SMA and E-cadherin protein expression were assessed by immunohistochemistry and western blot analyses. alpha-SMA, collagen I and and fibronectin gene expression were assessed by real-time quantitative chain reaction. |
3(0,0,0,3) | Details |
| 18455002 | Carvajal G, Droguett A, Burgos ME, Aros C, Ardiles L, Flores C, Carpio D, Ruiz-Ortega M, Egido J, Mezzano S: Gremlin: a novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy. Transplant Proc. 2008 Apr;40(3):734-9. Gremlin, BMP-7, E-cadherin, and alpha-smooth muscle actin (alpha-SMA) proteins were evaluated by immunohistochemistry and Smad3 activation by Southwestern. |
1(0,0,0,1) | Details |
| 20047646 | Reese S, Vidyasagar A, Jacobson L, Acun Z, Esnault S, Hullett D, Malter JS, Djamali A: The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model. Fibrogenesis Tissue Repair. 2010 Jan 4;3:1. Juglone also reduced EMT (alpha-SMA and E-cadherin dual staining) and oxidative stress (Mn superoxide dismutase (SOD) and NAPDH oxidase 2 (Nox-2) dual staining) in the obstructed kidney. |
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| 18992195 | Huang YJ, Wang ZH, Zhang JB, Liang L, Chen F, Zhao JH: [Smad7 instead of Smad6 blocks epithelial-mesenchymal transition induced by TGF-beta in human renal proximal tubule epithelial cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Nov;24(11):1074-8. The levels of phospho-Smad2, alpha-smooth muscle actin (alpha-SMA) and E-cadherin proteins were measured by Western blot. |
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| 19816049 | Xu Y, Wan J, Jiang D, Wu X: BMP-7 blocks the cyclosporine-A-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells. Nephron Exp Nephrol. 2010;114(1):e23-31. Epub 2009 Oct 9. The expression of alpha-smooth muscle actin (alpha-SMA), E-cadherin, collagen type I and CTGF was analyzed by immunofluorescence, RT-PCR, and Western blot. |
2(0,0,0,2) | Details |
| 18929865 | Luo GH, Lu YP, Yang L, Song J, Shi YJ, Li YP: Epithelial to mesenchymal transformation in tubular epithelial cells undergoing anoxia. Transplant Proc. 2008 Oct;40(8):2800-3. Immunohistochemistry and flow cytometry were used to detect expression changes of E-cadherin, alpha-smooth muscle actin (SMA), types I and IV collagen, all of which are involved in TEC, EMT. |
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| 19411308 | Nasreen N, Mohammed KA, Mubarak KK, Baz MA, Akindipe OA, Fernandez-Bussy S, Antony VB: Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-beta1 in vitro. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L115-24. Epub 2009 May 1. Cytokeratin-8 and E-cadherin expression decreased whereas vimentin remained unchanged over time in transforming PMC. |
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| 19190330 | Khawam K, Giron-Michel J, Gu Y, Perier A, Giuliani M, Caignard A, Devocelle A, Ferrini S, Fabbi M, Charpentier B, Ludwig A, Chouaib S, Azzarone B, Eid P: Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition. Cancer Res. 2009 Feb 15;69(4):1561-9. Epub 2009 Feb 3. In these cells, complete EMT is characterized by a dynamic reorganization of the cytoskeleton with the subsequent generation of a mesenchymal/contractile phenotype (alpha-SMA and vimentin networks) and the loss of the epithelial markers E-cadherin and ZO-1. |
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| 19134459 | Chen TF, Chen M, Qin JH, Wang MY: [Interventional effects of emodin on transforming growth factor-beta1/integrin-linked kinase signal way in interleukin-1beta-induced transdifferentiation of rat tubular epithelial-myofibroblasts]. Zhong Xi Yi Jie He Xue Bao. 2009 Jan;7(1):59-64. The expressions of alpha-smooth muscle actin (alpha-SMA) and E-cadherin were detected by two-color immunohistochemical staining, while the expressions of TGF-beta1 and ILK were detected by one-color immunohistochemical staining. |
2(0,0,0,2) | Details |
| 18538087 | Chen TF, Chen M, Qin JH, Wang MY: [Interventional effect of emodin on the expression of intergern linked kinase in tubular epithelial-myofibroblast transdifferentiation]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Jun;24(6):574-6. The expression of a-smooth muscle actin (a-SMA) and E-cadherin were detected using a two-color immunohistochemistry staining technique, while the expression of integrin-linked kinase (ILK) was detected using a one-color immunohistochemistry staining technique. |
2(0,0,0,2) | Details |
| 19296469 | Van Hul NK, Abarca-Quinones J, Sempoux C, Horsmans Y, Leclercq IA: Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury. Hepatology. 2009 May;49(5):1625-35. The expression of CK19, alpha-fetoprotein, E-cadherin, and CD49f messenger RNA (mRNA), largely overexpressed by LPCs, significantly increased between day 7 and day 10. |
1(0,0,0,1) | Details |
| 20177740 | Deng B, Yang X, Liu J, He F, Zhu Z, Zhang C: Focal adhesion kinase mediates TGF-beta1-induced renal tubular epithelial-to-mesenchymal transition in vitro. Mol Cell Biochem. 2010 Feb 23. TGF-beta1-induced down-regulation of E-cadherin was recovered by a PI3K/Akt inhibitor, LY294002, without affecting the expression of FAK. |
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