Protein Information

Name vimentin
Synonyms VIM; Vimentin; Vimentins

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19661226 Kusner LL, Young A, Tjoe S, Leahy P, Kaminski HJ: Perimysial fibroblasts of extraocular muscle, as unique as the muscle fibers. Invest Ophthalmol Vis Sci. 2010 Jan;51(1):192-200. Epub 2009 Aug 6.


EOM- and LM-Fibro were assessed morphologically and for vimentin, smooth muscle actin, and Thy-1 immunoreactivity.
2(0,0,0,2) Details
17845222 Madekurozwa MC: An immunohistochemical study of the distribution of intermediate filaments in the ovary of the emu (Dromaius novaehollandiae). Anat Histol Embryol. 2007 Oct;36(5):336-42.


The immunohistochemical localization of the intermediate filaments desmin, vimentin and smooth muscle actin (SMA) in the ovary of the emu was described in the present study.
2(0,0,0,2) Details
18344448 Kaempf S, Johnen S, Salz AK, Weinberger A, Walter P, Thumann G: Effects of bevacizumab (Avastin) on retinal cells in organotypic culture. Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3164-71. Epub 2008 Mar 14.


After 3 days in culture, the neural retinas alone and the retina-RPE-choroid complexes were analyzed histologically and immunohistochemically for the expression of glial fibrillary acidic protein (GFAP), vimentin, glutamine synthetase, rhodopsin, smooth muscle actin (SMA), and apoptosis.
2(0,0,0,2) Details
18369529 Makuria AT, Rushing EJ, McGrail KM, Hartmann DP, Azumi N, Ozdemirli M: Atypical teratoid rhabdoid tumor (AT/RT) in adults: review of four cases. J Neurooncol. 2008 Jul;88(3):321-30. Epub 2008 Mar 28.


Immunohistochemical staining showed that the tumor cells were positive for vimentin and reacted variably for keratin, epithelial membrane antigen (EMA), synaptophysin, neurofilament protein, CD34, and smooth muscle actin (SMA).
1(0,0,0,1) Details
18503097 Van Beneden K, van Grunsven LA, Geers C, Pauwels M, Desmouliere A, Verbeelen D, Geerts A, Van den Branden C: CRBP-I in the renal tubulointerstitial compartment of healthy rats and rats with renal fibrosis. Nephrol Dial Transplant. 2008 Nov;23(11):3464-71. Epub 2008 May 25.


Western blotting was performed to semi-quantify the expression levels of vimentin, desmin, alpha-SMA and CRBP-I.
1(0,0,0,1) Details
19323940 Zhao HF, Chen J, Xu ZS, Zhang KQ: Distribution and differentiation of mesenchymal stem cells in tumor tissue. Chin Med J. 2009 Mar 20;122(6):712-5.


The double labeling immunofluorescence for alpha-smooth muscle actin (alpha-SMA) and vimentin was performed to identify whether the MSCs can differentiate into myofibroblast.
2(0,0,0,2) Details
19375841 Yoo YA, Kang MH, Kim BS, Kim JS, Seo JH: Sustained co-cultivation with human placenta-derived MSCs enhances ALK5/Smad3 signaling in human breast epithelial cells, leading to EMT and differentiation. Differentiation. 2009 Jun;77(5):450-61. Epub 2009 Apr 17.


We show that after co-culture with hPMSCs, human mammary epithelial cell lines (MCF-10F and HEMC) underwent significant morphologic alterations and a dramatic increase in ductal-alveolar branching, which was accompanied by a decrease or loss of the epithelial marker E-cadherin and a gain of the mesenchymal markers, alpha-SMA and vimentin.
1(0,0,0,1) Details
19863672 Orzechowska BU, Manoharan M, Sprague J, Estep RD, Axthelm MK, Wong SW: Viral interleukin-6 encoded by rhesus macaque rhadinovirus is associated with lymphoproliferative disorder (LPD). J Med Primatol. 2009 Oct;38 Suppl 1:2-7.


Similarly to KS, RF lesion is positive for vimentin, CD117 (c-kit), and smooth muscle actin (SMA) and contains T cell, B cell and monocytes/macrophage infiltrates.
1(0,0,0,1) Details
18720751 Colovic R, Grubor N, Misev M, Jovanovic M, Radak V: [Fibromyxoid sarcoma of the pancreas] . Srp Arh Celok Lek. 2008 Mar-Apr;136(3-4):158-61.


Immunohistochemistry showed diffuse vimentin and CD34 strong positivity, as well as focal anti-SMA and anti-EMA immunopositivity.
1(0,0,0,1) Details
18036812 Yamate J, Ogata K, Yuasa T, Kuwamura M, Takenaka S, Kumagai D, Itoh K, LaMarre J: Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells. Eur J Cancer. 2007 Dec;43(18):2747-56.


Immunocytochemically, MT-9 cells and MT-9-induced tumours reacted to vimentin, A3 (rat MFH cell-specific antibody), macrophage markers and alpha-SMA (myofibroblastic marker), indicating that MT-9 showed both histiocytic and (myo) fibroblastic features.
1(0,0,0,1) Details
19747592 Chaurasia SS, Kaur H, de Medeiros FW, Smith SD, Wilson SE: Reprint of "Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injury". Exp Eye Res. 2009 Oct;89(4):590-6.

6(0,0,0,6) Details
19285070 Chaurasia SS, Kaur H, de Medeiros FW, Smith SD, Wilson SE: Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injury. Exp Eye Res. 2009 Aug;89(2):133-9. Epub 2009 Mar 11.

6(0,0,0,6) Details
20134119 Devkota B, Sasaki M, Matsui M, Takahashi KI, Matsuzaki S, Koseki T, Miyake YI: Effects of Scrotal Insulation and Pathological Lesions on alpha-Smooth Muscle Actin (SMA) and Vimentin in the Bull Testes. J Reprod Dev. 2010 Feb 5.

5(0,0,0,5) Details
19080126 Liu DG, Wang TM: Role of connective tissue growth factor in experimental radiation nephropathy in rats. Chin Med J. 2008 Oct 5;121(19):1925-31.


The expression of alpha-smooth muscle actin, vimentin, type III collagen and type IV collagen was also high in the irradiated kidney as compared to control rat kidneys (P < 0.05), and was most severe at the sixth and ninth month after irradiation (P < 0.01).
4(0,0,0,4) Details
19577381 Fraternali Orcioni G, Louis Ravetti J, Gaggero G, Bocca B, Bisceglia M: Primary embryonal spindle cell cardiac rhabdomyosarcoma: Case report. Pathol Res Pract. 2009 Jul 2.


At immunohistochemistry, the tumor cells stained strongly and diffusely with vimentin, muscle-specific actin, desmin and myogenin, and focally with fast-myosin and sarcomeric actin.
1(0,0,0,1) Details
19216214 Samaras V, Stamatelli A, Samaras E, Stergiou I, Konstantopoulou P, Varsos V, Judkins AR, Biegel JA, Barbatis C: Atypical teratoid/rhabdoid tumor of the central nervous system in an 18-year-old patient. Clin Neuropathol. 2009 Jan-Feb;28(1):1-10.


RESULTS: Histological and immunohistochemical analysis demonstrated atypical rhabdoid cells strongly and diffusely positive for EMA and Vimentin as well as focally immunoreactive for SMA and GFAP.
1(0,0,0,1) Details
18282168 Suri V, Shukla B, Garg A, Singh M, Rishi A, Sharma MC, Sarkar C: Intracranial inflammatory pseudotumor: report of a rare case. Neuropathology. 2008 Aug;28(4):444-7. Epub 2008 Feb 16.


The spindled cells were diffusely immunopositive for vimentin and only occasional cells were positive for smooth muscle actin (SMA).
1(0,0,0,1) Details
20052656 Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA: Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology. 2010 Mar;51(3):1027-36.


All beta-gal-positive cells exhibited abundant cytoplasm, a typical morphology of hepatocytes, and expressed none of the mesenchymal markers including alpha-SMA, FSP-1, desmin, and vimentin.
1(0,0,0,1) Details
18359707 Liu J, Liu YH: [Expression of CD117, CD34, SMA, S-100 protein, Vim and desmin in patients with gastrointestinal stromal tumors]. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Mar;28(3):438-40.


OBJECTIVE: To investigate the clinicopathological diagnosis and expressions of CD117, CD34, SMA, S-100 protein, Vimentin (Vim) and desmin in gastrointestinal stromal tumors (GISTs).
1(0,0,0,1) Details
19190330 Khawam K, Giron-Michel J, Gu Y, Perier A, Giuliani M, Caignard A, Devocelle A, Ferrini S, Fabbi M, Charpentier B, Ludwig A, Chouaib S, Azzarone B, Eid P: Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition. Cancer Res. 2009 Feb 15;69(4):1561-9. Epub 2009 Feb 3.


In these cells, complete EMT is characterized by a dynamic reorganization of the cytoskeleton with the subsequent generation of a mesenchymal/contractile phenotype (alpha-SMA and vimentin networks) and the loss of the epithelial markers E-cadherin and ZO-1.
1(0,0,0,1) Details
18155753 Bob FR, Gluhovschi G, Herman D, Potencz E, Gluhovschi C, Trandafirescu V, Schiller A, Petrica L, Velciov S, Bozdog G, Vernic C: Histological, immunohistochemical and biological data in assessing interstitial fibrosis in patients with chronic glomerulonephritis. Acta Histochem. 2008;110(3):196-203. Epub 2007 Dec 26.


IHC labeling procedures with monoclonal antibodies anti-smooth muscle actin (SMA), anti-vimentin and anti-transforming growth factor beta (TGFbeta) were assessed using a semi-quantitative score, correlated with the histological and biological data.
4(0,0,0,4) Details
17701211 Aresu L, Rastaldi MP, Scanziani E, Baily J, Radaelli E, Pregel P, Valenza F: Epithelial-mesenchymal transition (EMT) of renal tubular cells in canine glomerulonephritis. Virchows Arch. 2007 Nov;451(5):937-42. Epub 2007 Aug 15.


Immunohistochemistry showed the expression of the epithelial marker cytokeratin, the smooth muscle marker alpha-SMA, the mesenchymal marker vimentin and PCNA in 20 dogs with membranous glomerulonephritis and membrano-proliferative glomerulonephritis.
3(0,0,0,3) Details
19391488 Rys J, Karolewski K, Pudelek J, Kruczak A, Wasilewska A, Vogelgesang M, Kojs Z: Perivascular epithelioid tumor (PEComa) of the falciform/ broad ligament. . Pol J Pathol. 2008;59(4):211-5.


Histologically, the tumor was composed of nests of epithelioid clear cells stained positively for vimentin, HMB45, and SMA.
1(0,0,0,1) Details
17883129 Majhi U, Shirley S, Murhekar K: Follicular dendritic cell sarcoma of oral cavity: report of 2 cases. Indian J Pathol Microbiol. 2007 Jul;50(3):545-7.


One of them was of low grade malignancy and showed positivity for of Vimentin.
1(0,0,0,1) Details
19323373 Qi XP, Lin GB, Zhu YL, Wang JQ, Dai XW, Ma JM, Yan L: [Pseudoangiosarcomatous squamous cell carcinoma of the penis: a case report with clinicopathological and human papilloma virus analyses]. Zhonghua Nan Ke Xue. 2009 Feb;15(2):134-9.


Immunohistochemically, most tumor cells were strongly positive for keratin (AE1/AE3) and focally positive for EMA, with the typical squamous cells focally positive for 34betaE12 and vimentin.
1(0,0,0,1) Details
20068185 Wang J, Ying G, Wang J, Jung Y, Lu J, Zhu J, Pienta KJ, Taichman RS: Characterization of phosphoglycerate kinase-1 expression of stromal cells derived from tumor microenvironment in prostate cancer progression. Cancer Res. 2010 Jan 15;70(2):471-80. Epub 2010 Jan 12.


Normal fibroblasts overexpressing PGK1 resembled myofibroblasts in their expression of smooth muscle alpha-actin, vimentin, and high levels of CXCL12.
1(0,0,0,1) Details
19937078 Mouravas VK, Koletsa T, Sfougaris DK, Philippopoulos A, Petropoulos AS, Zavitsanakis A, Kostopoulos I: Smooth muscle cell differentiation in the processus vaginalis of children with hernia or hydrocele. Hernia. 2009 Nov 24.


The aim of this study was to evaluate the diversity and differentiation of smooth muscle phenotypes in sacs associated with inguinal hernia and hydrocele through the expression of alpha-smooth muscle actin (SMA), h-caldesmon, desmin, and vimentin.
3(0,0,0,3) Details
19056781 Dudas PL, Argentieri RL, Farrell FX: BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells. Nephrol Dial Transplant. 2009 May;24(5):1406-16. Epub 2008 Dec 4.


METHODS: EMT was determined by quantitative real-time PCR analysis of e-cadherin, vimentin, CTGF and TGF-beta1 transcript expression and immunocytochemical analysis of ZO-1 and alpha-smooth muscle actin (alpha-SMA) protein expression following TGF-beta1 treatment in RPTEC and HK-2 cells.
3(0,0,0,3) Details
17695417 Angiero F, Rizzuti T, Crippa R, Stefani M: Fibrosarcoma of the jaws: two cases of primary tumors with intraosseous growth. Anticancer Res. 2007 Jul-Aug;27(4C):2573-81.


We discuss the differential diagnosis versus other forms of sarcoma, examining the morphological appearance that is frequently very similar, the immunohistochemical expression of MIB-1, vimentin, S-100, CD-34, CD68, EMA, as well as conventional clinicopathological features that may help to distinguish FS from other sarcomas.
1(0,0,0,1) Details
19900406 Du R, Huang C, Bi Q, Zhai Y, Xia L, Liu J, Sun S, Fan D: URG11 mediates hypoxia-induced epithelial-to-mesenchymal transition by modulation of E-cadherin and beta-catenin. Biochem Biophys Res Commun. 2010 Jan 1;391(1):135-41. Epub 2009 Nov 11.


Overexpression of URG11 in a human proximal tubule cell line (HK2) promoted a mesenchymal phenotype accompanied by reduced expression of the epithelial marker E-cadherin and increased expression of the mesenchymal markers vimentin and alpha-SMA, while URG11 knockdown by siRNA effectively reversed hypoxia-induced EMT.
1(0,0,0,1) Details
19659836 Kuroishi S, Suda T, Fujisawa T, Ide K, Inui N, Nakamura Y, Nakamura H, Chida K: Epithelial-mesenchymal transition induced by transforming growth factor-beta1 in mouse tracheal epithelial cells. Respirology. 2009 Aug;14(6):828-37. Epub 2009 Jul 29.


RESULTS: Immunofluorescence staining and western blotting revealed that TGF-beta1 treatment for 14 days induced the expression of the mesenchymal markers, alpha-smooth muscle actin (alpha-SMA) and vimentin, and reduced the expression of the epithelial markers, zonula occludens-1 (Zo-1) and occludin.
1(0,0,0,1) Details
18446631 Pauli J, Gundelach R, Vanelli-Rees A, Rees G, Campbell C, Dubey S, Perry C: Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell. Pathology. 2008 Jun;40(4):396-400.


Our objective is to evaluate the immunohistochemical phenotype of the stromal cell of JNA, particularly within the proliferative zone of the tumour, by application of antibodies against MNF116, CAM5.2, S-100, CD31, CD34, CD99, CD68, vimentin, EMA, SMA, desmin, calponin, Bcl-2 and (CD117) c-kit in a series of 54 cases.
1(0,0,0,1) Details
19640259 Li J, Zhang Z, Wang D, Wang Y, Li Y, Wu G: TGF-beta 1/Smads signaling stimulates renal interstitial fibrosis in experimental AAN. J Recept Signal Transduct Res. 2009;29(5):280-5.


Immunohistochemistry and semi-quantitative reverse transcriptase (RT-PCR) detection of the increased expression of fibroblast marker vimentin and de novo expression of alpha-smooth muscle actin (alpha-SMA) with the loss of epithelial maker cytokeratin 18 (CK18) can be utilized to assess AAI-induced tubular necrosis and extensive cortical interstitial fibrosis in a dose-dependent manner.
1(0,0,0,1) Details
19483715 Zhou Y, Xiao XQ, Chen LF, Yang R, Shi JD, Du XL, Klocker H, Park I, Lee C, Zhang J: Proliferation and phenotypic changes of stromal cells in response to varying estrogen/androgen levels in castrated rats. Asian J Androl. 2009 Jul;11(4):451-9. Epub 2009 Jun 1.


In this group, cells positive for Vimentin, non-muscle myosin heavy chain (NMMHC) and proliferating cell nuclear antigen (PCNA) increased in the stroma and epithelium.
1(0,0,0,1) Details
19781193 Ding Z, Chen ZS, Chen XL, Guo H, Gong NQ: [Inducing of epithelial mesenchymal transition of HK-2 cells by connective tissue growth factor in vitro]. Zhonghua Bing Li Xue Za Zhi. 2009 Jul;38(7):462-5.


Direct immunofluorescence staining and immunohistochemistry were used to evaluate the E-cadherin, Vimentin, alpha-SMA and ERK2 in cells.
3(0,0,0,3) Details
19259356 Chea SW, Lee KB: TGF-beta mediated epithelial-mesenchymal transition in autosomal dominant polycystic kidney disease. Yonsei Med J. 2009 Feb 28;50(1):105-11. Epub 2009 Feb 24.


We evaluated alpha-SMA, E-cadherin, vimentin, TGF-beta1 and Smad 2/3 expression in ADPKD and compared them with those in control kidney.
3(0,0,0,3) Details
19145686 Zissis D, Zizi-Serbetzoglou A, Glava C, Grammatoglou X, Katsamagkou E, Nikolaidou ME, Vasilakaki T: Glomus tumor of the stomach: a case report. J BUON. 2008 Oct-Dec;13(4):581-4.


Biopsies taken from the lesion showed morphological and immunohistochemical [positivity for alphasmooth muscle actin (alpha-SMA) and vimentin, negativity for CD34, CD117, chromogranin, synaptophysin, desmin and S-100 protein] characteristics attributable to glomus tumor.
1(0,0,0,1) Details
19323797 van Engelen E, Breeveld-Dwarkasing VN, Everts ME, van der Weyden GC, Taverne MA, Rutten VP: Smooth muscle cells of the bovine cervical stroma may have a secretory, rather than a contractile function during parturition. Reprod Domest Anim. 2009 Apr;44(2):303-11.


The smooth muscle bundles of the stroma were immunohistochemically analysed (n = 5) with regard to their integrity and cellular density, and the degree of staining for connexin-43, smooth muscle actin alpha (SMA), desmin and vimentin.
3(0,0,0,3) Details
18662738 Wojcikowski K, Wohlmuth H, Johnson DW, Gobe G: Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways. Food Chem Toxicol. 2008 Sep;46(9):3122-31. Epub 2008 Jul 10.


Macrophage infiltration (ED-1), epithelial-to-mesenchymal transdifferentiation or activation of fibroblasts (vimentin, alpha-SMA), and pro-fibrotic growth factors (TGFss1, CTGF) were assessed using IHC.
3(0,0,0,3) Details
18802012 Hao Q, Liu J, Pappu R, Su H, Rola R, Gabriel RA, Lee CZ, Young WL, Yang GY: Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages. Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2151-7. Epub 2008 Sep 18.


The GFP-positive BMDCs were colocalized with CD45 (94%), CD68 (71%), 5% Vimentin (5%), CD31/von Willebrand factor (vWF) (1%), and alpha-smooth muscle actin (alpha -SMA, 0.5%).
1(0,0,0,1) Details
17724219 Lee H, O'Meara SJ, O'Brien C, Kane R: The role of gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4291-9.


The expression of alpha-smooth muscle actin (alpha-SMA), vimentin, and zona occludens (ZO)-1 were examined via PCR, Western blot analysis, and immunofluorescence.
1(0,0,0,1) Details
20007519 McNearney TA, Ma Y, Chen Y, Taglialatela G, Yin H, Zhang WR, Westlund KN: A peripheral neuroimmune link: glutamate agonists upregulate NMDA NR1 receptor mRNA and protein, vimentin, TNF-alpha, and RANTES in cultured human synoviocytes. Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R584-98. Epub 2009 Dec 9.

3(0,0,0,3) Details
19696546 Maeng LS, Chang ED, Chae HS, Kim JS, Min JY, Sohn HS, Rho SY, Kim HK, Cho YS, Choi KY, Lee HK: [Therapeutic effect of allogenic bone marrow transplantation in acute TNBS-induced colitis]. Korean J Gastroenterol. 2009 Jul;54(1):20-7.


The immunostaining of vimentin and alpha-smooth muscle actin (alpha-SMA) for myofibroblasts was performed.
3(0,0,0,3) Details
17601762 Firat I, Haktanir-Yatkin D, Sontas BH, Ekici H: Vulvar leiomyosarcoma in a cat. J Feline Med Surg. 2007 Oct;9(5):435-8. Epub 2007 Jun 29.


The vascular elements of the internal control tissue also exhibited strong SMA and vimentin immunoreactivity.
1(0,0,0,1) Details
18317806 Maeda T, Hashitani S, Zushi Y, Segawa E, Tanaka N, Sakurai K, Urade M: Establishment of a nude mouse transplantable model of a human malignant fibrous histiocytoma of the mandible with high metastatic potential to the lung. J Cancer Res Clin Oncol. 2008 Sep;134(9):1005-11. Epub 2008 Mar 4.


Immunohistochemically, both the original and xenografted tumors expressed vimentin, S-100, alpha-SMA, and histiocytic marker CD68.
1(0,0,0,1) Details
18702012 Wang Y, Zhang Z, Shen H, Lu Y, Li H, Ren X, Wu G: TGF-beta1/Smad7 signaling stimulates renal tubulointerstitial fibrosis induced by AAI. J Recept Signal Transduct Res. 2008;28(4):413-28.


This was also immediately identified by the increased expression of vimentin and de novo expression of alpha-smooth muscle actin (alpha-SMA) with the loss of cytokeratin 18 (CK18) by semiquantitative reverse transcriptase-PCR (RT-PCR) and immunofluorescence staining.
1(0,0,0,1) Details
18688640 Gluhovschi C, Gluhovschi G, Potencz E, Herman D, Petrica L, Velciov S, Bozdog G, Bob F, Vernic C, Cioca D: What is the significance of CD34 immunostaining in the extraglomerular and intraglomerular mesangium?. Virchows Arch. 2008 Oct;453(4):321-8. Epub 2008 Aug 8.


Conventional stains: hematoxylin-eosin, periodic acid Schiff, and Trichrome Gomori, as well as immunohistochemistry: CD34, alpha smooth muscle actin (alpha SMA), vimentin, and proliferating cell nuclear antigen (PCNA) were employed.
2(0,0,0,2) Details
19952797 Liu ZJ, Zhang LJ, Zhao Q, Li QW, Wang EB, Ji SJ, Shu H: Pediatric synovial sarcoma of the sacrum: a case report. J Pediatr Orthop B. 2010 Mar;19(2):207-10.


CK, CK7, CK1, CK3, CK8, CK19, Bcl-2, E-cadherin, ki-67, P53, SMA, CD99, CD56, S-100, vimentin, and epithelial membrane antigen were positive.
2(0,0,0,2) Details
19175711 Ramirez-Amador V, Martinez-Mata G, Gonzalez-Ramirez I, Anaya-Saavedra G, de Almeida OP: Clinical, histological and immunohistochemical findings in oral Kaposi's sarcoma in a series of Mexican AIDS patients. J Oral Pathol Med. 2009 Apr;38(4):328-33. Epub 2009 Jan 23.


Immunohistochemical studies were performed for vimentin, alpha SMA, desmin, C-kit, CD34, D2-40 and LANA-1 [human herpesvirus-8 (HHV-8)].
2(0,0,0,2) Details
19059821 Chummun S, McLean NR, Abraham S, Youseff M: Desmoid tumour of the breast. . J Plast Reconstr Aesthet Surg. 2010 Feb;63(2):339-45. Epub 2008 Dec 6.


Immunochemistry showed strong positivity for vimentin and variable positivity for SMA and desmin, and patchy positivity for beta catenin.
1(0,0,0,1) Details
19198871 Franz M, Spiegel K, Umbreit C, Richter P, Codina-Canet C, Berndt A, Altendorf-Hofmann A, Koscielny S, Hyckel P, Kosmehl H, Virtanen I, Berndt A: Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma. Histochem Cell Biol. 2009 May;131(5):651-60. Epub 2009 Feb 6.


Additionally, the influence of TGF beta 1 and EGF on Snail, E-cadherin, vimentin, and alpha SMA expression was analysed in two OSCC cell lines.
1(0,0,0,1) Details
18518656 Han RI, Black A, Culshaw GJ, French AT, Else RW, Corcoran BM: Distribution of myofibroblasts, smooth muscle-like cells, macrophages, and mast cells in mitral valve leaflets of dogs with myxomatous mitral valve disease. Am J Vet Res. 2008 Jun;69(6):763-9.


PROCEDURES: A combination of standard histologic and immunohistochemical techniques was used to identify pathologic changes, the presence of mast cells, and the density and distribution of cells expressing vimentin, desmin, alpha-smooth muscle actin (alpha-SMA), smooth muscle myosin, and the macrophage marker MAC387.
3(0,0,0,3) Details
17577399 Martorell M, Perez-Valles A, Gozalbo F, Garcia-Garcia JA, Gutierrez J, Gaona J: Solitary fibrous tumor of the thigh with epithelioid features: a case report. Diagn Pathol. 2007 Jun 18;2:19.


Immunohistochemically, they commonly express CD34, vimentin, bcl-2 and CD99.
2(0,0,0,2) Details
17923018 Xu GP, Li QQ, Cao XX, Chen Q, Zhao ZH, Diao ZQ, Xu ZD: [Effect of Smad7 on transforming growth factor-beta1-induced alveolar epithelial to mesenchymal transition]. Zhonghua Yi Xue Za Zhi. 2007 Jul 17;87(27):1918-23.


The expression of the markers of the epithelial cells, including E-cadherin and cytokeratin-19 (CK19), and markers of mesenchymal cells, including fibronectin (FN), vimentin, and alpha-smooth muscle actin (alpha-SMA) were assayed using Western blotting and real-time PCR.
1(0,0,0,1) Details
19451194 Mehasseb MK, Bell SC, Habiba MA: The effects of tamoxifen and estradiol on myometrial differentiation and organization during early uterine development in the CD1 mouse. Reproduction. 2009 Aug;138(2):341-50. Epub 2009 May 18.


We examined the sections histologically, using image analysis and immunohistochemistry for alpha-smooth muscle actin (alpha-SMA), desmin, vimentin, laminin, fibronectin, and estrogen receptor-alpha.
1(0,0,0,1) Details
19052772 Van Rossen E, Vander Borght S, van Grunsven LA, Reynaert H, Bruggeman V, Blomhoff R, Roskams T, Geerts A: Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver. Histochem Cell Biol. 2009 Mar;131(3):313-25. Epub 2008 Dec 4.


With immunohistochemistry we examined the expression of synemin, desmin, vimentin, vinculin, neurotrophin-3 (NT-3), alpha-smooth muscle actin (alpha-SMA), cellular retinol-binding protein-1 (CRBP-1), glial fibrillary acidic protein (GFAP), cysteine- and glycine-rich protein 2 (CRP2), and cytoglobin/stellate cell activation-associated protein (cygb/STAP).
1(0,0,0,1) Details
19319643 Dell'Avanzato R, Carboni F, Palmieri MB, Palmirotta R, Guadagni F, Pippa G, Santeusanio G, Antimi M, Lopez M, Carlini M: Laparoscopic resection of sporadic synchronous gastric and jejunal gastrointestinal stromal tumors: report of a case. Surg Today. 2009;39(4):335-9. Epub 2009 Mar 25.


Immunohistochemical analysis revealed that both lesions were KIT (CD117)-positive, but that the gastric lesion was CD34-positive, whereas the jejunal one was Vimentin-, S-100-, and SMA-positive.
1(0,0,0,1) Details
20223349 Defaud-Henon F, Tunon-de-Lara C, Fournier M, Marty M, Velasco V, de Mascarel I, MacGrogan G: [Adenoid cystic carcinoma of the breast: clinical, histological and immunohistochemical characterization]. Ann Pathol. 2010 Feb;30(1):7-16. Epub 2010 Feb 18.


An immunohistochemical study was performed with the following antibodies: ER, PR, HER-2-neu, Vimentin, EGFR, P63, SMA, CK5/6, CK8/18, CK14, cKIT, MIB1, CD44 and CD24.
1(0,0,0,1) Details
19271685 Mokry J, Ehrmann J, Karbanova J, Cizkova D, Soukup T, Suchanek J, Filip S, Kolar Z: Expression of intermediate filament nestin in blood vessels of neural and non-neural tissues. Acta Medica (Hradec Kralove). 2008;51(3):173-9.


To reach this goal we performed double immunofluorescent study to co-localize nestin with endothelium-specific markers (CD31, CD34 II, vimentin) or markers of perivascular cells (GFAP, SMA) in paraffin-embedded sections of normal human brain tissue, low- and high-grade gliomas, postinfarcted heart and samples of non-neural tumours.
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17761239 Stathas D, Kalfakis N, Kararizou E, Manta P: Spinal muscular atrophy: DNA fragmentation and immaturity of muscle fibers. Acta Histochem. 2008;110(1):53-8. Epub 2007 Aug 29.


The presence of apoptotic fibers and the embryonic proteins desmin and vimentin were investigated in muscle biopsy specimens from patients with spinal muscular atrophy (SMA).
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18154518 Kim J, Kang HM, Kim H, Kim MR, Kwon HC, Gye MC, Kang SG, Yang HS, You J: Ex vivo characteristics of human amniotic membrane-derived stem cells. . Cloning Stem Cells. 2007 Winter;9(4):581-94.


Immunophenotype analysis of HAM cells revealed the presence of antigens for SSEA-3, SSEA-4, collagen type-I, -II, -III, -IV, -XII, fibronectin, alpha-SMA, vimentin, desmin, cytokeratin18 (CK18), HCAM-1, fibroblast surface protein, and human leukocyte antigen (HLA) ABC.
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19281784 Orlandi A, Hao H, Ferlosio A, Clement S, Hirota S, Spagnoli LG, Gabbiani G, Chaponnier C: Alpha actin isoforms expression in human and rat adult cardiac conduction system. Differentiation. 2009 Apr;77(4):360-8. Epub 2009 Feb 4.


SAN and IB cardiomyocytes were characterized by the presence of alpha-SMA, alpha-CA, calponin and caldesmon, whereas alpha-SKA and vimentin were absent.
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19377054 Roy-Chaudhury P, Wang Y, Krishnamoorthy M, Zhang J, Banerjee R, Munda R, Heffelfinger S, Arend L: Cellular phenotypes in human stenotic lesions from haemodialysis vascular access. Nephrol Dial Transplant. 2009 Sep;24(9):2786-91. Epub 2009 Apr 17.


METHODS: Discarded tissue segments were collected from the stenotic portions (usually near the graft-vein anastomosis or the AV anastomosis) of 23 dialysis grafts and 20 AV fistulae, and examined for expression of smooth muscle alpha actin, desmin, vimentin and a macrophage marker.
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19648289 Felton VM, Borok Z, Willis BC: N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition. Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L805-12. Epub 2009 Jul 31.


RLE-6TN cells exposed to TGF-beta1 for 5 days underwent EMT as evidenced by acquisition of a fibroblast-like morphology, downregulation of the epithelial-specific protein zonula occludens-1, and induction of the mesenchymal-specific proteins alpha-smooth muscle actin (alpha-SMA) and vimentin.
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20038894 Brasileiro BF, Martins-Filho PR, Piva MR, Silva LC, Nonaka CF, Miguel MC: Myofibroma of the oral cavity. Med Oral Patol Oral Cir Bucal. 2009 Dec 29.


An immunohistochemical panel consisting of antibodies to vimentin, SMA, HHF-35, S-100p and desmin must be achieved.
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17963954 Martinez EF, Araujo VC, Sousa SO, Arana-Chavez VE: TGF-beta1 enhances the expression of alpha-smooth muscle actin in cultured human pulpal fibroblasts: immunochemical and ultrastructural analyses. J Endod. 2007 Nov;33(11):1313-8. Epub 2007 Sep 17.


In addition, the expression of tenascin, osteonectin, and vimentin was also investigated.
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17708776 Efstathios P, Athanasios P, Papaconstantinou I, Alexandros P, Frangisca S, Sotirios G, Evangelos F, Athanasios G: Coexistence of gastrointestinal stromal tumor (GIST) and colorectal adenocarcinoma: A case report. World J Surg Oncol. 2007 Aug 21;5:96.


Immunohistochemical examination revealed the concurrence of histologically proved GIST (strongly positive staining for c-kit, vimentin, SMA, and focal positive in S-100, while CD-34 was negative) and Dukes Stage C, (T3, N3, M0 according the TNM staging classification of colorectal cancer).
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18596079 Vidyasagar A, Reese S, Acun Z, Hullett D, Djamali A: HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis. Am J Physiol Renal Physiol. 2008 Sep;295(3):F707-16. Epub 2008 Jul 2.


Real-time PCR analyses showed that HSP27, vimentin, and fibronectin increased whereas E-cadherin mRNA levels decreased.
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19461215 Do SH, Hong IH, Park JK, Ji AR, Kim TH, Kwak DM, Jeong KS: Two different types of malignant fibrous histiocytomas from pet dogs. J Vet Sci. 2009 Jun;10(2):169-71.


To classify these tumors, we applied a panel of antibodies (vimentin, desmin, alpha-SMA, and ED1) and Azan staining for collagen.
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19801454 Zhou G, Dada LA, Wu M, Kelly A, Trejo H, Zhou Q, Varga J, Sznajder JI: Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1. Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1120-30. Epub 2009 Oct 2.


We found that hypoxia induced the expression of alpha-smooth muscle actin (alpha-SMA) and vimentin and decreased the expression of E-cadherin in transformed and primary human, rat, and mouse AEC, suggesting that hypoxia induces EMT in AEC.
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18197550 Nishioka Y, Miyazaki M, Abe K, Furusu A, Harada T, Ozono Y, Taguchi T, Koji T, Kohno S: Regeneration of peritoneal mesothelium in a rat model of peritoneal fibrosis. Ren Fail. 2008;30(1):97-105.


Immunohistochemistry identified staining for vimentin, a marker of mesoderm cells, in the spindle-shaped cells at days 3, 5, and 7.
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18261305 Luo DL, Liu YH, Zhuang HG, Luo XL: [Tumors showing perivascular epithelioid cell differentiation: a clinicopathologic study of 39 cases]. Zhonghua Yi Xue Za Zhi. 2007 Nov 6;87(41):2909-13.


Immunohistochemistry (HIC) was used to detect the expression of pan-cytokeratin (CK), S-100 protein, smooth muscle actin (SMA), desmin, vimentin, HMB45, Melan-A, microphthalmia transcription factor (MiTF), CD117, and CD34 in the specimens of the tumors obtained during operation.
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18677391 Huang YJ, Huang X, Shi XY, Lu J: [Pathological characteristics mixed epithelial and stromal tumor of kidney]. Beijing Da Xue Xue Bao. 2008 Aug 18;40(4):415-8.


Immunohistochemical staining revealed that the epithelial components were positive for AE1/AE3 and focally positive for estrogen receptor (ER),progesterone receptor (PR), CD10 and Vimentin, whereas the stromal components were positive for ER, PR, Desmin and smooth muscle actin (SMA).
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18841827 Di Blasi A, Ferrara G, Antinolfi G, Dalena AM, Antinolfi F: [Clear cell adenomyoepithelioma of the ceruminous gland] . Pathologica. 2008 Jun;100(3):192-6.


Clear cells were weakly positive for CK18 and strongly positive for vimentin; they also displayed S100 protein and focal GFAP immunoreactivity.
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17571460 Ke Q, Erbolat, Zhang HY, Bu H, Li S, Shi DN, Yang GH, Chen HJ, Wei B: Clinicopathologic features of pleomorphic hyalinizing angiectatic tumor of soft parts. Chin Med J. 2007 May 20;120(10):876-81.


Immunohistochemical stains for vimentin, S-100 protein, CD34, CD31, CD99, VEGF, desmin, CD117, alpha-SMA, and MIB-1 were performed with the Envision system.
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18036304 Chen J, Xu ZS, Zhao HF, Dong DX: [Distribution and differentiation of marrow mesenchymal cells in tumor tissue: experimental with rabbits]. Zhonghua Yi Xue Za Zhi. 2007 Sep 4;87(33):2361-4.


Double labeling immunofluorescence for alpha-smooth muscle actin (alpha-SMA) and vimentin was performed to identify whether MSCs could differentiate into myofibroblasts.
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17600313 Liu T, Warburton RR, Guevara OE, Hill NS, Fanburg BL, Gaestel M, Kayyali US: Lack of MK2 inhibits myofibroblast formation and exacerbates pulmonary fibrosis. Am J Respir Cell Mol Biol. 2007 Nov;37(5):507-17. Epub 2007 Jun 28.


While there were many vimentin-positive cells in the bleomycin-treated MK2-/- mouse lungs, few alpha-SMA-positive cells were observed in these lungs compared with wild-type mouse lungs. siRNA against MK2 reduced alpha-SMA expression in wild-type mouse embryonic fibroblasts (MEF), consistent with its suppression in MK2-/- MEF.
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20051653 Iwanaga K, Murata T, Hori M, Ozaki H: Isolation and characterization of bovine intestinal subepithelial myofibroblasts. J Pharmacol Sci. 2010 Jan;112(1):98-104. Epub 2010 Jan 6.


After 2-week incubation, alpha-SMA+ / vimentin+ / desmin (-) ISMFs were harvested and applied for experiments.
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19822338 Yabuki A, Mitani S, Fujiki M, Misumi K, Endo Y, Miyoshi N, Yamato O: Comparative study of chronic kidney disease in dogs and cats: induction of myofibroblasts. Res Vet Sci. 2010 Apr;88(2):294-9. Epub 2009 Oct 12.


Immunohistochemical expression of myofibroblast markers, alpha-smooth muscle actin (SMA) and vimentin, were evaluated quantitatively.
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19035117 Li X, Liu HG, Xie XJ, Han YD, Li M: [Clinicopathologic study of sinonasal teratocarcinosarcoma and its contrast with olfactory neuroblastoma]. Zhonghua Bing Li Xue Za Zhi. 2008 Jul;37(7):458-64.


The spindle cells expressed vimentin, SMA, desmin, myosin and myoglobin.
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20047646 Reese S, Vidyasagar A, Jacobson L, Acun Z, Esnault S, Hullett D, Malter JS, Djamali A: The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model. Fibrogenesis Tissue Repair. 2010 Jan 4;3:1.


RESULTS: After 2 weeks of UUO, immunoblot analyses demonstrated that juglone (0.25 and 1 mg/kg/24 h) inhibited the deposition of matrix (alpha-smooth muscle actin (SMA), collagen type III and vimentin) and the activation of signaling pathways involved in fibrogenesis (phospho-smad2) and stress response (phospho-heat shock protein (HSP) 27).
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20070153 Eyden B: Pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation: a single case report. Ultrastruct Pathol. 2010 Feb;34(1):42-7.


The tumor was positive for vimentin, desmin, alpha-smooth-muscle actin, alpha-sarcomeric actin, myogenin, MyoD1, and CD68.
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18280092 Cau J, Favreau F, Tillement JP, Lerman LO, Hauet T, Goujon JM: Trimetazidine reduces early and long-term effects of experimental renal warm ischemia: a dose effect study. J Vasc Surg. 2008 Apr;47(4):852-860. Epub 2008 Feb 14.


Direct effect of TMZ was determined using different variables: renal function (creatinine clearance; C (cr)) and indirectly, the consequences on inflammation (cells infiltration), rate of apoptosis, fibrosis development, and renal epithelial cells change into myofibroblast, which defined epithelial to mesenchymal transition (alpha-smooth muscle actin [alpha-SMA] and vimentin expression).
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18692477 Iriyama A, Iriyama T, Tamaki Y, Yanagi Y: Effects of white light on beta-catenin signaling pathway in retinal pigment epithelium. Biochem Biophys Res Commun. 2008 Oct 10;375(1):173-7. Epub 2008 Aug 8.


Real time RT-PCR demonstrated that the mRNA of alpha-smooth muscle actin (alpha-SMA), and vimentin increased 2.5-4-fold and that of zona occludens 1 (ZO-1) decreased approximately 0.8-fold after white light exposure.
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17628937 Hirai T, Ikeda D, Sakai A: [A case report: retroperitoneal inflammatory fibrosarcoma that revealed progressive enlargement]. Hinyokika Kiyo. 2007 Jun;53(6):393-6.


Immunostaining examination showed positive staining for alpha-smooth muscle actin (SMA), vimentin, cytokeatins, and CD 68, whereas desmin, CD 34, and p53 were negative.
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19411308 Nasreen N, Mohammed KA, Mubarak KK, Baz MA, Akindipe OA, Fernandez-Bussy S, Antony VB: Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-beta1 in vitro. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L115-24. Epub 2009 May 1.


Cytokeratin-8 and E-cadherin expression decreased whereas vimentin remained unchanged over time in transforming PMC.
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19670705 Gajda M, Zagolski O, Jasztal A, Lis GJ, Adamek D, Litwin JA: Giant schwannoma of the cheek--a comprehensive histological and immunohistochemical description of a rare tumour. Pol J Pathol. 2009 Mar;60(1):52-6.


It showed positive immunostaining for S-100, PGP 9.5, NSE, collagen IV, laminin, merosin and vimentin.
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20112425 Tang DJ, Dong SS, Ma NF, Xie D, Chen L, Fu L, Lau SH, Li Y, Li Y, Guan XY: Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. Hepatology. 2009 Nov 30.


Further study found that EIF5A2 was able to induce epithelial-mesenchymal transition (EMT), a key event in tumor invasion and metastasis, characterized by down-regulation of epithelial markers (E-cadherin and beta-catenin) and up-regulation of mesenchymal markers (fibronectin, N-cadherin, alpha-SMA, and vimentin).
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