Protein Information

Name epithelial membrane antigen
Synonyms Breast carcinoma associated antigen DF3; CD227; CD227 antigen; Carcinoma associated mucin; DF3 antigen; EMA; Episialin; Epithelial membrane antigen…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
20032423 Angiero F, Sozzi D, Seramondi R, Valente MG: Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features. Anticancer Res. 2009 Nov;29(11):4703-9.


RESULTS: Immunohistochemical analysis showed the tumor cells to be weakly positive for S100, cytokeratin (CK) CK5/6, CK7, CKAE-1/AE-3 and strongly positive for epithelial membrane antigen (EMA) and p63; they were focally positive for calponin and acute lymphoblastic leukemia antigen (CD10).
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18987833 Seno T, Kawaguchi T, Yamahara T, Sakurai Y, Oishi T, Inagaki T, Yamanouchi Y, Asai A, Kawamoto K: An immunohistochemical and electron microscopic study of atypical teratoid/rhabdoid tumor. Brain Tumor Pathol. 2008;25(2):79-83. Epub 2008 Nov 6.


However, immunohistochemical staining showed that these tumor cells react positively for cytokeratin, smooth muscle actin (SMA), and epithelial membrane antigen (EMA) and helped us with the differentiation.
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19952797 Liu ZJ, Zhang LJ, Zhao Q, Li QW, Wang EB, Ji SJ, Shu H: Pediatric synovial sarcoma of the sacrum: a case report. J Pediatr Orthop B. 2010 Mar;19(2):207-10.


CK, CK7, CK1, CK3, CK8, CK19, Bcl-2, E-cadherin, ki-67, P53, SMA, CD99, CD56, S-100, vimentin, and epithelial membrane antigen were positive.
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19150605 Bello IO, Alanen K, Slootweg PJ, Salo T: Alpha-smooth muscle actin within epithelial islands is predictive of ameloblastic carcinoma. Oral Oncol. 2009 Sep;45(9):760-5. Epub 2009 Jan 16.


We examined immunohistochemically Ki-67, epithelial membrane antigen (EMA), alpha-smooth muscle actin (alpha-SMA), calponin, p63 and DNA content using image (ICM) and flow cytometry (FCM) in three ameloblastic carcinomas and up to 18 SAs.
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19577381 Fraternali Orcioni G, Louis Ravetti J, Gaggero G, Bocca B, Bisceglia M: Primary embryonal spindle cell cardiac rhabdomyosarcoma: Case report. Pathol Res Pract. 2009 Jul 2.


Staining for alpha-SMA, H-caldesmon, CD34, epithelial membrane antigen (EMA), keratin wide-spectrum (CK w.s.), and S100 protein was negative.
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18460022 Sun B, Sun Y, Wang J, Zhao X, Zhang S, Liu Y, Li X, Feng Y, Zhou H, Hao X: The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases. Cancer Sci. 2008 Jul;99(7):1355-61. Epub 2008 May 2.


The positive ratio of cytokeratin (CK) and epithelial membrane antigen (EMA) in finally diagnosed SS was 51.9% (55/106) and 61.3% (65/106), respectively.
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19615014 Kluger N, Dumas-Tesici A, Hamel D, Brousse N, Fraitag S: Fibroblastic rheumatism: fibromatosis rather than non-Langerhans cell histiocytosis. J Cutan Pathol. 2009 Jul 13.


Histopathology and immunochemistry studies were performed on skin biospies using CD68, CD163, desmin, factor XIIIa, CD34, smooth muscle actin, PS100, epithelial membrane antigen, and calponin.
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20123451 Fanburg-Smith JC, Auerbach A, Marwaha JS, Wang Z, Santi M, Judkins AR, Rushing EJ: Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases. Ann Diagn Pathol. 2010 Feb;14(1):8-14. Epub 2009 Dec 8.


Epithelial membrane antigen (EMA) and desmin were expressed focally in 35% and 50% of cases, respectively.
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17577399 Martorell M, Perez-Valles A, Gozalbo F, Garcia-Garcia JA, Gutierrez J, Gaona J: Solitary fibrous tumor of the thigh with epithelioid features: a case report. Diagn Pathol. 2007 Jun 18;2:19.


Epithelial membrane antigen (EMA) and smooth muscle actin (SMA) may occasionally be expressed.
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