| Name | GTPase |
|---|---|
| Synonyms | RAC3; RAC3; Ras related C3 botulinum substrate 3; Ras related C3 botulinum toxin substrate 3; p21 Rac3; Ras related C3 botulinum substrate 3s; Ras related C3 botulinum toxin substrate 3s; p21 Rac3s… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19940066 | Pattabiraman PP, Rao PV: Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. Am J Physiol Cell Physiol. 2010 Mar;298(3):C749-63. Epub 2009 Nov 25. |
2(0,0,0,2) | Details |
| 18314880 | Lee J, Ko M, Joo CK: Rho plays a key role in TGF-beta1-induced cytoskeletal rearrangement in human retinal pigment epithelium. J Cell Physiol. 2008 Aug;216(2):520-6. We propose that TGF-beta1 induces human RPE cells to undergo cytoskeletal actin rearrangement via Rho GTPase-dependent pathways that modulate LIM kinase and cofilin activity. |
1(0,0,0,1) | Details |
| 17641298 | Kono Y, Nishiuma T, Nishimura Y, Kotani Y, Okada T, Nakamura S, Yokoyama M: Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1. Am J Respir Cell Mol Biol. 2007 Oct;37(4):395-404. Epub 2007 Jul 19. We also detected activation of Rho GTPase upon stimulation of TGF-beta1 on the cell membrane where S1P (2) or S1P (3) was overexpressed. |
1(0,0,0,1) | Details |
| 20064505 | Cheng R, Cheng L, Shao MY, Yang H, Wang FM, Hu T, Zhou XD: Roles of lysophosphatidic acid and the Rho-associated kinase pathway in the migration of dental pulp cells. Exp Cell Res. 2010 Apr 1;316(6):1019-27. Epub 2010 Jan 11. LPA and ROCK inhibition induced activation of another Rho GTPase, Rac, which may explain how LPA and ROCK inhibition increases cellmigration and lamellipodium formation. |
1(0,0,0,1) | Details |
| 18421080 | Meyer-Ter-Vehn T, Katzenberger B, Han H, Grehn F, Schlunck G: Lovastatin inhibits TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3955-60. Epub 2008 Apr 17. HMG--reductase inhibitors (statins) have been shown to inhibit Rho-GTPase signaling; therefore, the authors studied the influence of lovastatin on TGF-beta-mediated myofibroblast transdifferentiation to assess the potential use of statins in wound healing modulation. |
1(0,0,0,1) | Details |
| 19324862 | Chen J, Guerriero E, Sado Y, SundarRaj N: Rho-mediated regulation of TGF-beta1- and FGF-2-induced activation of corneal stromal keratocytes. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3662-70. Epub 2009 Mar 25. PURPOSE: To investigate the role of Rho GTPase signaling in FGF-2- and TGF-beta1-induced activation of corneal keratocytes. |
1(0,0,0,1) | Details |