Protein Information

Name SM22
Synonyms 22 kDa actin binding protein; SM22; SM22 alpha; SMCC; Smooth muscle protein 22 alpha; TAGLN; TAGLN 1; TAGLN1…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18840652 Vaahtomeri K, Ventela E, Laajanen K, Katajisto P, Wipff PJ, Hinz B, Vallenius T, Tiainen M, Makela TP: Lkb1 is required for TGFbeta-mediated myofibroblast differentiation. J Cell Sci. 2008 Nov 1;121(Pt 21):3531-40. Epub 2008 Oct 7.


Recently, it was noted that PJS-type polyps develop in mice in which Lkb1 deletion is restricted to SM22-expressing mesenchymal cells.
2(0,0,0,2) Details
19608972 Grabski AD, Shimizu T, Deou J, Mahoney WM Jr, Reidy MA, Daum G: Sphingosine-1-phosphate receptor-2 regulates expression of smooth muscle alpha-actin after arterial injury. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1644-50. Epub 2009 Jul 16.


In vitro studies using carotid SMCs prepared from wild-type and S1P2R-null mice show that S1P stimulates expression of all SMC-differentiation genes tested, but S1P2R significantly regulates expression of SMA and SM22 alpha only.
1(0,0,0,1) Details
20096071 Yu J, Li Y, Li M, Qu Z, Ruan Q: Oxidized low density lipoprotein-induced transdifferentiation of bone marrow-derived smooth muscle-like cells into foam-like cells in vitro. Int J Exp Pathol. 2010 Feb;91(1):24-33.


After long-term culture with platelet-derived growth factor-BB (PDGF-BB), SMPCs expressed alpha-SMA, SM22 and SM-MHC and differentiated into SMLCs.
1(0,0,0,1) Details
20213136 Langlois D, Hneino M, Bouazza L, Parlakian A, Sasaki T, Bricca G, Li JY: Conditional inactivation of TGF-beta type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects. Transgenic Res. 2010 Mar 6.


All SM22-Cre (+/-)/Tgfbr2 (flox/flox) embryos died during the last third of gestation.
1(0,0,0,1) Details