Protein Information

Name Cx43
Synonyms CX43; Connexin 43; Cx43; DFNB38; GJA 1; GJA1; GJAL; Gap junction 43 kDa heart protein…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18172080 Nakano Y, Oyamada M, Dai P, Nakagami T, Kinoshita S, Takamatsu T: Connexin43 knockdown accelerates wound healing but inhibits mesenchymal transition after corneal endothelial injury in vivo. Invest Ophthalmol Vis Sci. 2008 Jan;49(1):93-104.


PURPOSE: To explore connexin43 (Cx43) knockdown as an efficient treatment for corneal endothelial injury in an in vivo rat corneal scrape injury model.
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18796153 Hutchings G, Gevaert T, Deprest J, Roskams T, Van Lommel A, Nilius B, De Ridder D: Immunohistochemistry using an antibody to unphosphorylated connexin 43 to identify human myometrial interstitial cells. Reprod Biol Endocrinol. 2008 Sep 16;6:43.

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19077877 Ming J, Li T, Zhang Y, Xu J, Yang G, Liu L: Regulatory effects of myoendothelial gap junction on vascular reactivity after hemorrhagic shock in rats. Shock. 2009 Jan;31(1):80-6.


Meanwhile, the relationship of the mRNA/protein expression of connexins 37, 40, and 43 (Cx40 and Cx43) to the changes of vascular reactivity after hemorrhagic shock and the effect of antisense oligodeoxynucleotide of Cx40 or Cx43 on vascular calcium sensitivity and vascular reactivity were investigated.
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19162006 Asazuma-Nakamura Y, Dai P, Harada Y, Jiang Y, Hamaoka K, Takamatsu T: Cx43 contributes to TGF-beta signaling to regulate differentiation of cardiac fibroblasts into myofibroblasts. Exp Cell Res. 2009 Apr 15;315(7):1190-9. Epub 2009 Jan 6.

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18520700 Ming J, Li T, Zhang Y, Xu J, Yang G, Liu L: REGULATORY EFFECTS OF MEGJ ON VASCULAR REACTIVITY FOLLOWING HEMORRHAGIC SHOCK IN RATS. Shock. 2008 May 26.


Meanwhile, the relationship of the mRNA/protein expression of connexins 37, 40, and 43 (Cx40 and Cx43) to the changes of vascular reactivity after hemorrhagic shock and the effect of antisense oligodeoxynucleotide of Cx40 or Cx43 on vascular calcium sensitivity and vascular reactivity were investigated.
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20006013 Nagata K, Masumoto K, Esumi G, Teshiba R, Yoshizaki K, Fukumoto S, Nonaka K, Taguchi T: Connexin43 plays an important role in lung development. J Pediatr Surg. 2009 Dec;44(12):2296-301.


OBJECTIVES: Connexin43 (Cx43) is one of the proteins associated with gap junction.
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18224284 Lopez V, Keen CL, Lanoue L: Prenatal zinc deficiency: influence on heart morphology and distribution of key heart proteins in a rat model. Biol Trace Elem Res. 2008 Jun;122(3):238-55. Epub 2008 Jan 26.


Fetuses were collected on GD 13.5, 15.5, and 18.5 and processed for GATA-4, FOG-2, connexin-43 (Cx43), HNK-1, smooth muscle alpha-actin (SMA) and cleaved caspase-3 protein expression.
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19323797 van Engelen E, Breeveld-Dwarkasing VN, Everts ME, van der Weyden GC, Taverne MA, Rutten VP: Smooth muscle cells of the bovine cervical stroma may have a secretory, rather than a contractile function during parturition. Reprod Domest Anim. 2009 Apr;44(2):303-11.


The smooth muscle bundles of the stroma were immunohistochemically analysed (n = 5) with regard to their integrity and cellular density, and the degree of staining for connexin-43, smooth muscle actin alpha (SMA), desmin and vimentin.
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19836061 Alkafafy M, Elnasharty M, Sayed-Ahmed A, Abdrabou M: Immunohistochemical studies of the epididymal duct in Egyptian water buffalo (Bubalus bubalis). Acta Histochem. 2009 Oct 14.


Primary antibodies against angiotensin converting enzyme (ACE), S-100, galactosyltransferase (GalTase), alpha smooth muscle actin (alpha-SMA), connexin 43 (Cx43) and vascular endothelial growth factor (VEGF) were used for immunohistochemical studies.
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17628769 Neuhaus J, Heinrich M, Schlichting N, Oberbach A, Fitzl G, Schwalenberg T, Horn LC, Stolzenburg JU: [Structure and function of suburothelial myofibroblasts in the human urinary bladder under normal and pathological conditions]. Urologe A. 2007 Sep;46(9):1197-202.


They express Cx43 and form functional syncytia.
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19588758 Ming J, Xu J, Li T, Zhang Y, Yang GM, Liu LM: [Relationship between Cx40/43 regulating the intracellular Ca2+ concentration of vascular smooth muscle cell (VSMC) and endothelium-dependent vascular contractive response of superior mesenteric artery in rats]. Zhonghua Shao Shang Za Zhi. 2009 Feb;25(1):31-5.


Cx40 ASODN increased [Ca2+] i in VSMC and contractive response of SMA towards myricetin, while that of Cx43 ASODN showed opposite tendency.
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