| Name | Hepatocyte growth factor |
|---|---|
| Synonyms | F TCF; HGF; SF; Fibroblast derived tumor cytotoxic factor; HGFB; HPTA; Hepatocyte growth factor; Hepatocyte growth factor precursor… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19680789 | Yang ZJ, Chen B, Sheng Z, Zhang DG, Jia EZ, Wang W, Ma DC, Zhu TB, Wang LS, Li CJ, Wang H, Cao KJ, Ma WZ: Improvement of heart function in postinfarct heart failure swine models after hepatocyte growth factor gene transfer: comparison of low-, medium- and high-dose groups. Mol Biol Rep. 2010 Apr;37(4):2075-81. Epub 2009 Aug 13. |
3(0,0,0,3) | Details |
| 18988920 | Shukla MN, Rose JL, Ray R, Lathrop KL, Ray A, Ray P: Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad7. Am J Respir Cell Mol Biol. 2009 Jun;40(6):643-53. Epub 2008 Nov 6. |
2(0,0,0,2) | Details |
| 18763191 | Jiang D, Jiang Z, Li Z, Zhang Y: Suppression of the production of extracellular matrix and alpha-smooth muscle actin induced by transforming growth factor-beta1 in fibroblasts of the flexor tendon sheath by hepatocyte growth factor. Scand J Plast Reconstr Surg Hand Surg. 2008;42(4):169-73. |
2(0,0,0,2) | Details |
| 19292056 | Zuo C, Qiu HY, Xie XS, Deng Y, Fan JM: [Effect of Astragalus mongholicus on expression of hepatocyte growth factor in SD rats with unilateral ureteral obstruction]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Jan;40(1):100-5. |
2(0,0,0,2) | Details |
| 20025519 | Yu Y, Lv L, Qian X, Chen N, Yao A, Pu LY, Zhang F, Li XC, Kong LB, Sun BC, Wang X: Anti-fibrotic Effect of Hepatocyte Growth Factor-expressing Mesenchymal Stem Cells in Small-for-size Liver Transplant Rats. Stem Cells Dev. 2009 Dec 21. |
2(0,0,0,2) | Details |
| 18692530 | Li F, Sun JY, Wang JY, Du SL, Lu WY, Liu M, Xie C, Shi JY: Effect of hepatocyte growth factor encapsulated in targeted liposomes on liver cirrhosis. J Control Release. 2008 Oct 6;131(1):77-82. Epub 2008 Jul 20. |
2(0,0,0,2) | Details |
| 18273647 | Kawasaki Y, Imaizumi T, Matsuura H, Ohara S, Takano K, Suyama K, Hashimoto K, Nozawa R, Suzuki H, Hosoya M: Renal expression of alpha-smooth muscle actin and c-Met in children with Henoch-Schonlein purpura nephritis. Pediatr Nephrol. 2008 Jun;23(6):913-9. On the other hand, c-Met is the receptor for hepatocyte growth factor (HGF), which plays a role in protection from injury and has anti-fibrogenetic effects. |
1(0,0,0,1) | Details |
| 18522880 | Zheng JF, Liang LJ: Intra-portal transplantation of bone marrow stromal cells ameliorates liver fibrosis in mice. Hepatobiliary Pancreat Dis Int. 2008 Jun;7(3):264-70. RESULTS: BMSCs were shown to differentiate into hepatocyte-like phenotypes after hepatocyte growth factor treatment in vitro. |
1(0,0,0,1) | Details |
| 18063891 | Jun EJ, Kim HS, Kim YH: Role of HGF/c-Met in serum-starved ARPE-19 cells. Korean J Ophthalmol. 2007 Dec;21(4):244-50. PURPOSE: Hepatocyte growth factor (HGF) and its receptor (HGFR/c-Met) regulate motility, mitogenesis, and morphogenesis in a cell type-dependent fashion. |
1(0,0,0,1) | Details |
| 17990457 | Liu YM, Zhang Y, He LQ: [Experimental study on effect of Kangxianling on rat renal interstitial fibrosis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Oct;27(10):901-4. Then rats were sacrificed, their renal pathology examined by HE staining and PASM staining; expressions of transforming growth factor-beta1 (TGF-beta1), hepatocyte growth factor (HGF) mRNA, and a-smooth muscle actin (alpha-SMA), TGF-beta1 receptor I (TbetaR I), TGF-beta1 receptor II (TbetaR II) and hepatocyte growth factor receptor (C-Met) protein in kidney tissue were determined by RT-PCR and Western blotting respectively. |
1(0,0,0,1) | Details |
| 19085956 | Asahina K, Tsai SY, Li P, Ishii M, Maxson RE Jr, Sucov HM, Tsukamoto H: Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009 Mar;49(3):998-1011. The ALCAM (+) cells expressed hepatocyte growth factor and pleiotrophin. |
1(0,0,0,1) | Details |
| 19134281 | WANG W, WU SM, ZHANG ZM, ZHANG YQ: [In vivo transfection of hepatocyte growth factor gene induces pulmonary angiogenesis in rabbits with hyperkinetic pulmonary hypertension]. Zhonghua Xin Xue Guan Bing Za Zhi. 2008 Dec;36(12):1110-4. |
1(0,0,0,1) | Details |
| 19193779 | Yu MA, Shin KS, Kim JH, Kim YI, Chung SS, Park SH, Kim YL, Kang DH: HGF and BMP-7 ameliorate high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelium. J Am Soc Nephrol. 2009 Mar;20(3):567-81. Epub 2009 Feb 4. In addition, exposure of HPMC to high resulted in a decreased expression of the antifibrotic cytokines, hepatocyte growth factor (HGF) and bone morphogenic protein 7 (BMP-7). |
1(0,0,0,1) | Details |
| 19781102 | Yao Q, Qu X, Yang Q, Good DA, Dai S, Kong B, Wei MQ: Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models. Mol Cancer. 2009 Sep 27;8:78. Down-regulation of CLIC4 with a generic agent or specific siRNA both significantly reduces the expression of factors related to the phenotypes and functions of myofibroblasts, such as alpha-SMA, hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF), thus reversing the myofibroblast phenotype back to fibroblasts. |
1(0,0,0,1) | Details |
| 18784150 | Silver RM, Wells AU: Histopathology and bronchoalveolar lavage. Rheumatology. 2008 Oct;47 Suppl 5:v62-4. Analysis of BALF suggests an imbalance between pro-fibrotic and anti-fibrotic factors, e.g. an overabundance of TGF-beta, connective tissue growth factor (CTGF), PDGF, leucotriene B4, etc. and in some cases a deficiency of hepatocyte growth factor, (15-HETE), lipoxin A, etc. |
1(0,0,0,1) | Details |
| 17976157 | Hagiwara S, Otsuka T, Yamazaki Y, Kosone T, Sohara N, Ichikawa T, Sato K, Kakizaki S, Takagi H, Mori M: Overexpression of NK2 promotes liver fibrosis in carbon tetrachloride-induced chronic liver injury. Liver Int. 2008 Jan;28(1):126-31. Epub 2007 Nov 1. BACKGROUND/AIMS: Hepatocyte growth factor (HGF) inhibits liver fibrosis induced by carbon tetrachloride (CCl4) in animal models. |
1(0,0,0,1) | Details |
| 19434765 | Zuo C, Xie XS, Qiu HY, Deng Y, Zhu D, Fan JM: Astragalus mongholicus ameliorates renal fibrosis by modulating HGF and TGF-beta in rats with unilateral ureteral obstruction. J Zhejiang Univ Sci B. 2009 May;10(5):380-90. The expressions of fibronectin (FN), type I collagen (colI), hepatocyte growth factor (HGF), transforming growth factor-beta1 (TGF-beta1), and alpha-smooth muscle actin (alpha-SMA) were analyzed by real-time polymerase chain reaction (PCR), immunohistochemistry staining, and Western blot. |
1(0,0,0,1) | Details |
| 20013848 | Kumai Y, Kobler JB, Park H, Galindo M, Herrera VL, Zeitels SM: Modulation of vocal fold scar fibroblasts by adipose-derived stem/stromal cells. Laryngoscope. 2010 Feb;120(2):330-7. OBJECTIVES/HYPOTHESIS: To explore whether adipose-derived stem/stromal cells (ASCs) have therapeutic potential for treating scarred superficial lamina propria through the effects of secreted hepatocyte growth factor (HGF) on scar fibroblasts. |
1(0,0,0,1) | Details |