Protein Information

Name P27
Synonyms FAM14D; p27; IFI27; ISG12; ISG12(a) protein; Interferon alpha induced 11.5 kDa protein; Interferon alpha inducible protein 27; ISG12(a) proteins…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19114984 Liu Y, Lui EL, Friedman SL, Li L, Ye T, Chen Y, Poon RT, Wo J, Kok TW, Fan ST: PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling. Lab Invest. 2009 Feb;89(2):209-21. Epub 2008 Dec 29.


PTK/ZK also induced cell cycle arrest, accompanied by increasing the expression of p27 (Kip1) and downregulation of cyclin D1 and cyclin E.
1(0,0,0,1) Details
20199810 Chou MT, Chang SN, Ke C, Chang HI, Sung ML, Kuo HC, Chen CN: The proliferation and differentiation of placental-derived multipotent cells into smooth muscle cells on fibrillar collagen. Biomaterials. 2010 May;31(15):4367-75. Epub 2010 Mar 3.


Polymerized collagen increased the expressions of p21 (CIP1) and p27 (KIP1); decreased cyclin A, cyclin D1, cyclin-dependent protein kinase 2 (Cdk2); and led to G (0)/G (1) arrest in PDMCs.
1(0,0,0,1) Details
19819988 Chang SF, Chang TK, Peng HH, Yeh YT, Lee DY, Yeh CR, Zhou J, Cheng CK, Chang CA, Chiu JJ: BMP-4 induction of arrest and differentiation of osteoblast-like cells via p21 CIP1 and p27 KIP1 regulation. Mol Endocrinol. 2009 Nov;23(11):1827-38. Epub 2009 Oct 9.

Using specific small interfering RNA (siRNA), we found that BMP-4-induced G (0)/G (1) arrest, and p21 (CIP1) and p27 (KIP1) expressions were mediated by BMP receptor type IA (BMPRIA)-specific Sma- and Mad-related protein (Smad) 1/5.
83(1,1,1,3) Details