Protein Information

Name bone morphogenetic protein 7
Synonyms BMP 7; BMP7; Bone morphogenetic protein 7; Bone morphogenetic protein 7 precursor; Eptotermin alfa; OP 1; OP1; Osteogenic protein 1…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19180920 He CM, Zheng FL, Lian YG, Liu YP: [Relationship between the effect of vascular endothelial growth factor on epithelial-mesenchymal transition of HK-2 cells and the expressions of bone morphogenetic protein-7 and inhibitor of DNA binding/differentiation]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008 Dec;30(6):703-10.

2(0,0,0,2) Details
20349724 Zhou J, Wang F, Lu H, Zhang Y: [Impact of salvianolic acid-B on TGF-beta1-induced HK-2 epithelial-mesenchymal transition]. Zhongguo Zhong Yao Za Zhi. 2010 Jan;35(1):89-93.


At the same time bone morphogenetic protein-7 (BMP-7, positive control) and the SA-B intervention were given to observe their effect on EMT.
1(0,0,0,1) Details
19557718 Xu Y, Wan J, Jiang D, Wu X: BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition in human renal proximal tubular epithelial cells. J Nephrol. 2009 May-Jun;22(3):403-10.


Bone morphogenetic protein-7 (BMP-7) is a member of the TGF-beta superfamily.
1(0,0,0,1) Details
18455002 Carvajal G, Droguett A, Burgos ME, Aros C, Ardiles L, Flores C, Carpio D, Ruiz-Ortega M, Egido J, Mezzano S: Gremlin: a novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy. Transplant Proc. 2008 Apr;40(3):734-9.


It has been proposed that the bone morphogenetic protein 7 (BMP-7) antagonist, Gremlin, could participate in EMT, as a downstream mediator of TGF-beta.
1(0,0,0,1) Details
17933841 Li M, Hering-Smith KS, Simon EE, Batuman V: Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells. Nephrol Dial Transplant. 2008 Mar;23(3):860-70. Epub 2007 Oct 12.


The use of bone morphogenetic protein-7 or pituitary adenylate cyclase-activating polypeptide (PACAP) induced the formation of cell aggregates, and the reacquisition of E-cadherin expression and renal proximal tubule epithelial morphology within the confluent cell monolayer during and after LC exposure.
1(0,0,0,1) Details
19056781 Dudas PL, Argentieri RL, Farrell FX: BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells. Nephrol Dial Transplant. 2009 May;24(5):1406-16. Epub 2008 Dec 4.


BACKGROUND: In rodent models of chronic renal disease bone morphogenetic protein-7 (BMP-7) has been shown to halt disease progression and promote recovery.
1(0,0,0,1) Details
19816049 Xu Y, Wan J, Jiang D, Wu X: BMP-7 blocks the cyclosporine-A-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells. Nephron Exp Nephrol. 2010;114(1):e23-31. Epub 2009 Oct 9.


Bone morphogenetic protein (BMP-7) has been reported to protect against and reverse renal injury via its renotropic and antifibrotic effects.
1(0,0,0,1) Details
19217158 Zhang H, Tasnim F, Ying JY, Zink D: The impact of extracellular matrix coatings on the performance of human renal cells applied in bioartificial kidneys. Biomaterials. 2009 May;30(15):2899-911. Epub 2009 Feb 12.


ECM coatings were tested alone or in combination with the growth factor bone morphogenetic protein-7 and other additives.
1(0,0,0,1) Details