Protein Information

Name COL1A1
Synonyms COL1A1; Collagen alpha 1(I) chain; Collagen alpha 1(I) chain precursor; OI4; Collagen alpha 1(I) chains; Collagen alpha 1(I) chain precursors

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17868111 Fu SC, Cheuk YC, Chan KM, Hung LK, Wong MW: Is cultured tendon fibroblast a good model to study tendon healing? . J Orthop Res. 2008 Mar;26(3):374-83.


The mRNA expression of COL1A1, COL3A1, decorin, and biglycan, with or without supplementation of 1 ng/mL TGF-beta1, was compared by quantitative real-time RT-PCR.
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19250650 Urtasun R, Cubero FJ, Vera M, Nieto N: Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha. Gastroenterology. 2009 Apr;136(4):1410-22

Western blot, nuclear in vitro transcription, Northern blot, qPCR, and promoter transactivation analysis for COL1A1 and COL1A2 were carried out.
There was a time- and dose-dependent down-regulation of collagen I and alpha-Sma proteins and up-regulation of MMP1 and TNFalpha, indicating decreased HSC activation.
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19914391 Perez-Carreon JI, Martinez-Perez L, Loredo ML, Yanez-Maldonado L, Velasco-Loyden G, Vidrio-Gomez S, Ramirez-Salcedo J, Hernandez-Luis F, Velazquez-Martinez I, Suarez-Cuenca JA, Hernandez-Munoz R, de Sanchez VC: An adenosine derivative compound, IFC305, reverses fibrosis and alters gene expression in a pre-established CCl (4)-induced rat cirrhosis. Int J Biochem Cell Biol. 2010 Feb;42(2):287-96. Epub 2009 Nov 13.


Some genes modulated at transcript level by IFC305 were Tgfb1, Fn1, Col1a1, C9, Apoa1, Ass1, Cps1, and Pparg.
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