Protein Information

Name smoothelin
Synonyms SMSMO; SMTN; Smoothelin; Smoothelin B3; Smoothelins; Smoothelin B3s

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18936687 Paner GP, Shen SS, Lapetino S, Venkataraman G, Barkan GA, Quek ML, Ro JY, Amin MB: Diagnostic utility of antibody to smoothelin in the distinction of muscularis propria from muscularis mucosae of the urinary bladder: a potential ancillary tool in the pathologic staging of invasive urothelial carcinoma. Am J Surg Pathol. 2009 Jan;33(1):91-8.

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18294308 Nolazco G, Kovanecz I, Vernet D, Gelfand RA, Tsao J, Ferrini MG, Magee T, Rajfer J, Gonzalez-Cadavid NF: Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. BJU Int. 2008 May;101(9):1156-64. Epub 2008 Feb 21.


RESULTS: The exogenous cells replicated and converted into SMCs, as shown in corporal tissue sections by confocal immunofluorescence microscopy for proliferating cell nuclear antigen (PCNA), alpha SMA, and smoothelin, and also by Western blot for alpha SMA and PCNA.
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18845763 Kim MR, Jeon ES, Kim YM, Lee JS, Kim JH: Thromboxane a (2) induces differentiation of human mesenchymal stem cells to smooth muscle-like cells. Stem Cells. 2009 Jan;27(1):191-9.


In the present study, we demonstrate for the first time that the TxA (2) mimetic U46619 induces differentiation of human adipose tissue-derived MSCs (hADSCs) to smooth muscle-like cells, as demonstrated by increased expression of smooth muscle-specific contractile proteins such as alpha-smooth muscle actin (alpha-SMA), calponin, smoothelin, and smooth muscle-myosin heavy chain.
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