Protein Information

Name RANTES
Synonyms CC chemokine ligand 5; CCL 5; CCL5; D17S136E; RANTES; SCYA 5; SCYA5; SIS delta…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17585540 Stasikowska O, Danilewicz M, Wagrowska-Danilewicz M: The significant role of RANTES and CCR5 in progressive tubulointerstitial lesions in lupus nephropathy. Pol J Pathol. 2007;58(1):35-40.

6(0,0,0,6) Details
20007519 McNearney TA, Ma Y, Chen Y, Taglialatela G, Yin H, Zhang WR, Westlund KN: A peripheral neuroimmune link: glutamate agonists upregulate NMDA NR1 receptor mRNA and protein, vimentin, TNF-alpha, and RANTES in cultured human synoviocytes. Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R584-98. Epub 2009 Dec 9.

3(0,0,0,3) Details
20232302 Roson MI, Della Penna SL, Cao G, Gorzalczany S, Pandolfo M, Toblli JE, Fernandez BE: Different protective actions of losartan and tempol on the renal inflammatory response to acute sodium overload. J Cell Physiol. 2010 Mar 15.


Ang II, NF-kappaB, hypoxia inducible factor-1alpha (HIF-1alpha), transforming growth factor beta1 (TGF-beta1), smooth muscle actin (alpha-SMA), endothelial nitric oxide synthase (eNOS), and RANTES renal expression was evaluated by immunohistochemistry.
3(0,0,0,3) Details
20159698 He Y, Chen BL, Yang RP, Ren M, Zeng ZR: [Comparison of the pathogenesis of liver fibrosis induced by pig serum exposure and bile duct ligation in rats.]. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Feb;30(2):270-4.


Quantitative real time PCR (qPCR) analysis was employed to quantify the mRNA expression of the genes related to inflammation, including interleukin-1beta (IL-1beta), IL-6, monocyte chemotactic protein-1, tumor necrosis factor-alpha, regulated upon activation normal T cell expressed and secreted (RANTES), transforming growth factor-beta, platelet-derived growth factor A, as well as the genes associated with fibrogenesis, namely collagen 1, alphaSMA, MMP-9 and TIMP-1.
2(0,0,0,2) Details
19840961 Jungraithmayr W, Vogt P, Inci I, Hillinger S, Arni S, Passlick B, Korom S, Weder W: A model of chronic lung allograft rejection in the rat. Eur Respir J. 2009 Oct 20.


At day 84, fibrotic lesions replaced the respiratory epithelium within small bronchioles with strong expression of alpha-SMA and upregulated mRNA for Th1-cytokines, alpha-SMA, TGF-beta and CCL5 but decreased gene expression for FOXP3.We describe a reproducible and clinically relevant experimental setup for progressive chronic rejection in rat pulmonary allografts.
1(0,0,0,1) Details
19100385 Watson MJ, Ke B, Shen XD, Gao F, Busuttil RW, Kupiec-Weglinski JW, Farmer DG: Intestinal ischemia/reperfusion injury triggers activation of innate toll-like receptor 4 and adaptive chemokine programs. Transplant Proc. 2008 Dec;40(10):3339-41.


Additionally, mRNA production of IP-10, MIP-2, MCP-1, and RANTES was increased at all time-points, as was mRNA for ICAM-1 and E-selectin.
1(0,0,0,1) Details
17997848 Armah HB, Wilson NO, Sarfo BY, Powell MD, Bond VC, Anderson W, Adjei AA, Gyasi RK, Tettey Y, Wiredu EK, Tongren JE, Udhayakumar V, Stiles JK: Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. Malar J. 2007 Nov 12;6:147.


Serum and CSF levels of 36 different biomarkers (IL-1beta, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17, Eotaxin, FGF basic protein, CRP, G-CSF, GM-CSF, IFN-gamma, TNF-alpha, IP-10, MCP-1 (MCAF), MIP-1alpha, MIP-1beta, RANTES, SDF-1alpha, CXCL11 (I-TAC), Fas-ligand [Fas-L], soluble Fas [sFas], sTNF-R1 (p55), sTNF-R2 (p75), MMP-9, TGF-beta1, PDGF bb and VEGF) were measured and the results compared between the 3 groups.
1(0,0,0,1) Details
19159945 Tamura M, Aizawa R, Hori M, Ozaki H: Progressive renal dysfunction and macrophage infiltration in interstitial fibrosis in an adenine-induced tubulointerstitial nephritis mouse model. Histochem Cell Biol. 2009 Apr;131(4):483-90. Epub 2009 Jan 22.


In renal tissue, mRNA expression of MCP-1, MIP-1alpha, RANTES, IL-1beta, CCR2, TGF-beta, alpha-smooth muscle actin (alpha-SMA) and collagen 1a1 was increased in parallel.
1(0,0,0,1) Details
19589538 Liu M, Gu M, Wu Y, Zhu P, Zhang W, Yin C, Zhang WJ: Therapeutic effect of Y-27632 on chronic allograft nephropathy in rats. J Surg Res. 2009 Nov;157(1):e117-27. Epub 2008 Nov 24.


This was associated with down-regulation of the expression of tubular monocyte chemoattractant protein-1, RANTES (regulated upon expression normal T cell expressed and secreted), and phosphorylated NF-kappaB (which was a marker for activation).
1(0,0,0,1) Details