Protein Information

Name NFkappaB (protein family or complex)
Synonyms NF kappa B; NFKB; NFkappaB; Nuclear factor NF kappa B

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18515844 Miyake T, Aoki M, Morishita R: Inhibition of anastomotic intimal hyperplasia using a chimeric decoy strategy against NFkappaB and E2F in a rabbit model. Cardiovasc Res. 2008 Sep 1;79(4):706-14. Epub 2008 May 31.

3(0,0,0,3) Details
18477569 Kihm LP, Wibisono D, Muller-Krebs S, Pfisterer F, Morath C, Gross ML, Morcos M, Seregin Y, Bierhaus A, Nawroth PP, Zeier M, Schwenger V: RAGE expression in the human peritoneal membrane. Nephrol Dial Transplant. 2008 Oct;23(10):3302-6. Epub 2008 May 13.


Additionally, in 4 of the 48 uraemic patients, peritoneal biopsies were repeated after 15 months at the time of catheter removal to analyse the above parameters and the extent of NFkappaB-binding activity determined by electrophoretic mobility shift assay (EMSA) in the long-term follow-up.
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19376089 Szuster-Ciesielska A, Plewka K, Daniluk J, Kandefer-Szerszen M: Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling. Biochem Pharmacol. 2009 Aug 1;78(3):301-14. Epub 2009 Apr 17.


Intracellular signals such as nuclear factor-kappaB (NFkappaB), C-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) induced by ethanol and its metabolite were also assessed.
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18662738 Wojcikowski K, Wohlmuth H, Johnson DW, Gobe G: Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways. Food Chem Toxicol. 2008 Sep;46(9):3122-31. Epub 2008 Jul 10.


Protein expression levels of the pro-inflammatory cytokine, TNF-alpha, the pro-fibrotic transcription factor, NFkappaB, a measure of oxidative stress (heme oxygenase-1), alpha-SMA, vimentin and TGFss1 were determined.
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19723340 Weng TC, Shen CC, Chiu YT, Lin YL, Kuo CD, Huang YT: Inhibitory effects of armepavine against hepatic fibrosis in rats. J Biomed Sci. 2009 Sep 2;16:78.


Arm also suppressed TNF-alpha-induced collagen collagen deposition, NFkappaB activation and MAPK (p38, ERK1/2, and JNK) phosphorylations.
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