Protein Information

Name keratins (protein family or complex)
Synonyms Keratin; Keratins

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19542912 Plaza JA, Torres-Cabala C, Evans H, Diwan AH, Prieto VG: Immunohistochemical expression of S100A6 in cellular neurothekeoma: clinicopathologic and immunohistochemical analysis of 31 cases. Am J Dermatopathol. 2009 Jul;31(5):419-22.


In addition, 8 cases were evaluated for HMB-45 antigen, keratin (with a pankeratin cocktail), epithelial membrane (EMA), and smooth muscle antigen (SMA).
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19577381 Fraternali Orcioni G, Louis Ravetti J, Gaggero G, Bocca B, Bisceglia M: Primary embryonal spindle cell cardiac rhabdomyosarcoma: Case report. Pathol Res Pract. 2009 Jul 2.


Staining for alpha-SMA, H-caldesmon, CD34, epithelial membrane antigen (EMA), keratin wide-spectrum (CK w.s.), and S100 protein was negative.
1(0,0,0,1) Details
18941404 Westfall DE, Folpe AL, Paner GP, Oliva E, Goldstein L, Alsabeh R, Gown AM, Amin MB: Utility of a comprehensive immunohistochemical panel in the differential diagnosis of spindle cell lesions of the urinary bladder. Am J Surg Pathol. 2009 Jan;33(1):99-105.


Positivity for keratin was typically focal to moderate in smooth muscle tumors and more commonly moderate to diffuse in sarcomatoid carcinomas and PMP.
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18442419 Markopoulos C, Mantas D, Philipidis T, Kouskos E, Antonopoulou Z, Hatzinikolaou M, Gogas H: Glycogen-rich clear cell carcinoma of the breast. . World J Surg Oncol. 2008 Apr 29;6:44.


Diagnosis of clear cell carcinoma was based on certain histological characteristics of the tumour and immunohistochemical analysis (PAS staining, keratins AE1/AE3, EMA, cytokeratin 7, cytokeratin 20, melanosomes, vimentin, Chromogranin, Synaptophysin, S-100, SMA).
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19862337 Barbaro V, Ferrari S, Fasolo A, Ponzin D, Di Iorio E: Reconstruction of a human hemicornea through natural scaffolds compatible with the growth of corneal epithelial stem cells and stromal keratocytes. Mol Vis. 2009 Oct 17;15:2084-93.


The effects of the scaffold on the preservation of stemness and/or induction of differentiation pathways were investigated through analysis of a variety of markers, including p63 and DeltaNp63alpha for stemness, 14-3-3sigma for early differentiation, keratins 3, 14, 12, and 19 to determine cell phenotype, and alpha6, beta1, and beta4 integrins to evaluate interactions with the stroma.
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17650214 Rizkalla H, Toner M: Necrotizing sialometaplasia versus invasive carcinoma of the head and neck: the use of myoepithelial markers and keratin subtypes as an adjunct to diagnosis. Histopathology. 2007 Aug;51(2):184-9.

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19323373 Qi XP, Lin GB, Zhu YL, Wang JQ, Dai XW, Ma JM, Yan L: [Pseudoangiosarcomatous squamous cell carcinoma of the penis: a case report with clinicopathological and human papilloma virus analyses]. Zhonghua Nan Ke Xue. 2009 Feb;15(2):134-9.


Immunohistochemically, most tumor cells were strongly positive for keratin (AE1/AE3) and focally positive for EMA, with the typical squamous cells focally positive for 34betaE12 and vimentin.
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18021353 Lavranos G, Paschalis G, Angelopoulou R, Karandrea D, Goutas N: Casual discovery of a thoracic tumour showing histological features of undifferentiated pleomorphic sarcoma in a male Wistar laboratory rat. Anat Histol Embryol. 2007 Dec;36(6):433-6.


Immunohistochemistry was performed on the tissue using specific antibodies for several proliferation (Ki-67) and differentiation (S-100, CD-34, CD-68, pan-keratin, desmin and smooth muscle actin-SMA) markers.
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19855377 Thike AA, Cheok PY, Jara-Lazaro AR, Tan B, Tan P, Tan PH: Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer. Mod Pathol. 2010 Jan;23(1):123-33. Epub 2009 Oct 23.


Using a set of 61 invasive breast cancers earlier profiled into molecular subtypes with expression arrays, we defined specificity and sensitivity values for different immunohistochemical panels of basal keratins (CK5/6, CK14, CK17, 34 beta E12), CD117, EGFR, p63 and SMA in defining basal-like breast cancer.
1(0,0,0,1) Details