Protein Information

Name adrenomedullin
Synonyms ADM; PAMP; ADM precursor; AM; Adrenomedullin; ProAM N terminal 20 peptide; ProAM N20; Proadrenomedullin N 20 terminal peptide…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17660075 Dwivedi AJ, Wu R, Nguyen E, Higuchi S, Wang H, Krishnasastry K, Marini CP, Ravikumar TS, Wang P: Adrenomedullin and adrenomedullin binding protein-1 prevent acute lung injury after gut ischemia-reperfusion. J Am Coll Surg. 2007 Aug;205(2):284-93. Epub 2007 Jun 21.

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18787625 Higuchi S, Wu R, Zhou M, Marini CP, Ravikumar TS, Wang P: Gut hyperpermiability after ischemia and reperfusion: attenuation with adrenomedullin and its binding protein treatment. Int J Clin Exp Pathol. 2008 Jan 1;1(5):409-18.

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19427769 Park JK, Hong IH, Goo MJ, Ki MR, Hong KS, Hwang OK, Han JY, Ji AR, Park SI, Jeong KS: Subcutaneous leiomyosarcoma in an adrenomedullin heterozygous mouse. Exp Toxicol Pathol. 2009 May 9.

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18050204 Clancy RM, Zheng P, O'Mahony M, Izmirly P, Zavadil J, Gardner L, Buyon JP: Role of hypoxia and cAMP in the transdifferentiation of human fetal cardiac fibroblasts: implications for progression to scarring in autoimmune-associated congenital heart block. Arthritis Rheum. 2007 Dec;56(12):4120-31.


Hypoxia-exposed cardiac fibroblasts expressed adrenomedullin at 4-fold increased levels, as determined by Affymetrix array, quantitative PCR, and immunofluorescence, thus focusing attention on cAMP as a modulator of fibrosis.
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