Protein Information

Name angiopoietin 1
Synonyms AGP1; AGP1; Ang1; AGPT; ANG 1; ANGPT 1; ANGPT1; Angiopoietin 1 precursor…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19371232 Lubel JS, Herath CB, Tchongue J, Grace J, Jia Z, Spencer K, Casley D, Crowley P, Sievert W, Burrell LM, Angus PW: Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat. Clin Sci. 2009 Sep 14;117(11):375-86.


Ang-(1-7) (angiotensin-1-7), a peptide product of the recently described ACE (angiotensin-converting enzyme) homologue ACE2, opposes the harmful actions of AngII (angiotensin II) in cardiovascular tissues, but its role in liver disease is unknown.
9(0,0,0,9) Details
19567053 Li C, Zhang B, Wang ZH, Chen JC, Li B, Wang SX, Chen J, Li CH, Wang W, Song YF: [Significance of a reversal expression of the angiopoietin-1 and 2 in oral squamous cell carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 May;44(5):412-8.

8(0,0,0,8) Details
19403408 Ying SS, Li X, Huang ML, Meng Y, Zhang ZS: [Effect of angiotensin1-7 on alpha-smooth muscle actin protein expression in rat hepatic stellate cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2009 Apr;29(4):732-3.


METHODS: HSC-T6 cells were treated with 10 micromol/L of AngII, Ang1-7, AngII +Ang1-7, and Ang1-7+A779.
4(0,0,0,4) Details
19650157 Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA: Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep;50(3):929-38.


The aim of this study was to characterize the long-term effects of gene deletion of ACE2 in the liver, to define the role of ACE2 in acute and chronic liver disease, and to characterize the role of Ang (1-7) in hepatic stellate cell (HSC) activation.
2(0,0,0,2) Details
17849463 Tilki D, Kilic N, Sevinc S, Zywietz F, Stief CG, Ergun S: Zone-specific remodeling of tumor blood vessels affects tumor growth. Cancer. 2007 Nov 15;110(10):2347-62.


Also, Ang1 immunostaining was strongest in large vessels of TIZ and TCZ, whereas Ang2 staining was prominent in small vessels of TIZ.
1(0,0,0,1) Details
17935226 Tugues S, Fernandez-Varo G, Munoz-Luque J, Ros J, Arroyo V, Rodes J, Friedman SL, Carmeliet P, Jimenez W, Morales-Ruiz M: Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology. 2007 Dec;46(6):1919-26.


Cirrhosis progression was associated with a significant enhancement of vascular density and expression of vascular endothelial growth factor-A, angiopoietin-1, angiopoietin-2, and placental growth factor in cirrhotic livers.
1(0,0,0,1) Details
18316579 Zhou Q, Guo P, Gallo JM: Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide. Clin Cancer Res. 2008 Mar 1;14(5):1540-9.


Furthermore, both sunitinib-treated groups maintained the molecular balance between angiopoietins Ang-1 and Ang-2, suggesting a critical role of angiopoietins in vascular normalization.
1(0,0,0,1) Details