Protein Information

Name S100
Synonyms NEF; S100; Protein S100 B; S 100 protein beta chain; S 100 protein beta subunit; S100 beta; S100 calcium binding protein B; S100B…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19093260 Hornychova H, Melichar B, Tomsova M, Mergancova J, Urminska H, Ryska A: Tumor-infiltrating lymphocytes predict response to neoadjuvant chemotherapy in patients with breast carcinoma. Cancer Invest. 2008 Dec;26(10):1024-31.

In the remaining 63 patients, a significant decrease in the percentage of Ki-67, vascular endothelial growth factor expression, CD68 (+) monocytes, and increased CD31 (+), CD34 (+), and SMA (+) stromal vessels, maximal CD3 (+) and CD56 (+) lymphocyte, maximal and mean CD83 (+) cell, maximal CD1a (+), and maximal and mean S100 (+) cell counts were observed after neoadjuvant chemotherapy.
6(0,0,1,1) Details
20013263 Knosel T, Schulz B, Katenkamp K, Katenkamp D, Petersen I: [Solitary fibrous tumor and haemangiopericytoma: what is new?] . Pathologe. 2010 Mar;31(2):123-8.

In this study 268 intrathoracic and extrathoracic SFTs from the German consultation and reference center of soft tissue tumors in Jena were evaluated and analyzed immunohistochemically with antibodies CD34, Bcl-2, CD99, SMA, S100, PanCK and Ki-67.
6(0,0,1,1) Details
20123583 Chou CC, Chou MJ, Tzen CY: Prediction of KIT mutation in gastrointestinal stromal tumors by the immunoprofile of the tumor cells. J Formos Med Assoc. 2010 Jan;109(1):25-31.


METHODS: One hundred and forty-nine GIST were subjected to mutation analysis for KIT and immunohistochemical analysis for the expression of CD117, CD34, alpha-smooth muscle actin (SMA), and S100 protein.
3(0,0,0,3) Details
17650214 Rizkalla H, Toner M: Necrotizing sialometaplasia versus invasive carcinoma of the head and neck: the use of myoepithelial markers and keratin subtypes as an adjunct to diagnosis. Histopathology. 2007 Aug;51(2):184-9.


METHODS AND RESULTS: Thirteen cases with the histological changes of NSM, eight SCCs and eight MECs were examined with the following immunohistochemical markers: calponin, S100, smooth muscle actin (SMA), p63, CK7, CK5, CK6 and CAM5.2.
2(0,0,0,2) Details
19542912 Plaza JA, Torres-Cabala C, Evans H, Diwan AH, Prieto VG: Immunohistochemical expression of S100A6 in cellular neurothekeoma: clinicopathologic and immunohistochemical analysis of 31 cases. Am J Dermatopathol. 2009 Jul;31(5):419-22.


Immunohistochemical studies were performed in all 31 cases with formalin-fixed paraffin-embedded tissue sections with antibodies against S100 protein, S100A6, and melanoma antigen recognized by T-cells (MART-1).
2(0,0,0,2) Details
19524557 Smithson LJ, Kawaja MD: A comparative examination of biomarkers for olfactory ensheathing cells in cats and guinea pigs. Brain Res. 2009 Aug 11;1284:41-53. Epub 2009 Jun 11.


Three conventional biomarkers for OECs, p75 neurotrophin receptor (p75NTR), S100, and glial fibrillary acidic protein (GFAP), as well as two recently identified biomarkers, smooth muscle alpha-actin (SMA) and calponin, were used.
2(0,0,0,2) Details
18841827 Di Blasi A, Ferrara G, Antinolfi G, Dalena AM, Antinolfi F: [Clear cell adenomyoepithelioma of the ceruminous gland] . Pathologica. 2008 Jun;100(3):192-6.


Clear cells were weakly positive for CK18 and strongly positive for vimentin; they also displayed S100 protein and focal GFAP immunoreactivity.
1(0,0,0,1) Details
19577381 Fraternali Orcioni G, Louis Ravetti J, Gaggero G, Bocca B, Bisceglia M: Primary embryonal spindle cell cardiac rhabdomyosarcoma: Case report. Pathol Res Pract. 2009 Jul 2.


Staining for alpha-SMA, H-caldesmon, CD34, epithelial membrane antigen (EMA), keratin wide-spectrum (CK w.s.), and S100 protein was negative.
1(0,0,0,1) Details
17883045 Paul PC, Chakraborty J, Kundu D, Sarkar R: Gastro-intestinal stromal tumour--role of CD117 in diagnosis and management. Indian J Pathol Microbiol. 2007 Apr;50(2):279-83.


Only 4 cases were CDll7 positive, one case was positive for S100 and one case for SMA.
1(0,0,0,1) Details
20004561 Katori Y, Cho BH, Song CH, Fujimiya M, Murakami G, Kawase T: Smooth-to-striated muscle transition in human esophagus: an immunohistochemical study using fetal and adult materials. Ann Anat. 2010 Feb 20;192(1):33-41. Epub 2009 Nov 10.


METHODS: In horizontal sections of 10 human fetuses between 9 and 16 weeks of gestation, we identified immunoreactivity for smooth muscle actin (SMA), striated muscle myosin heavy chain (MyH), desmin, PGP9.5, S100 protein, c-kit, and CD68 in the thoracic esophagus.
1(0,0,0,1) Details
19335429 Chen YF, Chao CM, Liu HN: Cutaneous plasma cell granuloma: report of a case with novel histologic and immunohistochemical findings. Int J Dermatol. 2009 Apr;48(4):409-11.


Scarce S100-positive cells and even rarer CD1a-positive cells were detected.
1(0,0,0,1) Details
20032423 Angiero F, Sozzi D, Seramondi R, Valente MG: Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features. Anticancer Res. 2009 Nov;29(11):4703-9.


RESULTS: Immunohistochemical analysis showed the tumor cells to be weakly positive for S100, cytokeratin (CK) CK5/6, CK7, CKAE-1/AE-3 and strongly positive for epithelial membrane antigen (EMA) and p63; they were focally positive for calponin and acute lymphoblastic leukemia antigen (CD10).
1(0,0,0,1) Details
19118624 Patro N, Shrivastava M, Tripathi S, Patro IK: S100beta upregulation: a possible mechanism of deltamethrin toxicity and motor coordination deficits. Neurotoxicol Teratol. 2009 May-Jun;31(3):169-76. Epub 2008 Dec 7.

1(0,0,0,1) Details
19398873 Kawasaki Y, Suyama K, Go H, Imamura T, Ushijima Y, Sakai N, Hashimoto K, Hosoya M: Accumulation of macrophages expressing myeloid-related protein 8 associated with the progression of sclerotic changes in children with IgA nephropathy. Tohoku J Exp Med. 2009 May;218(1):49-55.


Myeloid-related protein (MRP) 8 is a calcium-binding protein of the S100 family.
1(0,0,0,1) Details
19614993 Hafezi-Bakhtiari S, Al-Habeeb A, Ghazarian D: Benign mixed tumor of the skin, hypercellular variant: a case report. J Cutan Pathol. 2009 Jul 10.


Immunohistochemical studies revealed positive immunoreactivity for EMA, CEA, CD117, HWMK, LWMK, CK7, Androgen receptor and S100 in the ductal (epithelial) cells and positive immunereactivity for calponin, SMA, CK 5/6 and p63 in the myoepithelial component.
1(0,0,0,1) Details
20055602 Alaggio R, Collini P, Randall L, Barnette P, Smith L, Coffin CM: High Grade Pleomorphic Undifferentiated Sarcomas In Children: A Clinicopathologic Study Of 10 Cases and review of literature. Pediatr Dev Pathol. 2010 Jan 7.


CD68 and desmin were positive in 2 cases each, SMA in 4, S100 in one.
1(0,0,0,1) Details
18306486 Shin DA, Kim SH, Yoon do H, Kim TS: A dumbbell-shaped solitary fibrous tumor of the cervical spinal cord. . Yonsei Med J. 2008 Feb 29;49(1):167-70.


Immunohistochemistry was positive for CD34, CD99, and negative for EMA, SMA, and S100; solitary fibrous tumor (SFT) was confirmed.
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