| Name | metalloproteinase |
|---|---|
| Synonyms | Leukolysin; MMP20; Matrix metalloproteinase 20; MMP25; MMP 25; MMP20A; MMPL 1; MMPL1… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19008723 | Suzuki T, Akasaka Y, Namiki A, Ito K, Ishikawa Y, Yamazaki J, Ishii T: Basic fibroblast growth factor inhibits ventricular remodeling in Dahl salt-sensitive hypertensive rats. J Hypertens. 2008 Dec;26(12):2436-44. To clarify the mechanisms underlying the reduced ventricular remodeling in hypertensive heart diseases caused by bFGF, we examined the degree of interstitial fibrosis associated with alpha-smooth muscle actin expression and matrix metalloproteinase activity in hypertensive heart diseases. |
1(0,0,0,1) | Details |
| 18490073 | Schwettmann L, Wehmeier M, Jokovic D, Aleksandrova K, Brand K, Manns MP, Lichtinghagen R, Bahr MJ: Hepatic expression of A disintegrin and metalloproteinase (ADAM) and ADAMs with thrombospondin motives (ADAM-TS) enzymes in patients with chronic liver diseases. J Hepatol. 2008 Aug;49(2):243-50. Epub 2008 Apr 24. |
1(0,0,0,1) | Details |
| 19192169 | Li YL, Wu J, Wei D, Zhang DW, Feng H, Chen ZN, Bian H: Newcastle disease virus represses the activation of human hepatic stellate cells and reverses the development of hepatic fibrosis in mice. Liver Int. 2009 Apr;29(4):593-602. Epub 2009 Jan 28. RESULTS: Tumour-CM and transforming growth factor-beta1 (TGF-beta1) could promote the proliferation and activation of LX-2 cells, indicated by the enhanced expression of alpha-SMA, collagen I, tissue inhibitor of metalloproteinase (TIMP)-1 and TGF-beta1. |
1(0,0,0,1) | Details |
| 17922224 | Wu LM, Wu XX, Sun Y, Kong XW, Zhang YH, Xu Q: A novel synthetic oleanolic acid derivative (CPU-II2) attenuates liver fibrosis in mice through regulating the function of hepatic stellate cells. J Biomed Sci. 2008 Mar;15(2):251-9. Epub 2007 Oct 6. CPU-II2 also attenuated the mRNA expression of alpha-smooth muscle actin (alpha-SMA) and tissue inhibitor of metalloproteinase type 1 (TIMP-1) induced by CCl4 in mice and reduced both mRNA and protein levels of alpha-SMA in HSC-T6 cells. |
1(0,0,0,1) | Details |
| 20034937 | Schweitzer M, Mitmaker B, Obrand D, Sheiner N, Abraham C, Dostanic S, Meilleur M, Sugahara T, Chalifour LE: modulates matrix metalloproteinase expression, activity, and signaling in abdominal aortic aneurysms. Vasc Endovascular Surg. 2010 Feb;44(2):116-22. Epub 2009 Dec 23. Matrix metalloproteinase 1, MMP2, MMP3, MMP9, Tissue Inhibitor of Metalloproteinase (TIMP2), TIMP3, TIMP4, or total Sma Mothers Against Decapentaplegia (SMAD2) expression did not differ with treatment. |
1(0,0,0,1) | Details |
| 19376089 | Szuster-Ciesielska A, Plewka K, Daniluk J, Kandefer-Szerszen M: supplementation attenuates - and -induced liver stellate cell activation by inhibiting reactive species (ROS) production and by influencing intracellular signaling. Biochem Pharmacol. 2009 Aug 1;78(3):301-14. Epub 2009 Apr 17. METHODS: Assessed was the influence of preincubation of rat HSCs with 30 microM ZnCl2 on - (in the presence of 4-methyl pyrazole (4-MP)) or -induced toxicity, apoptosis, migration, expression of smooth muscle alpha-actin (alpha-SMA) and procollagen I, release of reactive species (ROS), tumor necrosis factor-alpha (TNF-alpha), tumor growth factor-beta1 (TGF-beta1), metalloproteinase-2 (MMP-2) and tissue inhibitors of metalloproteinases (TIMPs) production. |
1(0,0,0,1) | Details |
| 20092986 | Kobayashi H, Tanaka Y, Asagiri K, Asakawa T, Tanikawa K, Kage M, Yagi M: The antioxidant effect of green ameliorates experimental liver injury. Phytomedicine. 2010 Mar;17(3-4):197-202. Epub 2010 Jan 25. We also evaluated the levels of activator protein-1 m-RNA (AP-1 m-RNA) and tissue inhibitor metalloproteinase-1 m-RNA (TIMP-1 m-RNA) by Real Time PCR. |
1(0,0,0,1) | Details |
| 17724219 | Lee H, O'Meara SJ, O'Brien C, Kane R: The role of gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4291-9. Zymography was performed for matrix metalloproteinase (MMP) activity. |
1(0,0,0,1) | Details |
| 20177740 | Deng B, Yang X, Liu J, He F, Zhu Z, Zhang C: Focal adhesion kinase mediates TGF-beta1-induced renal tubular epithelial-to-mesenchymal transition in vitro. Mol Cell Biochem. 2010 Feb 23. The expression of FAK, alpha-smooth muscle actin (alpha-SMA),E-cadherin, Akt, matrix metallopeptidase-9 (MMP-9),tissue inhibitor of metalloproteinase-1 (TIMP-1), and collagen IV were detected by RT-PCR, Western blot and immunofluorescence methods, respectively. |
1(0,0,0,1) | Details |
| 19947919 | Paduch R, Kandefer-Szerszen M, Szuster-Ciesielska A, Plewka K: Transforming growth factor-beta1 modulates metalloproteinase-2 and -9, RhoA and alpha-smooth muscle actin expression in colon adenocarcinoma cells. Cell Biol Int. 2010 Jan 25;34(2):213-23. |
1(0,0,0,1) | Details |
| 20062961 | Vercelino R, Crespo I, de Souza GF, Cuevas MJ, de Oliveira MG, Marroni NP, Gonzalez-Gallego J, Tunon MJ: S-nitroso- attenuates liver fibrosis in cirrhotic rats. J Mol Med. 2010 Apr;88(4):401-11. Epub 2010 Jan 9. SNAC down-regulated expression of collagen 1 alpha, alpha-SMA, tumor necrosis factor-alpha, tumor growth factor-beta, metalloproteinase-2, metalloproteinase inhibitor 1, platelet-derived growth factor (PDGF), and PDGF receptor in CBDL rats. |
1(0,0,0,1) | Details |
| 20349720 | Wang L, Tao Y, Li S, Chen G, Liu C: [Effects of salvianolic acid B on lipid peroxidation and metalloproteinase-2 activity in fibrotic liver in rat]. Zhongguo Zhong Yao Za Zhi. 2010 Jan;35(1):71-5. |
4(0,0,0,4) | Details |
| 20358000 | Park SY, Shin HW, Lee KB, Lee MJ, Jang JJ: Differential expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in thioacetamide-induced chronic liver injury. J Korean Med Sci. 2010 Apr;25(4):570-6. Epub 2010 Mar 19. |
2(0,0,0,2) | Details |
| 18939363 | Garncarczyk A, Jurzak M, Gojniczek K: [Characteristic of the endogenous peptides--endothelins and their role in the connective tissue fibrosis]. Wiad Lek. 2008;61(4-6):126-34. The dual regulatory role of ET-1 consist on stimulation of collagen I and III synthesis and simultaneously on inhibition of MMP-1 expression through inhibition of tissue inhibitors of metalloproteinase: TIMP-1 and TIMP-3. |
1(0,0,0,1) | Details |
| 18929613 | Shyu MH, Kao TC, Yen GC: Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl (4) via inhibition of hepatic stellate cells activation. Food Chem Toxicol. 2008 Dec;46(12):3707-13. Epub 2008 Sep 26. Oral administration of EHT reduced the levels of alpha-smooth muscle actin (alpha-SMA) and the activity of metalloproteinases (MMPs) in rats injured by treatment with CCl (4). |
1(0,0,0,1) | Details |
| 19966107 | Attia E, Brown H, Henshaw R, George S, Hannafin JA: Patterns of Gene Expression in a Rabbit Partial Anterior Cruciate Ligament Transection Model: The Potential Role of Mechanical Forces. Am J Sports Med. 2009 Dec 4. HYPOTHESES: (1) Stress deprivation in the surgically transected ACL will increase matrix metalloproteinase (MMP) and alpha smooth muscle actin (alpha-SMA) expression. (2) Stress deprivation will decrease collagen expression. (3) The transected anteromedial bundle of the ACL will demonstrate a pattern of gene expression similar to the completely transected ACL, while gene expression profiles in the intact posterolateral bundle will be similar to the sham-operated controls. |
1(0,0,0,1) | Details |
| 19934446 | Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S: Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. Am J Physiol Renal Physiol. 2009 Dec;297(6):F1510-7. The present study was performed to examine the mechanisms of PF in view of the plasminogen activator (PA)/plasmin/matrix metalloproteinase (MMP) cascade. |
1(0,0,0,1) | Details |