Protein Information

Name FSHbeta
Synonyms FSH B; FSH beta; FSHB; FSHbeta; Follicle stimulating hormone beta subunit; Follitropin beta chain; Follitropin subunit beta; Follitropin subunit beta precursor…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19324968 Lamba P, Fortin J, Tran S, Wang Y, Bernard DJ: A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone beta subunit transcription. Mol Endocrinol. 2009 Jul;23(7):1001-13. Epub 2009 Mar 26.

Activins directly stimulate murine FSHbeta (Fshb) subunit gene transcription through a consensus 8-bp Sma- and Mad-related protein-binding element (SBE) in the proximal promoter.
33(0,1,1,3) Details
20233786 Corpuz PS, Lindaman LL, Mellon PL, Coss D: FoxL2 Is Required for Activin Induction of the Mouse and Human Follicle-Stimulating Hormone {beta}-Subunit Genes. Mol Endocrinol. 2010 Mar 16.

We identify FoxL2 as a critical component in activin induction of FSHbeta, both for the mouse gene, induction of which is Sma- and Mad-related protein (Smad) dependent, and for the human gene that is Smad independent.
9(0,0,1,4) Details