| Name | integrins |
|---|---|
| Synonyms | Alpha 11 precursor; HsT18964; ITGA11; Integrin; Integrin alpha 11; Integrin alpha 11 precursor; MSTP018; HsT18964s… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19516006 | Bystrom B, Carracedo S, Behndig A, Gullberg D, Pedrosa-Domellof F: Alpha11 integrin in the human cornea: importance in development and disease. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5044-53. Epub 2009 Jun 10. |
8(0,0,0,8) | Details |
| 18037995 | Hu K, Wu C, Mars WM, Liu Y: Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling. J Clin Invest. 2007 Dec;117(12):3821-32. |
6(0,0,0,6) | Details |
| 19538194 | El Kahi CG, Atiyeh BS, Abdallah Hajj Hussein I, Jurjus R, Dibo SA, Jurjus A, Jurjus A: Modulation of wound contracture alpha-smooth muscle actin and multispecific vitronectin receptor integrin alphavbeta3 in the rabbit's experimental model. Int Wound J. 2009 Jun;6(3):214-24. |
3(0,0,0,3) | Details |
| 19230171 | Stangou M, Alexopoulos E, Pantzaki A, Leonstini M, Memmos D: C5b-9 glomerular deposition and tubular alpha3beta1-integrin expression are implicated in the development of chronic lesions and predict renal function outcome in immunoglobulin A nephropathy. Scand J Urol Nephrol. 2008;42(4):373-80. |
3(0,0,0,3) | Details |
| 18609274 | Stangou M, Alexopoulos E, Pantzaki A, Leonstini M, Memmos D: C5b-9 glomerular deposition and tubular alpha (3) beta (1)-integrin expression are implicated in the development of chronic lesions and predict renal function outcome in immunoglobulin A nephropathy. Scand J Urol Nephrol. 2008 Feb 21:1-8. |
3(0,0,0,3) | Details |
| 20089260 | Campbell MT, Hile KL, Zhang H, Asanuma H, Vanderbrink BA, Rink RR, Meldrum KK: Toll-Like Receptor 4: A Novel Signaling Pathway During Renal Fibrogenesis. J Surg Res. 2009 Oct 23. The kidneys were harvested and tissues were analyzed for TLR4 expression (Western blot; RTPCR), E-cadherin and alpha smooth muscle actin (alpha-SMA) expression (Western blot), fibroblast accumulation (fibroblast specific protein (FSP-1+) staining), renal fibrosis (collagen I RTPCR, total collagen assay, Masson's trichrome staining), cytokine gene expression (tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 (TGF-beta1) RTPCR), and pSMAD2 and integrin alpha1 expression (Western blot). |
2(0,0,0,2) | Details |
| 19819988 | Chang SF, Chang TK, Peng HH, Yeh YT, Lee DY, Yeh CR, Zhou J, Cheng CK, Chang CA, Chiu JJ: BMP-4 induction of arrest and differentiation of osteoblast-like cells via p21 CIP1 and p27 KIP1 regulation. Mol Endocrinol. 2009 Nov;23(11):1827-38. Epub 2009 Oct 9. Using specific small interfering RNA (siRNA), we found that BMP-4-induced G (0)/G (1) arrest, and p21 (CIP1) and p27 (KIP1) expressions were mediated by BMP receptor type IA (BMPRIA)-specific Sma- and Mad-related protein (Smad) 1/5. Pretreatment of MG63 cells with Arg-Gly-Asp-Ser, which blocks the cell-extracellular matrix interaction, or transfection with beta (3) integrin-specific siRNA inhibited BMP-4-induced ERK and Smad1/5 phosphorylations. |
2(0,0,0,2) | Details |
| 19862337 | Barbaro V, Ferrari S, Fasolo A, Ponzin D, Di Iorio E: Reconstruction of a human hemicornea through natural scaffolds compatible with the growth of corneal epithelial stem cells and stromal keratocytes. Mol Vis. 2009 Oct 17;15:2084-93. The effects of the scaffold on the preservation of stemness and/or induction of differentiation pathways were investigated through analysis of a variety of markers, including p63 and DeltaNp63alpha for stemness, 14-3-3sigma for early differentiation, keratins 3, 14, 12, and 19 to determine cell phenotype, and alpha6, beta1, and beta4 integrins to evaluate interactions with the stroma. |
2(0,0,0,2) | Details |
| 18291634 | Kennedy L, Shi-Wen X, Carter DE, Abraham DJ, Leask A: Fibroblast adhesion results in the induction of a matrix remodeling gene expression program. Matrix Biol. 2008 May;27(4):274-81. Epub 2008 Jan 26. FAK signals downstream of integrin-mediates attachment of fibroblasts to extracellular matrix. |
1(0,0,0,1) | Details |
| 20071339 | Chan MW, Chaudary F, Lee W, Copeland JW, McCulloch CA: Force-induced myofibroblast differentiation through collagen receptors is dependent on mammalian diaphanous (mDia). J Biol Chem. 2010 Mar 19;285(12):9273-81. Epub 2010 Jan 13. In cells treated with siRNA to knockdown mDia and then subjected to tensile force using collagen-coated beads attached to beta1 integrins, actin assembly was inhibited at bead contact sites. |
1(0,0,0,1) | Details |
| 18317806 | Maeda T, Hashitani S, Zushi Y, Segawa E, Tanaka N, Sakurai K, Urade M: Establishment of a nude mouse transplantable model of a human malignant fibrous histiocytoma of the mandible with high metastatic potential to the lung. J Cancer Res Clin Oncol. 2008 Sep;134(9):1005-11. Epub 2008 Mar 4. In MFH-NC, the expressions of MMP7, MMP9, MT1-MMP, CXCR4, COX-2 and integrin alpha4 were up-regulated, while those of MMP2 and TIMP1 were down-regulated. |
1(0,0,0,1) | Details |
| 19519177 | He Z, Zhu Y, Jiang H: Toll-like receptor 4 mediates lipopolysaccharide-induced collagen secretion by phosphoinositide3-kinase-Akt pathway in fibroblasts during acute lung injury. J Recept Signal Transduct Res. 2009;29(2):119-25. The activation of TLR4 stimulated by LPS could also up-regulate the expression of integrin beta1 and TLR4 in mouse lung fibroblast, which could accelerate ALI and pulmonary interstitial fibrosis processes. |
1(0,0,0,1) | Details |
| 18085506 | Brune T, Borel A, Gilbert TW, Franceschi JP, Badylak SF, Sommer P: In vitro comparison of human fibroblasts from intact and ruptured ACL for use in tissue engineering. Eur Cell Mater. 2007 Dec 17;14:78-90; discussion 90-1. Despite these differences in the cell source, both cell populations behaved similarly when seeded on an SIS-ECM scaffold, with similar cell morphology, connective tissue organization and composition, SMA and integrin expression. |
1(0,0,0,1) | Details |
| 20038548 | Dalla Costa AP, Clemente CF, Carvalho HF, Carvalheira JB, Nadruz W Jr, Franchini KG: FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex. Cardiovasc Res. 2010 Jan 22. Treatment with the integrin inhibitor RGD peptide impaired FAK phosphorylation and increased apoptosis (TUNEL) in non-stretched and stretched NF-P3/80, whereas FAK silencing induced by small interfering RNA modestly enhanced apoptosis only in stretched cells. |
1(0,0,0,1) | Details |
| 17849463 | Tilki D, Kilic N, Sevinc S, Zywietz F, Stief CG, Ergun S: Zone-specific remodeling of tumor blood vessels affects tumor growth. Cancer. 2007 Nov 15;110(10):2347-62. Immunostaining for alpha (v) beta (3)-integrin was strongest in small vessels of TMZ, whereas large vessels of TIZ and TCZ were almost negative. |
1(0,0,0,1) | Details |
| 19596799 | Chan MW, Arora PD, Bozavikov P, McCulloch CA: FAK, PIP5KIgamma and gelsolin cooperatively mediate force-induced expression of alpha-smooth muscle actin. J Cell Sci. 2009 Aug 1;122(Pt 15):2769-81. Epub 2009 Jul 13. We subjected NIH3T3 cells to tensile forces (0.65 pN/mum (2)) by using collagen-coated beads attached to integrins. |
1(0,0,0,1) | Details |
| 20235832 | Ayala P, Lopez JI, Desai T: Microtopographical cues in 3D Attenuate Fibrotic Phenotype and Extracellular Matrix Deposition: Implications for Tissue Regeneration. Tissue Eng Part A. 2010 Mar 17. In addition, the contractility marker alpha smooth muscle actin (alpha-SMA) and adhesion molecule integrin alpha3 were also significantly down-regulated. |
1(0,0,0,1) | Details |
| 17718418 | Wang W, Shi YJ, Zhang L, Li Q, Qiu J, Tu ZD, Ye F, Bu H: [Effect of synthesized polypeptide (P16) on inhibiting cell transdifferentiation and fibrosis induced by connective tissue growth factor]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jul;38(4):590-4. OBJECTIVE: To explore the possibility of a CTGF originated hexadeca-peptide (named P16) to compete with the CTGF in binding integrin avP3 on rat tubular epithelial cells (NRK-52E) and inhibit the transdifferentiation and myofibroblasts of NRK-52E cells induced by CTGF. |
1(0,0,0,1) | Details |
| 19652365 | Scotton CJ, Krupiczojc MA, Konigshoff M, Mercer PF, Lee YC, Kaminski N, Morser J, Post JM, Maher TM, Nicholson AG, Moffatt JD, Laurent GJ, Derian CK, Eickelberg O, Chambers RC: Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest. 2009 Sep;119(9):2550-63. doi: 10.1172/JCI33288. Epub 2009 Aug 3. FXa was a potent inducer of the myofibroblast differentiation program in cultured primary human adult lung fibroblasts via TGF-beta activation that was mediated by proteinase-activated receptor-1 (PAR1) and integrin alphavbeta5. |
1(0,0,0,1) | Details |
| 18235011 | Dawes LJ, Eldred JA, Anderson IK, Sleeman M, Reddan JR, Duncan G, Wormstone IM: TGF beta-induced contraction is not promoted by fibronectin-fibronectin receptor interaction, or alpha SMA expression. Invest Ophthalmol Vis Sci. 2008 Feb;49(2):650-61. RESULTS: Real-time PCR analysis showed 10 ng/mL TGF-beta1 or -beta2 significantly increased expression of alphaSMA, fibronectin, and alpha5beta1 integrin (fibronectin receptor components) in FHL 124 cells and human lens epithelia. |
1(0,0,0,1) | Details |