Protein Information

Name CK7
Synonyms CK 7; CK7; Cytokeratin 7; K2C7; K7; KRT 7; KRT7; Keratin 7…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17650214 Rizkalla H, Toner M: Necrotizing sialometaplasia versus invasive carcinoma of the head and neck: the use of myoepithelial markers and keratin subtypes as an adjunct to diagnosis. Histopathology. 2007 Aug;51(2):184-9.


METHODS AND RESULTS: Thirteen cases with the histological changes of NSM, eight SCCs and eight MECs were examined with the following immunohistochemical markers: calponin, S100, smooth muscle actin (SMA), p63, CK7, CK5, CK6 and CAM5.2.
3(0,0,0,3) Details
18847449 Kobayashi Y, Nakanishi Y, Taniguchi H, Sekine S, Igaki H, Tachimori Y, Kato H, Matsubara H, Okazumi S, Shimoda T: Histological diversity in basaloid squamous cell carcinoma of the esophagus. Dis Esophagus. 2009;22(3):231-8. Epub 2008 Oct 10.


Immunoreactivity for CK7, CK14, and SMA was seen in 10.5, 86.8, and 18.4% of SN; 30.8, 97.4, and 38.5% of MT; 54.5, 100.0, and 54.5% of DD; 7.7, 76.9, and 23.1% of CP; and 6.1, 97.0, and 0.0% of SCC, respectively.
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20128962 DU JX, Qiu BF, Liu P, Sun MY, Chen GF, Liu J: [Huangqi decoction inhibits cholangiocyte proliferation and transdifferentiation in cholestatic liver fibrosis induced by BDL in rats.]. Zhonghua Gan Zang Bing Za Zhi. 2010 Jan;18(1):13-8. doi: 10.3760/cma.j.issn.1007-3418.2010.01.004.


In addition, Hyp content of liver tissue and protein expression of CK 7 and a-SMA were significantly increased.
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19184024 Bocker W, Hungermann D, Decker T: [Anatomy of the breast] . Pathologe. 2009 Feb;30(1):6-12.


Diagnostically important cytokeratins of normal breast epithelium and its proliferative epithelial processes include luminal cytokeratins (CK7, CK8 and CK18) as markers of glandular differentiation and basal cytokeratins (CK5, CK14 and CK17) as markers of progenitor cells and early cells of the glandular and myoepithelial differentiation pathway.
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18841827 Di Blasi A, Ferrara G, Antinolfi G, Dalena AM, Antinolfi F: [Clear cell adenomyoepithelioma of the ceruminous gland] . Pathologica. 2008 Jun;100(3):192-6.


By immunohistochemistry, ductal structures were reactive for CK pan, CK7, CK18, CK19, EMA and GCDFP-15.
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19952797 Liu ZJ, Zhang LJ, Zhao Q, Li QW, Wang EB, Ji SJ, Shu H: Pediatric synovial sarcoma of the sacrum: a case report. J Pediatr Orthop B. 2010 Mar;19(2):207-10.


CK, CK7, CK1, CK3, CK8, CK19, Bcl-2, E-cadherin, ki-67, P53, SMA, CD99, CD56, S-100, vimentin, and epithelial membrane antigen were positive.
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18442419 Markopoulos C, Mantas D, Philipidis T, Kouskos E, Antonopoulou Z, Hatzinikolaou M, Gogas H: Glycogen-rich clear cell carcinoma of the breast. . World J Surg Oncol. 2008 Apr 29;6:44.


Diagnosis of clear cell carcinoma was based on certain histological characteristics of the tumour and immunohistochemical analysis (PAS staining, keratins AE1/AE3, EMA, cytokeratin 7, cytokeratin 20, melanosomes, vimentin, Chromogranin, Synaptophysin, S-100, SMA).
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19614993 Hafezi-Bakhtiari S, Al-Habeeb A, Ghazarian D: Benign mixed tumor of the skin, hypercellular variant: a case report. J Cutan Pathol. 2009 Jul 10.


Immunohistochemical studies revealed positive immunoreactivity for EMA, CEA, CD117, HWMK, LWMK, CK7, Androgen receptor and S100 in the ductal (epithelial) cells and positive immunereactivity for calponin, SMA, CK 5/6 and p63 in the myoepithelial component.
1(0,0,0,1) Details
18085381 Fernandez-Flores A, Pol A, Juanes F, Crespo LG: Immunohistochemical phenotype of cutaneous cribriform carcinoma with a panel of 15 antibodies. Med Mol Morphol. 2007 Dec;40(4):212-7. Epub 2007 Dec 21.


The pattern of cytokeratins expressed by our case was positive for AE1-AE3, CAM 5.2, and CK7, without any expression for CK20.
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20032423 Angiero F, Sozzi D, Seramondi R, Valente MG: Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features. Anticancer Res. 2009 Nov;29(11):4703-9.


RESULTS: Immunohistochemical analysis showed the tumor cells to be weakly positive for S100, cytokeratin (CK) CK5/6, CK7, CKAE-1/AE-3 and strongly positive for epithelial membrane antigen (EMA) and p63; they were focally positive for calponin and acute lymphoblastic leukemia antigen (CD10).
1(0,0,0,1) Details
20159698 He Y, Chen BL, Yang RP, Ren M, Zeng ZR: [Comparison of the pathogenesis of liver fibrosis induced by pig serum exposure and bile duct ligation in rats.]. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Feb;30(2):270-4.


The Knodell score was used to evaluate the histological changes in the liver, and immunohistochemistry was performed using anti-SMA, anti-ED1, anti-CK7, and anti-CD45 antibodies.
1(0,0,0,1) Details
18039893 Mekonnen GA, Ijzer J, Nederbragt H: Tenascin-C in chronic canine hepatitis: immunohistochemical localization and correlation with necro-inflammatory activity, fibrotic stage, and expression of alpha-smooth muscle actin, cytokeratin 7, and CD3+ cells. Vet Pathol. 2007 Nov;44(6):803-13.

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18564284 Missall TA, Burkemper NM, Jensen SL, Hurley MY: Immunohistochemical differentiation of four benign eccrine tumors. J Cutan Pathol. 2009 Feb;36(2):190-6. Epub 2008 Jun 17.


METHODS: Ten examples each of normal eccrine structures and of four benign eccrine tumors are analyzed with antibodies to cytokeratin (CK) 7, CD34, CK6, CK10, smooth muscle actin (SMA) and CD10.
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