| Name | SMAD4 |
|---|---|
| Synonyms | DPC 4; DPC4; Deletion target in pancreatic carcinoma 4; JIP; MADH 4; MADH4; Mothers against DPP homolog 4; Mothers against decapentaplegic homolog 4… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19329758 | Derks S, Bosch LJ, Niessen HE, Moerkerk PT, van den Bosch SM, Carvalho B, Mongera S, Voncken JW, Meijer GA, de Bruine AP, Herman JG, van Engeland M: Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21. Carcinogenesis. 2009 Jun;30(6):1041-8. Epub 2009 Mar 27. Several candidate TSGs, among which methyl-CpG-binding domain protein 1 (MBD1), CpG-binding protein CXXC1, Sma- and Mad-related protein 4 (SMAD4), deleted in colon cancer (DCC) and methyl-CpG-binding domain protein 2 (MBD2) are closely linked on a 4-Mb DNA region on chromosome18q21. |
34(0,1,1,4) | Details |
| 17977791 | Bommireddy R, Doetschman T: TGFbeta1 and Treg cells: alliance for tolerance. Trends Mol Med. 2007 Nov;13(11):492-501. Epub 2007 Oct 30. TGFbeta1 prevents abnormal T-cell activation through the modulation of Ca2+-calcineurin signaling in a Caenorhabditis elegans Sma and Drosophila Mad proteins (SMAD) 3 and SMAD4-independent manner; however, in Treg cells, its effects are mediated, at least in part, through SMAD signaling. |
31(0,1,1,1) | Details |
| 19444386 | Cao X, Li X, Hu J, Bao Y: peroxide-induced cellular apoptosis is mediated by TGF-beta2 signaling pathway in cultured human lens epithelial cells. Int Ophthalmol. 2009 May 12. The objective of this study was to investigate the signaling characteristics of transforming growth factor-beta2 (TGF-beta2) and the Smads (Caenorhabditis elegans, Sma; Drosophila mothers against dpp, Mad) signal pathway of cellular apoptosis induced by peroxide with human lens epithelial cells (HLECs). Smad-4 localization was observed by immunocytochemistry. |
3(0,0,0,3) | Details |
| 18171523 | Li T, Leng XS, Zhu JY, Guo YT, Wei YH: [Effect of protein kinase C/transforming growth factor beta 1 pathway on activation of hepatic stellate cells]. Zhonghua Gan Zang Bing Za Zhi. 2007 Dec;15(12):902-5. Western blot and RT-PCR were used to detect the expression of TGF beta1, Smad 4, collagen type I, III and alpha-smooth muscle actin (alpha-SMA) at the 24 h point. |
2(0,0,0,2) | Details |