Protein Information

Name a collagen
Synonyms A collagen; Alpha 1 type XIII collagen isoform 1; Alpha 1 type XIII collagen; Alpha 2 type IV collagen; B collagen; C collagen; COL13A1; COL4A2…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17941111 Henderson JA, He X, Jabbari E: Concurrent differentiation of marrow stromal cells to osteogenic and vasculogenic lineages. Macromol Biosci. 2008 Jun 11;8(6):499-507.


In our in vitro study, concurrent differentiation of BMS cells, a heterogeneous cell population with multilineage differentiation potential, to osteogenic and vascular lineages demonstrated that the substrates (three-dimensional (3-D), collagen type I, aligned fibrils) had a profound effect on guiding the differentiation pathway of BMS cells.
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18683053 Roby T, Olsen S, Nagatomi J: Effect of sustained tension on bladder smooth muscle cells in three-dimensional culture. Ann Biomed Eng. 2008 Oct;36(10):1744-51. Epub 2008 Aug 6.


Using a custom-made device, rat bladder SMCs were cultured in three-dimensional (3-D) collagen gels and exposed to sustained tension.
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19877031 Bogatkevich GS, Ludwicka-Bradley A, Silver RM: Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts. Arthritis Rheum. 2009 Nov;60(11):3455-64.


Contractile activity of lung fibroblasts was measured by a collagen gel contraction assay.
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19494199 Morales SA, Mareninov S, Coulam P, Wadehra M, Goodglick L, Braun J, Gordon LK: Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2). Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4949-56. Epub 2009 Jun 3.


Increased EMP2 was also associated with altered distribution of focal adhesions, changes in actin organization, increased alpha-SMA expression, and increased adherence to a collagen-coated surface.
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17718418 Wang W, Shi YJ, Zhang L, Li Q, Qiu J, Tu ZD, Ye F, Bu H: [Effect of synthesized polypeptide (P16) on inhibiting cell transdifferentiation and fibrosis induced by connective tissue growth factor]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jul;38(4):590-4.


In a CTGF and P16 co-culture system, the P16 inhibited the expression of a-SMA, collagen I and IV up-regulated by the CTGF.
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20038332 Wu XR, Wang Q, Wang L, Shi SS, Guo WD: [The effect of urokinase on hepatic fibrogenesis in rats] . Zhonghua Gan Zang Bing Za Zhi. 2009 Dec;17(12):910-4.


The levels of a-SMA, collagen type I, type III, TIMP-1, PAI-1, TGFb1 proteins were (299.27+/-37.36), (210.05+/-27.17), (192.94+/-24.48), (213.70+/-32.21), (204.25+/-17.92), (205.97+/-23.81), respectively, in UK prevention group, which were significantly lower than those [(418.83+/-30.21), (323.77+/-21.53), (302.37+/-31.43), (376.63+/-25.19), (313.53+/-26.67) and (327.42+/-36.75), respectively] in hepatic fibrosis group.
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18705328 Ha MH, Wei L, Rao HY, Liu F, Wang XY, Feng B, Fei R, Chen HS, Cong X: Effect of interferon-gamma on hepatic stellate cells stimulated by acetaldehyde. Hepatogastroenterology. 2008 May-Jun;55(84):1059-65.


RESULTS: IFN-gamma exhibited a dose-dependent inhibitory effect on a-SMA, collagen type I, collagen type III protein expression in HSC (p <0.01); also IFN-gamma implemented a dose-dependent inhibitory effect on TGF-beta1, Smad4 and especially TGFBRI protein expression in HSC (p <0.01).
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