Protein Information

Name Angiopoietin 2
Synonyms AGPT 2; Ang2; AGPT2; ANG 2; ANGPT 2; ANGPT2; Angiopoietin 2; Angiopoietin 2 precursor…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19567053 Li C, Zhang B, Wang ZH, Chen JC, Li B, Wang SX, Chen J, Li CH, Wang W, Song YF: [Significance of a reversal expression of the angiopoietin-1 and 2 in oral squamous cell carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 May;44(5):412-8.


OBJECTIVE: To investigate the significance of Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2) expression in angiogenesis, vessel maturation, progress and prognosis of oral squamous cell carcinoma (OSCC).
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17935226 Tugues S, Fernandez-Varo G, Munoz-Luque J, Ros J, Arroyo V, Rodes J, Friedman SL, Carmeliet P, Jimenez W, Morales-Ruiz M: Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology. 2007 Dec;46(6):1919-26.


Cirrhosis progression was associated with a significant enhancement of vascular density and expression of vascular endothelial growth factor-A, angiopoietin-1, angiopoietin-2, and placental growth factor in cirrhotic livers.
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18316579 Zhou Q, Guo P, Gallo JM: Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide. Clin Cancer Res. 2008 Mar 1;14(5):1540-9.


Furthermore, both sunitinib-treated groups maintained the molecular balance between angiopoietins Ang-1 and Ang-2, suggesting a critical role of angiopoietins in vascular normalization.
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