Protein Information

Name Notch 1
Synonyms NOTCH1; Neurogenic locus notch homolog protein 1; Neurogenic locus notch homolog protein 1 precursor; Notch (Drosophila) homolog 1 (translocation associated); Notch 1; TAN 1; TAN1; Translocation associated notch homolog…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
20348013 Saad S, Stanners SR, Yong R, Tang O, Pollock CA: NOTCH MEDIATED EPITHELIAL TO MESENCHYMAL TRANSFORMATION IS ASSOCIATED WITH INCREASED EXPRESSION OF THE SNAIL TRANSCRIPTION FACTOR. Int J Biochem Cell Biol. 2010 Mar 25.


The expressions of Notch 1, Snail, E-cadherin and alpha-smooth muscle actin (alpha-SMA) were determined by Western blot.
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18239137 Tang Y, Urs S, Liaw L: Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. Circ Res. 2008 Mar 28;102(6):661-8. Epub 2008 Jan 31.


Using primary human smooth muscle cells, we show that expression of the constitutive active ICD of human Notch1, Notch2, or Notch4 receptors increase SMA levels.
1(0,0,0,1) Details