Protein Information

Name osteopontin
Synonyms BNSP; Spp1; BSPI; Bone sialoprotein; Bone sialoprotein 1; ETA 1; ETA1; Early T lymphocyte activation 1…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18067644 Tokairin T, Nishikawa Y, Watanabe H, Doi Y, Omori Y, Yoshioka T, Yamamoto Y, Yoshida M, Nishimura T, Li Q, Arai H, Ishida A, Takada G, Enomoto K: Osteopontin expression in the liver with severe perisinusoidal fibrosis: autopsy case of Down syndrome with transient myeloproliferative disorder. Pathol Int. 2008 Jan;58(1):64-8.

2(0,0,0,2) Details
18363643 Wang N, Yang J, Yu X, Hu J, Xing C, Ju X, Shen X, Qian J, Zhao X, Wang X: Radial artery calcification in end-stage renal disease patients is associated with deposition of osteopontin and diminished expression of alpha-smooth muscle actin. Nephrology. 2008 Oct;13(5):367-75. Epub 2008 Mar 17.

2(0,0,0,2) Details
19032867 Liu P, Chen DF, Wang J, Ai ZL, Fan LL, Wang XM, Yan LL: [The expression and significance of osteopontin in the development of nonalcoholic fatty liver fibrosis in rats]. Zhonghua Gan Zang Bing Za Zhi. 2008 Nov;16(11):831-4.

2(0,0,0,2) Details
19816704 Karaoz E, Dogan BN, Aksoy A, Gacar G, Akyuz S, Ayhan S, Genc ZS, Yuruker S, Duruksu G, Demircan PC, Sariboyaci AE: Isolation and in vitro characterisation of dental pulp stem cells from natal teeth. Histochem Cell Biol. 2010 Jan;133(1):95-112. Epub 2009 Oct 9.


Ultrastructural characteristics of hNDP-SCs showed more developed and metabolically active cells. hNDP-SCs and hBM-MSCs expressed some adipogenic (leptin, adipophilin and PPARgamma), myogenic (desmin, myogenin, myosinIIa, and alpha-SMA), neurogenic (gamma-enolase, MAP2a,b, c-fos, nestin, NF-H, NF-L, GFAP and betaIII tubulin), osteogenic (osteonectin, osteocalcin, osteopontin, Runx-2, and type I collagen) and chondrogenic (type II collagen, SOX9) markers without any stimulation towards differentiation under basal conditions.
1(0,0,0,1) Details
17570339 Zhao C, Hosoya A, Kurita H, Hu T, Hiraga T, Ninomiya T, Yoshiba K, Yoshiba N, Takahashi M, Kurashina K, Ozawa H, Nakamura H: Immunohistochemical study of hard tissue formation in the rat pulp cavity after tooth replantation. Arch Oral Biol. 2007 Oct;52(10):945-53. Epub 2007 Jun 13.


Immunoreactivity for osteopontin (OPN) and bone sialoprotein (BSP) was strong in the bone-like tissue, but weak in the dentin-like tissue.
1(0,0,0,1) Details
19223006 Nishikimi T, Inaba-Iemura C, Ishimura K, Tadokoro K, Koshikawa S, Ishikawa K, Akimoto K, Hattori Y, Kasai K, Minamino N, Maeda N, Matsuoka H: Natriuretic peptide/natriuretic peptide receptor-A (NPR-A) system has inhibitory effects in renal fibrosis in mice. Regul Pept. 2009 Apr 10;154(1-3):44-53. Epub 2009 Feb 15.


In contrast, ANP pre-treatment significantly improved morphological changes with increase of tissue cGMP levels and reduction in the mRNA expression level of TGF-beta, collagen I, collagen III, PAI-1, ICAM-1, osteopontin, MCP-1, renin, and angiotensinogen.
1(0,0,0,1) Details
19688349 Karaoz E, Aksoy A, Ayhan S, Sariboyaci AE, Kaymaz F, Kasap M: Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers. Histochem Cell Biol. 2009 Nov;132(5):533-46. Epub 2009 Aug 14.


Immunohistochemistry and RT-PCR results indicated that BM-MSCs expressed myogenic (desmin, myogenin, myosin IIa, and alpha-SMA), neurogenic (gamma-enolase, MAP2a,b, c-fos, nestin, GFAP and beta III tubulin), and osteogenic (osteonectin, osteocalcin, osteopontin, Runx-2, BMP-2, BMP-4 and type I collagen) markers without stimulation towards differentiation.
1(0,0,0,1) Details