Protein Information

Name hypoxia inducible factor 1alpha
Synonyms ARNT interacting protein; HIF 1 alpha; HIF 1alpha; HIF1 alpha; HIF1A; Hypoxia inducible factor 1 alpha subunit; Hypoxia inducible factor 1 alpha; Hypoxia inducible factor 1alpha…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
20123452 Abedalthagafi M, Rushing EJ, Auerbach A, Desouki MM, Marwaha J, Wang Z, Fanburg-Smith JC: Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1alpha: a histologic and immunohistochemical study of 45 cases. Ann Diagn Pathol. 2010 Feb;14(1):15-22. Epub 2009 Dec 11.

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18586873 Nakashizuka H, Mitsumata M, Okisaka S, Shimada H, Kawamura A, Mori R, Yuzawa M: Clinicopathologic findings in polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4729-37. Epub 2008 Jun 27.


Immunohistochemical studies were also performed to identify CD34, vascular endothelial growth factor (VEGF), CD68, alpha-smooth muscle actin (alpha-SMA) and hypoxia-inducible factor (HIF)-1alpha.
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18050204 Clancy RM, Zheng P, O'Mahony M, Izmirly P, Zavadil J, Gardner L, Buyon JP: Role of hypoxia and cAMP in the transdifferentiation of human fetal cardiac fibroblasts: implications for progression to scarring in autoimmune-associated congenital heart block. Arthritis Rheum. 2007 Dec;56(12):4120-31.


RESULTS: In vivo hypoxic exposure was supported by the prominent intracellular fibroblast expression of hypoxia-inducible factor 1alpha in conduction tissue from 2 fetuses in whom CHB led to death.
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19683567 Xu X, Kherada N, Hong X, Quan C, Zheng L, Wang A, Wold LE, Lippmann M, Chen LC, Rajagopalan S, Sun Q: Diesel exhaust exposure induces angiogenesis. Toxicol Lett. 2009 Dec 1;191(1):57-68. Epub 2009 Aug 14.


In addition, WDE exposure significantly increased mRNA expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1alpha, while decreasing prolylhydroxylase (PHD) 2 expression.
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20232302 Roson MI, Della Penna SL, Cao G, Gorzalczany S, Pandolfo M, Toblli JE, Fernandez BE: Different protective actions of losartan and tempol on the renal inflammatory response to acute sodium overload. J Cell Physiol. 2010 Mar 15.


Ang II, NF-kappaB, hypoxia inducible factor-1alpha (HIF-1alpha), transforming growth factor beta1 (TGF-beta1), smooth muscle actin (alpha-SMA), endothelial nitric oxide synthase (eNOS), and RANTES renal expression was evaluated by immunohistochemistry.
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