Protein Information

Name Secreted protein acidic and rich in cysteine
Synonyms BM 40; Basement membrane protein BM 40; Basement membrane protein 40; ON; Osteonectin; SPARC; SPARC precursor; Secreted protein acidic and rich in cysteine…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18787407 Mantoni TS, Schendel RR, Rodel F, Niedobitek G, Al-Assar O, Masamune A, Brunner TB: Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma. Cancer Biol Ther. 2008 Nov 24;7(11).

11(0,0,0,11) Details
17898292 Gotoh N, Perdue NR, Matsushima H, Sage EH, Yan Q, Clark JI: An in vitro model of posterior capsular opacity: SPARC and TGF-beta2 minimize epithelial-to-mesenchymal transition in lens epithelium. Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4679-87.

5(0,0,0,5) Details
18813945 Wessel C, Westhoff CC, Nowak K, Moll I, Barth PJ: CD34 (+) fibrocytes in melanocytic nevi and malignant melanomas of the skin. Virchows Arch. 2008 Nov;453(5):485-9. Epub 2008 Sep 24.


Secreted protein acidic and rich in cysteine (SPARC) is an important mediator of tumor-associated stromal remodeling.
2(0,0,0,2) Details
19816704 Karaoz E, Dogan BN, Aksoy A, Gacar G, Akyuz S, Ayhan S, Genc ZS, Yuruker S, Duruksu G, Demircan PC, Sariboyaci AE: Isolation and in vitro characterisation of dental pulp stem cells from natal teeth. Histochem Cell Biol. 2010 Jan;133(1):95-112. Epub 2009 Oct 9.


Ultrastructural characteristics of hNDP-SCs showed more developed and metabolically active cells. hNDP-SCs and hBM-MSCs expressed some adipogenic (leptin, adipophilin and PPARgamma), myogenic (desmin, myogenin, myosinIIa, and alpha-SMA), neurogenic (gamma-enolase, MAP2a,b, c-fos, nestin, NF-H, NF-L, GFAP and betaIII tubulin), osteogenic (osteonectin, osteocalcin, osteopontin, Runx-2, and type I collagen) and chondrogenic (type II collagen, SOX9) markers without any stimulation towards differentiation under basal conditions.
1(0,0,0,1) Details
20340130 Vered M, Dayan D, Yahalom R, Dobriyan A, Barshack I, Bello IO, Kantola S, Salo T: Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma. Int J Cancer. 2010 Mar 25.


EMT was studied with syndecan-1, Cadherin-11, fibroblast specific protein (FSP)-1, secreted protein acidic and rich in cysteine (SPARC) and Twist.
1(0,0,0,1) Details
19688349 Karaoz E, Aksoy A, Ayhan S, Sariboyaci AE, Kaymaz F, Kasap M: Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers. Histochem Cell Biol. 2009 Nov;132(5):533-46. Epub 2009 Aug 14.


Immunohistochemistry and RT-PCR results indicated that BM-MSCs expressed myogenic (desmin, myogenin, myosin IIa, and alpha-SMA), neurogenic (gamma-enolase, MAP2a,b, c-fos, nestin, GFAP and beta III tubulin), and osteogenic (osteonectin, osteocalcin, osteopontin, Runx-2, BMP-2, BMP-4 and type I collagen) markers without stimulation towards differentiation.
1(0,0,0,1) Details
17963954 Martinez EF, Araujo VC, Sousa SO, Arana-Chavez VE: TGF-beta1 enhances the expression of alpha-smooth muscle actin in cultured human pulpal fibroblasts: immunochemical and ultrastructural analyses. J Endod. 2007 Nov;33(11):1313-8. Epub 2007 Sep 17.


In addition, the expression of tenascin, osteonectin, and vimentin was also investigated.
1(0,0,0,1) Details