Protein Information

Name hemoglobin (protein family or complex)
Synonyms Hemoglobin; Hemoglobins

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19884328 Ouma C, Keller CC, Davenport GC, Were T, Konah S, Otieno MF, Hittner JB, Vulule JM, Martinson J, Ong'echa JM, Ferrell RE, Perkins DJ: A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia. Infect Immun. 2010 Jan;78(1):453-60. Epub 2009 Nov 2.


To extend these investigations, the relationships between a novel SCGF promoter variant (-539C/T, rs7246355), SMA (hemoglobin [Hb] < 6.0 g/dl), and reduced erythropoietic responses (reticulocyte production index [RPI], <2.0) were investigated with Kenyan children (n = 486) with falciparum malaria from western Kenya.
2(0,0,0,2) Details
19528216 Keller CC, Ouma C, Ouma Y, Awandare GA, Davenport GC, Were T, Hittner JB, Vulule JM, Ong'echa JM, Perkins DJ: Suppression of a novel hematopoietic mediator in children with severe malarial anemia. Infect Immun. 2009 Sep;77(9):3864-71. Epub 2009 Jun 15.


Circulating SCGF also correlated positively with hemoglobin levels (r = 0.241; P = 0.022) and the reticulocyte production index (RPI) (r = 0.280; P = 0.029).
1(0,0,0,1) Details
19030850 Harada T, Miyai I, Suzuki M, Kubota K: Gait capacity affects cortical activation patterns related to speed control in the elderly. Exp Brain Res. 2009 Mar;193(3):445-54. Epub 2008 Nov 22.


Using functional near-infrared spectroscopy, we measured the changes in the cortical oxygenated hemoglobin (oxyHb) while the subjects walked on a treadmill at low, moderate, and high speeds corresponding to 30, 50, and 70% intensity of work load in each subject.
1(0,0,0,1) Details
19002725 Giha HA, Elghazali G, A-Elgadir TM, A-Elbasit IE, Elbashir MI: Severe malaria in an unstable setting: clinical and laboratory correlates of cerebral malaria and severe malarial anemia and a paradigm for a simplified severity scoring. Eur J Clin Microbiol Infect Dis. 2009 Jun;28(6):661-5. Epub 2008 Nov 12.


Hemoglobin (Hb), random blood glucose (RBG), and anti-MSP antibodies were measured.
1(0,0,0,1) Details
20231419 Ogonda LA, Orago AS, Otieno MF, Adhiambo C, Otieno W, Stoute JA: Increased level of CD16/Fc{gamma}RIIIA on CD14+CD16+ monocytes of children with severe Plasmodium falciparum anemia compared to children with cerebral or uncomplicated malaria. Infect Immun. 2010 Mar 15.


Furthermore, there was an inverse correlation between hemoglobin levels and CD16/FcgammaRIIIA expression in children with SMA and their controls.
1(0,0,0,1) Details
18759748 Srisawat N, Manotham K, Eiam-Ong S, Katavetin P, Praditpornsilpa K, Eiam-Ong S: Erythropoietin and its non-erythropoietic derivative: do they ameliorate renal tubulointerstitial injury in ureteral obstruction?. Int J Urol. 2008 Oct;15(11):1011-7. Epub 2008 Aug 26.


The renoprotective effects of EPO and carbamylated-erythropoietin (CEPO), a novel EPO which has a small stimulatory effect on hemoglobin, have never been explored in unilateral ureteral obstruction (UUO), a chronic tubulointerstitial (TI) disease model which is independent of systemic factors.
1(0,0,0,1) Details
18781863 Ouma C, Davenport GC, Awandare GA, Keller CC, Were T, Otieno MF, Vulule JM, Martinson J, Ong'echa JM, Ferrell RE, Perkins DJ: Polymorphic variability in the interleukin (IL)-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1beta production. J Infect Dis. 2008 Oct 15;198(8):1219-26.


Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1beta promoter variants (-31C/T and -511A/G), SMA (hemoglobin [Hb] level <6.0 g/dL), and circulating IL-1beta levels were investigated in children with parasitemia (n= 566) from western Kenya.
1(0,0,0,1) Details
17952494 Vanderhaegen J, Dehing L, Naulaers G, Devlieger H, Al-Olayet Y, Penninckx F, Miserez M: Use of the liver tissue oxygenation index as a noninvasive parameter of intestinal ischemia in rabbits. World J Surg. 2007 Dec;31(12):2359-62.


OBJECTIVE: The tissue oxygenation index (TOI), measured by spatially resolved spectroscopy (SRS), reflects the ratio between oxygenated and deoxygenated tissue hemoglobin.
1(0,0,0,1) Details