Protein Information

Name Tenascin C
Synonyms Cytotactin; GMEM; GP 150 225; Glioma associated extracellular matrix antigen; HXB; Hexabrachion; JI; Myotendinous antigen…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17999372 Nishimura T, Hirata H, Tsujii M, Iida R, Hoki Y, Iino T, Ogawa S, Uchida A: Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages. Histol Histopathol. 2008 Feb;23(2):157-66.


To examine the pathomechanism of entrapment neuropathy associated with diabetes with special emphasis on the roles of mast cells and Tenascin-C using a rat model of Streptozotocin-induced diabetes.
5(0,0,0,5) Details
18039893 Mekonnen GA, Ijzer J, Nederbragt H: Tenascin-C in chronic canine hepatitis: immunohistochemical localization and correlation with necro-inflammatory activity, fibrotic stage, and expression of alpha-smooth muscle actin, cytokeratin 7, and CD3+ cells. Vet Pathol. 2007 Nov;44(6):803-13.

2(0,0,0,2) Details
19324862 Chen J, Guerriero E, Sado Y, SundarRaj N: Rho-mediated regulation of TGF-beta1- and FGF-2-induced activation of corneal stromal keratocytes. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3662-70. Epub 2009 Mar 25.


Whereas Rho inhibition downregulated both TGF-beta1- and FGF-2-induced tenascin-C expression, ROCK inhibition was found to downregulate only TGF-beta1-induced expression.
2(0,0,0,2) Details
20163211 Cheng MT, Liu CL, Chen TH, Lee OK: Comparison of Potentials between Stem Cells Isolated from Human Anterior Cruciate Ligament and Bone Marrow for Ligament Tissue Engineering. Tissue Eng Part A. 2010 Feb 17.


TGF-beta1 treatment significantly increased the expression of type I collagen, type III collagen, fibronectin, and alpha-smooth muscle actin (alpha-SMA) in LSCs, but TGF-beta1 only up-regulated type I collagen and tenascin-c on BMSCs.
1(0,0,0,1) Details
19940066 Pattabiraman PP, Rao PV: Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. Am J Physiol Cell Physiol. 2010 Mar;298(3):C749-63. Epub 2009 Nov 25.


TM cells expressing RhoAV14 exhibited significant increases in fibronectin, tenascin C, laminin, alpha-smooth muscle actin (alpha-SMA) levels, and matrix assembly in association with increased actin stress fibers and myosin light-chain phosphorylation.
1(0,0,0,1) Details
17963954 Martinez EF, Araujo VC, Sousa SO, Arana-Chavez VE: TGF-beta1 enhances the expression of alpha-smooth muscle actin in cultured human pulpal fibroblasts: immunochemical and ultrastructural analyses. J Endod. 2007 Nov;33(11):1313-8. Epub 2007 Sep 17.


In addition, the expression of tenascin, osteonectin, and vimentin was also investigated.
1(0,0,0,1) Details