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Bujak M, Dobaczewski M, Gonzalez-Quesada C, Xia Y, Leucker T, Zymek P, Veeranna V, Tager AM, Luster AD, Frangogiannis NG: Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction. Circ Res. 2009 Nov 6;105(10):973-83. Epub 2009 Sep 24.
IP-10 (-/-) infarcts had more intense infiltration with CD45 (+) leukocytes, Mac-2 (+) macrophages, and alpha-smooth muscle actin (alpha-SMA)(+) myofibroblasts than WT infarcts but exhibited reduced recruitment of the subpopulations of leukocytes, T lymphocytes and alpha-SMA (+) cells that expressed CXCR3, the IP-10 receptor. |
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