Protein Information

Name decorin
Synonyms Bone proteoglycan II; PGs2; CSCD; DCN; DSPG 2; DSPG2; Decorin; Decorin isoform a preproprotein…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19167828 Zhang Z, Garron TM, Li XJ, Liu Y, Zhang X, Li YY, Xu WS: Recombinant human decorin inhibits TGF-beta1-induced contraction of collagen lattice by hypertrophic scar fibroblasts. Burns. 2009 Jun;35(4):527-37. Epub 2009 Jan 23.

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19542195 Osada S, Hamada C, Shimaoka T, Kaneko K, Horikoshi S, Tomino Y: Alterations in proteoglycan components and histopathology of the peritoneum in uraemic and peritoneal dialysis (PD) patients. Nephrol Dial Transplant. 2009 Nov;24(11):3504-12. Epub 2009 Jun 19.


Human peritoneal mesothelial cells synthesize small proteoglycans including decorin.
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17952560 Nakatani T, Honda E, Hayakawa S, Sato M, Satoh K, Kudo M, Munakata H: Effects of decorin on the expression of alpha-smooth muscle actin in a human myofibroblast cell line. Mol Cell Biochem. 2008 Jan;308(1-2):201-7. Epub 2007 Oct 20.

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17868111 Fu SC, Cheuk YC, Chan KM, Hung LK, Wong MW: Is cultured tendon fibroblast a good model to study tendon healing? . J Orthop Res. 2008 Mar;26(3):374-83.


The mRNA expression of COL1A1, COL3A1, decorin, and biglycan, with or without supplementation of 1 ng/mL TGF-beta1, was compared by quantitative real-time RT-PCR.
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18955978 Wang J, Dodd C, Shankowsky HA, Scott PG, Tredget EE: Deep dermal fibroblasts contribute to hypertrophic scarring. Lab Invest. 2008 Dec;88(12):1278-90. Epub 2008 Oct 27.


Interestingly, cells from the deeper layers also produced more of the proteoglycan, versican, but less decorin.
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17963106 Dogru M, Kato N, Matsumoto Y, Tanaka Y, Akabane N, Shimmura S, Tsubota K, Shimazaki J: Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. Curr Eye Res. 2007 Oct;32(10):863-70.


The corneal buttons were processed for histologic examination with hematoxylin and eosin staining and underwent immunohistochemistry stainings for collagen types I, III, IV, V, VI, VIII, fibronectin, laminin, and decorin.
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