| Name | Gemin2 |
|---|---|
| Synonyms | Component of gems 2; SIP1; GEMIN2; Gemin 2; SIP1 delta; SMN interacting protein 1; Survival interacting protein 1; Survival of motor neuron protein interacting protein 1… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18000835 | McWhorter ML, Boon KL, Horan ES, Burghes AH, Beattie CE: The SMN binding protein Gemin2 is not involved in motor axon outgrowth. Dev Neurobiol. 2008 Feb 1;68(2):182-94. To determine whether decreasing other components of the snRNP complex would also cause motor axon defects, we knocked down Gemin2, a SMN binding protein involved in snRNP assembly. |
5(0,0,0,5) | Details |
| 20188701 | Todd AG, Shaw DJ, Morse R, Stebbings H, Young PJ: SMN and the Gemin proteins form sub-complexes that localise to both stationary and dynamic neurite granules. Biochem Biophys Res Commun. 2010 Mar 26;394(1):211-6. Epub 2010 Feb 25. It is known that SMN is present in transport ribonucleoproteins (RNPs) granules that also contain Gemin2 and Gemin3. |
2(0,0,0,2) | Details |
| 19617559 | Bruns AF, van Bergeijk J, Lorbeer C, Nolle A, Jungnickel J, Grothe C, Claus P: Fibroblast growth factor-2 regulates the stability of nuclear bodies. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12747-52. Epub 2009 Jul 17. Down-regulation of Gemin2 by siRNA caused destabilization of SMN-positive nuclear bodies. |
1(0,0,0,1) | Details |
| 19430205 | Singh NN, Shishimorova M, Cao LC, Gangwani L, Singh RN: A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy. RNA Biol. 2009 Jul;6(3):341-50. Epub 2009 Jul 14. We further demonstrate that a single low nanomolar dose of this 8-mer ASO substantially increases the levels of SMN and a host of factors including Gemin 2, Gemin 8, ZPR1, hnRNP Q and Tra2-beta1 known to be down-regulated in SMA. |
1(0,0,0,1) | Details |
| 18675250 | Lorson MA, Dickson AM, Shaw DJ, Todd AG, Young EC, Morse R, Wolstencroft C, Lorson CL, Young PJ: Identification and characterisation of a nuclear localisation signal in the SMN associated protein, Gemin4. Biochem Biophys Res Commun. 2008 Oct 10;375(1):33-7. Epub 2008 Jul 31. Gemin4 is one of the core components of the Gemin-complex, which also contains survival motor neuron (SMN), the seven Gemin proteins (Gemin2-8), and Unrip. |
1(0,0,0,1) | Details |