| Name | beta is |
|---|---|
| Synonyms | "beta I"; Alpha II; Alpha tryptase; Beta I; Lung tryptase; Mast cell protease II; Mast cell tryptase; Pituitary tryptase… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18952846 | Kita T, Hata Y, Arita R, Kawahara S, Miura M, Nakao S, Mochizuki Y, Enaida H, Goto Y, Shimokawa H, Hafezi-Moghadam A, Ishibashi T: Role of TGF-beta in proliferative vitreoretinal diseases and ROCK as a therapeutic target. Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17504-9. Epub 2008 Oct 24. TGF-beta is overexpressed in the vitreous of patients with proliferative vitreoretinal diseases and is also detectable in the contractile membranes. |
2(0,0,0,2) | Details |
| 18988920 | Shukla MN, Rose JL, Ray R, Lathrop KL, Ray A, Ray P: Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad7. Am J Respir Cell Mol Biol. 2009 Jun;40(6):643-53. Epub 2008 Nov 6. Since TGF-beta is known to regulate alpha-SMA expression, the effect of HGF on components of TGF-beta signaling was investigated. |
1(0,0,0,1) | Details |
| 19747910 | Chen H, Yang WW, Wen QT, Xu L, Chen M: TGF-beta-induced fibroblast activation protein expression, fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM. Exp Mol Pathol. 2009 Dec;87(3):189-94. Epub 2009 Sep 10. We discover that TGF-beta is the dominant factor in promoting FAPalpha protein expression. |
1(0,0,0,1) | Details |
| 19011237 | Jobling AI, Gentle A, Metlapally R, McGowan BJ, McBrien NA: Regulation of scleral cell contraction by transforming growth factor-beta and stress: competing roles in myopic eye growth. J Biol Chem. 2009 Jan 23;284(4):2072-9. Epub 2008 Nov 14. These results show that although reduced scleral TGF-beta is a major contributor to the extracellular matrix remodeling in the myopic eye, it is the resulting increase in scleral stress that dominates the competing TGF-beta effect, inducing increased alpha-SMA expression and, hence, producing a larger population of contractile cells in the myopic eye. |
1(0,0,0,1) | Details |
| 18355371 | Nonaka M, Pawankar R, Fukumoto A, Yagi T: Heterogeneous response of nasal and lung fibroblasts to transforming growth factor-beta 1. Clin Exp Allergy. 2008 May;38(5):812-21. Epub 2008 Mar 18. TGF-beta is thought to participate in chronic inflammation and fibrosis. |
1(0,0,0,1) | Details |
| 19286977 | Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Phipps RP, Sime PJ: Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts. Am J Respir Cell Mol Biol. 2009 Dec;41(6):722-30. Epub 2009 Mar 13. Transforming growth factor (TGF)-beta is up-regulated in fibrotic diseases, where it stimulates differentiation of fibroblasts to myofibroblasts and production of excess extracellular matrix. |
1(0,0,0,1) | Details |
| 18423981 | Denys H, Derycke L, Hendrix A, Westbroek W, Gheldof A, Narine K, Pauwels P, Gespach C, Bracke M, De Wever O: Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion. Cancer Lett. 2008 Aug 8;266(2):263-74. We report that TGF-beta is the unique and dominant factor to provide pro-invasive signals to HCT-8/E11 colon cancer cells from TGF-beta-treated human fibroblasts in three-dimensional collagen type I and Matrigel matrices. |
1(0,0,0,1) | Details |
| 20042656 | Tamiya S, Liu L, Kaplan HJ: Loss of cell-cell contact initiates epithelial-mesenchymal transition and proliferation of retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2009 Dec 30. While TGF-beta is thought to be a classic inducer of EMT, it was unable to initiate EMT in RPE cells maintaining cell-cell contact. |
1(0,0,0,1) | Details |
| 20131076 | Liu H, Liu F, Peng Y, Liu Y, Li L, Tu X, Cheng M, Xu X, Chen X, Ling G, Sun L: Role of mast cells, stem cell factor and protease-activated receptor-2 in tubulointerstitial lesions in IgA nephropathy. Inflamm Res. 2010 Feb 4. Monoclonal antibodies to human tryptase, alpha-SMA, and SCF and polyclonal antibody to PAR-2 were used as primary antibodies. |
1(0,0,0,1) | Details |
| 19640259 | Li J, Zhang Z, Wang D, Wang Y, Li Y, Wu G: TGF-beta 1/Smads signaling stimulates renal interstitial fibrosis in experimental AAN. J Recept Signal Transduct Res. 2009;29(5):280-5. Collectively, the involvement in interstitial fibrosis progression of active TGF-beta is highly suggested, via the Smads intracellular signaling pathway. |
1(0,0,0,1) | Details |
| 18832581 | Liu AC, Gotlieb AI: Transforming growth factor-beta regulates in vitro heart valve repair by activated valve interstitial cells. Am J Pathol. 2008 Nov;173(5):1275-85. Epub 2008 Oct 2. Because transforming growth factor-beta (TGF-beta) has been implicated in tissue repair, we tested the hypothesis that TGF-beta is a regulator of VIC activation and associated cell responses that occur during early repair processes. |
1(0,0,0,1) | Details |
| 18235011 | Dawes LJ, Eldred JA, Anderson IK, Sleeman M, Reddan JR, Duncan G, Wormstone IM: TGF beta-induced contraction is not promoted by fibronectin-fibronectin receptor interaction, or alpha SMA expression. Invest Ophthalmol Vis Sci. 2008 Feb;49(2):650-61. PURPOSE: Transforming growth factor (TGF)-beta is a potent inducer of both transdifferentiation and contraction, which are regarded as critical processes that underpin tissue fibrosis. |
1(0,0,0,1) | Details |
| 18813789 | Naumann U, Maass P, Gleske AK, Aulwurm S, Weller M, Eisele G: Glioma gene therapy with soluble transforming growth factor-beta receptors II and III. Int J Oncol. 2008 Oct;33(4):759-65. Transforming growth factor-beta (TGF-beta) is abundantly expressed in malignant gliomas and is crucial for the tumor micromilieu. Binding of TGF-beta leads to the activation of an intracellular signaling cascade and subsequent phosphorylation of Sma and MAD-related proteins (SMAD). |
1(0,0,0,1) | Details |