| Name | Smad 3 |
|---|---|
| Synonyms | HSMAD 3; Mad3; HSMAD3; HSPC193; HsT17436; JV15 2; MADH 3; MADH3… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17889631 | Wang Z, Gao Z, Shi Y, Sun Y, Lin Z, Jiang H, Hou T, Wang Q, Yuan X, Zhu X, Wu H, Jin Y: Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts. Biochem Pharmacol. 2009 Aug 1;78(3):301-14. Epub 2009 Apr 17. In this paper, we examined the function of Sma and Drosophila mothers against decapentaplegic homolog 3 (Smad3), recently characterized as intracellular effector of TGF-beta signalling, in keloid fibroblasts using siRNA. |
81(1,1,1,1) | Details |
| 18802055 | Al-Salleeh F, Petro TM: Promoter analysis reveals critical roles for SMAD-3 and ATF-2 in expression of IL-23 p19 in macrophages. J Plast Reconstr Aesthet Surg. 2007;60(11):1193-9. Epub 2007 Jan 19. We identified potential binding sites for IFN response factor (IRF)-3 (nt -734 to -731), Sma- and Mad-related protein (SMAD)-3 (nt -584 to -581), activating transcription factor (ATF)-2 (nt -571 to -568), IRF-7 (nt -533 to-525), and NF-kappaB (nt -215 to -209) in the murine p19 promoter. |
36(0,1,1,6) | Details |
| 17977791 | Bommireddy R, Doetschman T: TGFbeta1 and Treg cells: alliance for tolerance. Trends Mol Med. 2007 Nov;13(11):492-501. Epub 2007 Oct 30. TGFbeta1 prevents abnormal T-cell activation through the modulation of Ca2+-calcineurin signaling in a Caenorhabditis elegans Sma and Drosophila Mad proteins (SMAD) 3 and SMAD4-independent manner; however, in Treg cells, its effects are mediated, at least in part, through SMAD signaling. |
31(0,1,1,1) | Details |
| 17595316 | Li Q, Graff JM, O'Connor AE, Loveland KL, Matzuk MM: SMAD3 regulates gonadal tumorigenesis. . 1342.e1-7. Epub 2008 Aug 29. Because Sma and Mad-related protein (SMAD) 2 and SMAD3 transduce activin signals in vitro, we attempted to define the role of SMAD3 in gonadal tumorigenesis and the wasting syndrome by generating inhibin alpha and Smad3 double mutant mice. |
11(0,0,1,6) | Details |
| 19026825 | Zhou JH, Jiang YG, Wang RW, Fan SZ, Gong TQ, Tan QY, Ma Z, Zhao YP, Deng B: Prevention of stricture development after corrosive esophageal burn with a modified esophageal stent in dogs. J Thorac Cardiovasc Surg. 2008 Nov;136(5):1336-42 Transforming growth factor beta1, Sma/Mad (Smad) 3, and Smad7 mRNA expression and protein levels in esophageal tissue were detected by means of reverse transcriptase-polymerase chain reaction and Western blotting, respectively. |
6(0,0,1,1) | Details |
| 20193171 | Liu JQ, Hu DH, Zhang ZF, Guan H, She T, Zhang J, Bai XZ: [Effects of interferon-gamma on the transforming growth factor beta/Smad pathway in keloid-derived fibroblasts]. J Clin Invest. 2010 Jan;120(1):290-302. doi: 10.1172/JCI39194. Epub 2009 Dec 1. The expression level of Smad 3 and Smad 7 protein was detected by Western blot before and 1, 2, 4, 6, 8 h post stimulation (PSH). |
6(0,0,0,6) | Details |
| 19955655 | Araki S, Eitel JA, Batuello CN, Bijangi-Vishehsaraei K, Xie XJ, Danielpour D, Pollok KE, Boothman DA, Mayo LD: TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. J Immunol. 2008 Oct 1;181(7):4523-33. In this study, we report that TGF-beta1-activated SMA- and MAD3 (Smad3/4) transcription factors specifically bound to the second promoter region of HDM2, leading to increased HDM2 protein expression and destabilization of p53 in human cancer cell lines. |
1(0,0,0,1) | Details |
| 19376089 | Szuster-Ciesielska A, Plewka K, Daniluk J, Kandefer-Szerszen M: supplementation attenuates - and -induced liver stellate cell activation by inhibiting reactive species (ROS) production and by influencing intracellular signaling. Mol Endocrinol. 2007 Oct;21(10):2472-86. Epub 2007 Jun 26. In - and -induced HSCs, zinc inhibited the activation of the p38 MAPK as well as the JNK transduction pathways and phosphorylation of IkappaB and Smad 3. |
1(0,0,0,1) | Details |