Protein Information

Name INI1
Synonyms BAF47; HSNFS; INI 1; INI1; Integrase interactor 1; Integrase interactor 1 protein; Malignant rhabdoid tumor suppressor; RDT…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18985520 Wu X, Dagar V, Algar E, Muscat A, Bandopadhayay P, Ashley D, Wo Chow C: Rhabdoid tumour: a malignancy of early childhood with variable primary site, histology and clinical behaviour. Pathology. 2008 Dec;40(7):664-70.


Immunohistochemistry for INI1 and molecular investigations for INI1 mutations were performed.
5(0,0,0,5) Details
20123451 Fanburg-Smith JC, Auerbach A, Marwaha JS, Wang Z, Santi M, Judkins AR, Rushing EJ: Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases. Ann Diagn Pathol. 2010 Feb;14(1):8-14. Epub 2009 Dec 8.


INI1 was retained in all tumors studied.
2(0,0,0,2) Details
18369529 Makuria AT, Rushing EJ, McGrail KM, Hartmann DP, Azumi N, Ozdemirli M: Atypical teratoid rhabdoid tumor (AT/RT) in adults: review of four cases. J Neurooncol. 2008 Jul;88(3):321-30. Epub 2008 Mar 28.


Three of the four cases lacked nuclear expression of INI1.
2(0,0,0,2) Details
19216214 Samaras V, Stamatelli A, Samaras E, Stergiou I, Konstantopoulou P, Varsos V, Judkins AR, Biegel JA, Barbatis C: Atypical teratoid/rhabdoid tumor of the central nervous system in an 18-year-old patient. Clin Neuropathol. 2009 Jan-Feb;28(1):1-10.


INI1 immunostaining demonstrated diffuse loss of nuclear INI1 expression in tumor cells.
1(0,0,0,1) Details
19925561 Mohapatra I, Santosh V, Chickabasaviah YT, Mahadevan A, Tandon A, Ghosh A, Chidambaram B, Sampath S, Bhagavatula ID, Chandramouli BA, Kolluri SV, Shankar SK: Histological and immunohistochemical characterization of AT/RT: A report of 15 cases from India. Neuropathology. 2009 Nov 18.


There was lack of INI1 expression in all cases.
1(0,0,0,1) Details