Protein Information

Name Toll like receptor 3
Synonyms CD283; CD283 antigen; TLR 3; TLR3; Toll like receptor 3; Toll like receptor 3 precursor; CD283 antigens; Toll like receptor 3s…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18988918 Sugiura H, Ichikawa T, Koarai A, Yanagisawa S, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Ichinose M: Activation of Toll-like receptor 3 augments myofibroblast differentiation. Am J Respir Cell Mol Biol. 2009 Jun;40(6):654-62. Epub 2008 Nov 6.

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18802055 Al-Salleeh F, Petro TM: Promoter analysis reveals critical roles for SMAD-3 and ATF-2 in expression of IL-23 p19 in macrophages. J Immunol. 2008 Oct 1;181(7):4523-33.

We identified potential binding sites for IFN response factor (IRF)-3 (nt -734 to -731), Sma- and Mad-related protein (SMAD)-3 (nt -584 to -581), activating transcription factor (ATF)-2 (nt -571 to -568), IRF-7 (nt -533 to-525), and NF-kappaB (nt -215 to -209) in the murine p19 promoter.
The p19 (prom) in the pGL3 promoter-reporter vector responded to TMEV or poly (I:C), a TLR3 agonist in the RAW264.7 macrophage cell line.
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