Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18071852 Liu H, Luo Y, Higa M, Zhang X, Saijo Y, Shiraishi Y, Sekine K, Yambe T: Biochemical evaluation of an artificial anal sphincter made from shape memory alloys. J Artif Organs. 2007;10(4):223-7. Epub 2007 Dec 20.


Biochemical parameters including total protein, albumin, total bilirubin, aspartate amino-transferase, blood urea nitrogen, creatinine, and C-reactive protein were examined.
2(0,0,0,2) Details
19388911 Gunduz A, Turkmen S, Turedi S, Mentese A, Yulug E, Ulusoy H, Karahan SC, Topbas M: Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia. Acad Emerg Med. 2009 Jun;16(6):539-43. Epub 2009 Apr 21.

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18272103 Gunduz A, Turedi S, Mentese A, Karahan SC, Hos G, Tatli O, Turan I, Ucar U, Russell RM, Topbas M: Ischemia-modified albumin in the diagnosis of acute mesenteric ischemia: a preliminary study. Am J Emerg Med. 2008 Feb;26(2):202-5.

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17903371 Shi LJ, Li SX, Sun B, Wang JH, Li HL, Jin LH: [Effects of bone marrow mesenchymal stem cells on the proliferation of hepatocytes and cirrhotic fat-storing cells in vitro]. Zhonghua Gan Zang Bing Za Zhi. 2007 Sep;15(9):681-4.


Anti-albumin and anti-smooth muscle alpha-actin (alpha-SMA) antibodies were tested by using fluorescence immunocytochemistry.
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19422480 Jung KH, Shin HP, Lee S, Lim YJ, Hwang SH, Han H, Park HK, Chung JH, Yim SV: Effect of human umbilical cord blood-derived mesenchymal stem cells in a cirrhotic rat model. Liver Int. 2009 Jul;29(6):898-909. Epub 2009 Apr 17.


Interestingly, CM-DiI-labelled HMSCs expressed the hepatocyte-specific markers, human albumin and alpha-fetoprotein.
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20025519 Yu Y, Lv L, Qian X, Chen N, Yao A, Pu LY, Zhang F, Li XC, Kong LB, Sun BC, Wang X: Anti-fibrotic Effect of Hepatocyte Growth Factor-expressing Mesenchymal Stem Cells in Small-for-size Liver Transplant Rats. Stem Cells Dev. 2009 Dec 21.


Fibrosis indexes, including laminin (LN), hyaluronic acid (HA) levels in serum and hydroxyproline (Hyp) content in the liver grsfts, the expression of transforming growth factor-beta1 (TGF-beta1), rat HGF (rHGF), alpha-smooth muscle actin (alpha-SMA) in hepatic stellate cells (HSCs), alanine aminotransferase (ALT), total bilirubin (BIL) and albumin (ALB) levels in serum, in rats in different treatment groups were assessed at different time points.
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17846888 Jaskiewicz K, Rzepko R, Sledzinski Z: Fibrogenesis in fatty liver associated with obesity and diabetes mellitus type 2. Dig Dis Sci. 2008 Mar;53(3):785-8. Epub 2007 Sep 12.


Patients with diabetes were older; had higher BMI, liver enzyme tests, glucose, cholesterol, and triglycerides; and lower albumin concentration.
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17881083 Kajahn J, Gorjup E, Tiede S, von Briesen H, Paus R, Kruse C, Danner S: Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells. Eur J Cell Biol. 2008 Jan;87(1):39-46. Epub 2007 Sep 19.


PGP 9.5+ and GFAP+), mesoderm (e.g. alpha-SMA+) and entoderm (e.g. amylase+ and albumin+).
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19381675 Mansuroglu T, Dudas J, Elmaouhoub A, Joza TZ, Ramadori G: Hepatoblast and mesenchymal cell-specific gene-expression in fetal rat liver and in cultured fetal rat liver cells. Histochem Cell Biol. 2009 Jul;132(1):11-9. Epub 2009 Apr 19.

Albumin and alpha-fetoprotein (AFP) could be detected in the primary cultures and to a lesser extent after the first passage.
SMA-gene-expression increased during the passages, suggesting that myofibroblasts become the major cell population of fetal liver cell cultures over time.
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20052656 Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA: Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology. 2010 Mar;51(3):1027-36.


We bred triple transgenic mice expressing ROSA26 stop beta-galactosidase (beta-gal), albumin Cre, and collagen alpha1 (I) green fluorescent protein (GFP), in which hepatocyte-derived cells are permanently labeled by beta-gal and type I collagen-expressing cells are labeled by GFP.
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19065061 Ren X, Guan G, Liu G, Liu G: Irbesartan ameliorates diabetic nephropathy by reducing the expression of connective tissue growth factor and alpha-smooth-muscle actin in the tubulointerstitium of diabetic rats. Pharmacology. 2009;83(2):80-7. Epub 2008 Dec 9.


At the end of the 16th week, blood glucose, kidney weight/body weight, urine albumin (UAlb) and creatinine clearance rate were determined.
1(0,0,0,1) Details
19670427 Tong Z, Chen R, Alt DS, Kemper S, Perbal B, Brigstock DR: Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes. Hepatology. 2009 Sep;50(3):939-47.


To investigate CCN2 action in vivo, transgenic FVB mice were created in which the human CCN2 gene was placed under the control of the albumin enhancer promoter to elevate hepatocyte CCN2 levels.
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18822912 Wang XB, Liu P, Tang ZP: [Intervening and therapeutic effect of cordyceps mycelia extract on liver cirrhosis induced by dimethylnitrosamine in rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Jul;28(7):617-22.


RESULTS: CME-intervention experiment showed that as compared to those in the modeled rats at corresponding time points, in rats at T1 and T2, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity and total bilirubin (TBIL) content were significantly lower, and albumin (Alb) obviously higher; while at T2, Hyp content, ct-SMA and Col I positive expression were significantly lower (P < 0.05), the proliferation of collagen fibre attenuated.
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18237412 Liu C, Sun M, Wang L, Wang G, Chen G, Liu C, Liu P: Effects of Yinchenhao Tang and related decoctions on DMN-induced cirrhosis/fibrosis in rats. Chin Med. 2008 Jan 31;3:1.


However, the albumin (Alb) level in serum decreased significantly.
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17633368 Gao HY, He XF, Shao JF: [Effect of kurarinone on renal tubular epithelial cell-mesenchyma trans-differentiation in rats with renal interstitial fibrosis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Jun;27(6):535-9.


The serum levels of blood urea nitrogen (BUN), serum creatinine (SCr), total protein (TP) and albumin (ALB), 24-h urinary protein excretion in rats were measured.
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20082249 Chen Y, Chen Q, Lu J, Li FH, Tao YY, Liu CH: Effects of Danggui Buxue Decoction () on lipid peroxidation and MMP-2/9 activities of fibrotic liver in rats. Chin J Integr Med. 2009 Dec;15(6):435-41. Epub 2010 Jan 18.


The liver function including serum alanine aminotransamine (ALT), aspartate transamine (AST), albumin (Alb) and total bilirubin (TBIL), liver triglyceride (TG) and malondialdehyde (MDA) contents, superoxide dismutase (SOD) activity were assayed.
1(0,0,0,1) Details