Protein Information

Name JAK2
Synonyms JAK 2; JAK2; JAK2 protein; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); Tyrosine protein kinase 2; Tyrosine protein kinase JAK2; JAK2 proteins…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19781194 Jiang T, Zhou QS, Pi L, Huang B: [Role of angiotensin II and JAK2 signal pathway in transdifferentation of renal tubular cells in mice after acute ischemic followed by reperfusion]. Zhonghua Bing Li Xue Za Zhi. 2009 Jul;38(7):466-71.

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18035585 Yu JH, Kim KH, Kim H: SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas. Int J Biochem Cell Biol. 2008;40(4):677-88. Epub 2007 Oct 12.

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17823504 Li R, Yang N, Zhang L, Huang Y, Zhang R, Wang F, Luo M, Liang Y, Yu X: Inhibition of Jak/STAT signaling ameliorates mice experimental nephrotic syndrome. Am J Nephrol. 2007;27(6):580-9. Epub 2007 Sep 6.


In the second study, treatment with the selective JAK2 inhibitor AG490 (15 mg/kg, q.d., i.p.) or vehicle was started 5 days after adriamycin injection.
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17633463 Zhang MZ, Zhang MY, Zhao S, Duan JZ, Zhang YQ, Zuo CX, Cheng XY, Duan HJ: [Effect of JAK/STAT pathway activation on high glucose-induced transdifferentiation in renal proximal tubular epithelial cells]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007 Jun;29(3):364-9.


Immunoprecipitation and Western blot analysis were used to determine the expression of tryosine phosphorylated Janus kinase 2 ( p-JAK2).
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19350281 Liang Y, Jin Y, Li Y: Expression of JAKs/STATs pathway molecules in rat model of rapid focal segmental glomerulosclerosis. Pediatr Nephrol. 2009 Sep;24(9):1661-71. Epub 2009 Apr 7.


The expressions of JAK1, JAK2, STAT1, STAT3, suppressors of cytokine signaling (SOCS) 1, SOCS3, protein inhibitors of activated STAT (PIAS) 1, and PIAS3 were also measured by real-time quantitative reverse transcriptase-PCR.
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