Protein Information

Name Ki 67
Synonyms Antigen KI 67; Antigen identified by monoclonal antibody Ki 67; KIA; Ki 67; MKI67; Proliferation related Ki 67 antigen; Antigen identified by monoclonal antibody Ki 67s; Ki 67s…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19093260 Hornychova H, Melichar B, Tomsova M, Mergancova J, Urminska H, Ryska A: Tumor-infiltrating lymphocytes predict response to neoadjuvant chemotherapy in patients with breast carcinoma. Cancer Invest. 2008 Dec;26(10):1024-31.

In the remaining 63 patients, a significant decrease in the percentage of Ki-67, vascular endothelial growth factor expression, CD68 (+) monocytes, and increased CD31 (+), CD34 (+), and SMA (+) stromal vessels, maximal CD3 (+) and CD56 (+) lymphocyte, maximal and mean CD83 (+) cell, maximal CD1a (+), and maximal and mean S100 (+) cell counts were observed after neoadjuvant chemotherapy.
6(0,0,1,1) Details
20013263 Knosel T, Schulz B, Katenkamp K, Katenkamp D, Petersen I: [Solitary fibrous tumor and haemangiopericytoma: what is new?] . Pathologe. 2010 Mar;31(2):123-8.

In this study 268 intrathoracic and extrathoracic SFTs from the German consultation and reference center of soft tissue tumors in Jena were evaluated and analyzed immunohistochemically with antibodies CD34, Bcl-2, CD99, SMA, S100, PanCK and Ki-67.
6(0,0,1,1) Details
18505417 Ji F, Wang ZW, Wang LJ, Ning JW, Xu GQ: Clinicopathological characteristics of gastrointestinal mesenchymal tumors and diagnostic value of endoscopic ultrasonography. J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e318-24. Epub 2008 May 26.


The expression of CD117, CD34, smooth muscle actin (SMA), S-100, and Ki-67 were detected using immunohistochemistry.
3(0,0,0,3) Details
20340130 Vered M, Dayan D, Yahalom R, Dobriyan A, Barshack I, Bello IO, Kantola S, Salo T: Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma. Int J Cancer. 2010 Mar 25.


Triple immunostaining in RLNs was used to highlight the carcinoma cells (E-cadherin and Ki-67) and their relationship to the CAFs (alpha-SMA).We found that metastatic RLNs hosted CAFs similarly as in pair-matched primary tumors.
2(0,0,0,2) Details
18949416 Tai WC, Chuah SK, Lin JW, Chen HH, Huang HY, Kuo CM, Yi LN, Lee CM, Changchien CS, Hu TH: Colorectal mesenchymal tumors - from smooth muscle tumors to stromal tumors. Oncol Rep. 2008 Nov;20(5):1157-64.


Immunohistochemical studies were performed with antibodies of CD117, CD34, smooth muscle actin (SMA), desmin, S-100, Ki-67 and PCNA for clinicopathologic and prognostic correlation.
2(0,0,0,2) Details
17672376 Ozcan A, Karslioglu Y, Kurt B, Onguru O, Gunhan O: Quantitative evaluation of immunohistochemical staining in gastrointestinal stromal tumors. Anal Quant Cytol Histol. 2007 Jun;29(3):159-65.


RESULTS: All GISTs showed some degree of expression of CD 117, CD34, SMA and Ki-67.
2(0,0,0,2) Details
19952797 Liu ZJ, Zhang LJ, Zhao Q, Li QW, Wang EB, Ji SJ, Shu H: Pediatric synovial sarcoma of the sacrum: a case report. J Pediatr Orthop B. 2010 Mar;19(2):207-10.


CK, CK7, CK1, CK3, CK8, CK19, Bcl-2, E-cadherin, ki-67, P53, SMA, CD99, CD56, S-100, vimentin, and epithelial membrane antigen were positive.
2(0,0,0,2) Details
19907023 Hindman HB, Swanton JN, Phipps RP, Sime PJ, Huxlin KR: Differences in the TGF-{beta}1-induced profibrotic response of anterior and posterior corneal keratocytes in vitro. Invest Ophthalmol Vis Sci. 2010 Apr;51(4):1935-42. Epub 2009 Nov 11.


Using immunohistochemistry and Western blot techniques, Ki-67 staining and relative expression of Thy-1, alpha smooth muscle actin (alpha-SMA), and fibronectin were assessed after stimulation with different TGF-beta1 concentrations.
2(0,0,0,2) Details
19150605 Bello IO, Alanen K, Slootweg PJ, Salo T: Alpha-smooth muscle actin within epithelial islands is predictive of ameloblastic carcinoma. Oral Oncol. 2009 Sep;45(9):760-5. Epub 2009 Jan 16.


We examined immunohistochemically Ki-67, epithelial membrane antigen (EMA), alpha-smooth muscle actin (alpha-SMA), calponin, p63 and DNA content using image (ICM) and flow cytometry (FCM) in three ameloblastic carcinomas and up to 18 SAs.
1(0,0,0,1) Details
17674035 Budny T, Palmes D, Stratmann U, Minin E, Herbst H, Spiegel HU: Morphologic features in the regenerating liver--a comparative intravital, lightmicroscopical and ultrastructural analysis with focus on hepatic stellate cells. Virchows Arch. 2007 Oct;451(4):781-91. Epub 2007 Aug 3.


Morphological features were investigated by light microscopy, immunohistochemistry [alpha-smooth muscle actin (alpha-SMA), Desmin, vascular endothelial growth factor (VEGF)/VEGF receptor, Ki-67, ssDNA], intravital microscopy (sinusoid density, number of hepatocytes, and HSC), and electron microscopy focussed on cell-to-cell interactions.
1(0,0,0,1) Details
20025456 Dalakas E, Newsome PN, Boyle S, Brown R, Pryde A, McCall S, Hayes PC, Bickmore W, Harrison DJ, Plevris JN: Bone Marrow Stem Cells Contribute to Alcohol Liver Fibrosis in Humans. Stem Cells Dev. 2009 Dec 21.


Y-chromosome analysis was performed, along with co-staining for hepatocyte, biliary, myofibroblast and Ki-67 markers.
1(0,0,0,1) Details
19085956 Asahina K, Tsai SY, Li P, Ishii M, Maxson RE Jr, Sucov HM, Tsukamoto H: Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009 Mar;49(3):998-1011.


Ki-67 staining showed that proliferative activity of the submesothelial cells is higher than that of mesothelial cells and transitional cells.
1(0,0,0,1) Details
18579759 He J, Bazan HE: Epidermal growth factor synergism with TGF-beta1 via PI-3 kinase activity in corneal keratocyte differentiation. Invest Ophthalmol Vis Sci. 2008 Jul;49(7):2936-45.


Cell proliferation was evaluated with anti-Ki-67 antibody.
1(0,0,0,1) Details
19288266 Grande MT, Arevalo M, Nunez A, Cannata-Andia JB, Santos E, Lopez-Novoa JM: Targeted genomic disruption of H-ras and N-ras has no effect on early renal changes after unilateral ureteral ligation. World J Urol. 2009 Mar 15.


Fibronectin, alpha-smooth muscle actin, cleaved caspase-3, ki-67, Ras-GTP, pERK, and pAkt expression was analyzed by western blot and/or immunohistochemistry.
1(0,0,0,1) Details
20021609 Kwon MJ, Nam ES, Cho SJ, Park HR, Shin HS, Park JH, Park CH, Lee WJ: Comparison of tissue microarray and full section in immunohistochemistry of gastrointestinal stromal tumors. Pathol Int. 2009 Dec;59(12):851-6.


Six primary antibody markers (c-Kit, CD34, smooth muscle actin (SMA), S-100, p53, and Ki-67) were used with the TMA technique to analyze 0.6 mm, 2 mm, and 3 mm punch cores of GIST samples from 67 patients.
1(0,0,0,1) Details
18021353 Lavranos G, Paschalis G, Angelopoulou R, Karandrea D, Goutas N: Casual discovery of a thoracic tumour showing histological features of undifferentiated pleomorphic sarcoma in a male Wistar laboratory rat. Anat Histol Embryol. 2007 Dec;36(6):433-6.


Immunohistochemistry was performed on the tissue using specific antibodies for several proliferation (Ki-67) and differentiation (S-100, CD-34, CD-68, pan-keratin, desmin and smooth muscle actin-SMA) markers.
1(0,0,0,1) Details
19272803 Nishioka M, Aguirre RL, Ishikawa A, Nagumo K, Wang LH, Okada N: Nerve sheath myxoma (neurothekeoma) arising in the oral cavity: histological and immunohistochemical features of 3 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 May;107(5):e28-33. Epub 2009 Mar 9.


The number of Ki-67 positive cells was less than 5% in all lesions confirming the slow growing characteristics of NSM.
1(0,0,0,1) Details
17923411 Schachner T, Steger C, Heiss S, Bonaros N, Sterlacci W, Laufer G, Bonatti J: Paclitaxel treatment reduces neointimal hyperplasia in cultured human saphenous veins. Eur J Cardiothorac Surg. 2007 Dec;32(6):906-11. Epub 2007 Oct 17.


The proliferation marker ki-67 was occasionally present in the circumferential media, whereas it was almost absent in both the (inner) longitudinal media and the intima.
1(0,0,0,1) Details