Protein Information

Name apoprotein
Synonyms AD2; APOE; Apo E; Apolipoprotein E; Apolipoprotein E precursor; apoprotein; Apo Es; Apolipoprotein Es…

Compound Information

Name ferrous sulfate
CAS sulfuric acid iron(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
7840815 Fuhrman B, Oiknine J, Aviram M: Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties. Atherosclerosis. 1994 Nov;111(1):65-78.


Macrophage lipid peroxidation increases cell-mediated oxidation of LDL, enhances the release of interleukin 1 and inhibits the release of apolipoprotein E from the macrophages.
2(0,0,0,2) Details
3985629 Gregory EM: Characterization of the O2-induced manganese-containing superoxide dismutase from Bacteroides fragilis. Arch Biochem Biophys. 1985 Apr;238(1):83-9.


Dialysis of the denatured apoprotein in buffer containing either Fe (NH4) 2 (SO4) 2 or MnCl2 restored O2-. scavenging activity.
3(0,0,0,3) Details
2127939 Nasr-Esfahani M, Johnson MH, Aitken RJ: The effect of iron and iron chelators on the in-vitro block to development of the mouse preimplantation embryo: BAT6 a new medium for improved culture of mouse embryos in vitro. Hum Reprod. 1990 Nov;5(8):997-1003.


The high affinity iron chelator, desferal, also blocked development, whilst transferrin (whether as apoprotein or saturated with iron), DETAPAC and EDTA promoted development.
1(0,0,0,1) Details
10881261 Tamaoka A, Miyatake F, Matsuno S, Ishii K, Nagase S, Sahara N, Ono S, Mori H, Wakabayashi K, Tsuji S, Takahashi H, Shoji S: Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease. Neurology. 2000 Jun 27;54(12):2319-21.

2(0,0,0,2) Details
10424464 Kashiwagi S, Nakamura K, Arai H, Yamashita H, Ito H: Electrophoretic analysis of oxidative modification of apolipoprotein E in very low density lipoprotein from fresh human plasma. Electrophoresis. 1999 Jun;20(7):1418-24.

1(0,0,0,1) Details