Protein Information

Name glutathione reductase
Synonyms GLUR; GR; GRD 1; GRD1; GRase; GSR; Glutathione reductase; GRases…

Compound Information

Name ferrous sulfate
CAS sulfuric acid iron(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
10914467 Tomeckova V, Barnova E, Guzy J, Chavkova Z, Marekova M, Dubayova K, Kusnir J: [Fe2+-induced oxidative processes in the liver mitochondria of rats] . Bratisl Lek Listy. 2000;101(4):213-8.


The study included the investigation of consumption of oxygen in state 4 (without ADP addition) and in state 3 (with ADP addition), and the activities of ATP-ase, superoxide dismutase (SOD) and glutathione reductase.
4(0,0,0,4) Details
9482049 Im MJ, Winograd JM, Manson PN, Vander Kolk CA: Iron-induced rat coronal suture fusion in vitro: the role of redox regulation. J Craniofac Surg. 1997 Jul;8(4):262-9.


The enzymes assayed were hexokinase (HK) and pyruvate kinase (PK) of glycolysis, and glucose 6-phosphate dehydrogenase (G6PD) and glutathione reductase (GR) of the antioxidative pathway.
1(0,0,0,1) Details
12916070 Thirunavukkarasu V, Anuradha CV, Viswanathan P: Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity. Phytother Res. 2003 Aug;17(7):737-43.


Significantly lower activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and glutathione reductase were observed in liver and brain accompanied by depletion in glutathione, ascorbic acid and alpha-tocopherol concentrations.
1(0,0,0,1) Details
16140208 Duarte AI, Santos MS, Oliveira CR, Rego AC: Insulin neuroprotection against oxidative stress in cortical neurons--involvement of uric acid and glutathione antioxidant defenses. Free Radic Biol Med. 2005 Oct 1;39(7):876-89.


Moreover, insulin stimulated glutathione reductase (GRed) and inhibited glutathione peroxidase (GPx) activities under oxidative stress conditions, further supporting that insulin neuroprotection was related to the modulation of the glutathione redox cycle.
1(0,0,0,1) Details
2516241 Srivastava SK, Ansari NH, Liu S, Izban A, Das B, Szabo G, Bhatnagar A: The effect of oxidants on biomembranes and cellular metabolism. . Mol Cell Biochem. 1989 Nov 23-Dec 19;91(1-2):149-57.

Since NADPH is also aldose required by glutathione reductase for reducing oxidants, its diversion would lead to membrane lipid oxidation and permeability changes which are probably responsible for diabetic complications such as cataractogenesis, retinopathy, neuropathy etc.
By using patch-clamp technique in isolated frog myocytes, we have shown that hydroxy radicals generated by ferrous sulfate and ascorbate as well as lipid peroxides such as t-butyl hydroperoxide facilitate the entry of Na+ by oxidizing Na+-channels.
1(0,0,0,1) Details