| Name | hemoglobin (protein family or complex) |
|---|---|
| Synonyms | Hemoglobin; Hemoglobins |
| Name | potassium cyanate |
|---|---|
| CAS | potassium cyanate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6412992 | Feo CJ, Johnson RM, Nossal M: [Effects of 3 varieties of antisickling substances measured by ektacytometry as a function of pressure]. C R Seances Acad Sci III. 1983;296(19):911-6. Drugs representative of the three modes of action presently recognized have been selected: those which increase affinity (potassium cyanate); those which inhibit hemoglobin polymerization (butylurea); membrane-active compounds. |
81(1,1,1,1) | Details |
| 846010 | Winston JM, Roberts RJ: Effect of potassium cyanate on and hypoxic hypoxia-induced lethality. J Toxicol Environ Health. 1977 Jan;2(3):625-31. Pretreatment of mice with potassium cyanate for 15 days resulted in a significant increase in hemoglobin- affinity (decrease in P 50) and a significant protection against hypoxic hypoxia-induced lethality. |
33(0,1,1,3) | Details |
| 4748508 | Woodson RD, Wranne B, Detter JC: Effect of increased blood affinity on work performance of rats. J Clin Invest. 1973 Nov;52(11):2717-24. Modification of blood affinity was achieved both by 2,3- depletion, accomplished by exposure of animals to CO (2) and by exchange transfusion with blood exposed to or stored in acid and by carbamylation of hemoglobin, produced by exchange transfusion of blood incubated with potassium cyanate. |
33(0,1,1,3) | Details |
| 3615491 | Roth EF Jr, Wenz B, Lee HB, Fabry M, Chang H, Kaul DK, Baez S, Nagel RL: Survival rates and properties of sickle cell anemia red cells treated with nitrogen mustard. Prog Clin Biol Res. 1987;240:245-61. Solubility determination (Csat) of deoxy hemoglobin S gels demonstrated that HN2 markedly inhibited the polymerization of HbS, was significantly more effective than potassium cyanate, and is among the most potent anti-sickling agents thus far reported. |
31(0,1,1,1) | Details |
| 977566 | Lee CK: Methylisocyanate as an antisickling agent and its reaction with hemoglobin S. J Biol Chem. 1976 Oct 25;251(20):6226-31. Reviewing the reaction of potassium cyanate, an antisickling agent, with alpha-amino groups of hemoglobin, it was found that the reaction was a slow process and requires a large excess of the reagent. |
13(0,0,1,8) | Details |
| 1990974 | Claster S, White E, Woolworth V, Quintanilha A: Degradation of erythrocyte glycophorin results in increased membrane bound hemoglobin. Arch Biochem Biophys. 1991 Feb 15;285(1):147-52. |
7(0,0,0,7) | Details |
| 5288366 | Cerami A, Manning JM: Potassium cyanate as an inhibitor of the sickling of erythrocytes in vitro. Proc Natl Acad Sci U S A. 1971 Jun;68(6):1180-3. The prevention of sickling is a function of the amount of [(14) C] incorporated into acidprecipitable protein (0.1-1.0 mol of per mol of hemoglobin). |
2(0,0,0,2) | Details |
| 6338971 | Chang H, Ewert SM, Bookchin RM, Nagel RL: Comparative evaluation of fifteen anti-sickling agents. Blood. 1983 Apr;61(4):693-704. These tests included (1) the determination of the solubility of deoxyhemoglobin S or Csat, (2) evaluation of sickling in whole SS blood at various pO2s, (3) measurement of the affinity of hemoglobin and blood, and (4) examination of red cell indices and morphology. |
1(0,0,0,1) | Details |
| 9078546 | Mock DM, Strauss RG, Lankford GL: [14C] labeling of sheep red cells: covalent binding to hemoglobin continues in vivo for a day. Pediatr Res. 1997 Mar;41(3):424-9. |
1(0,0,0,1) | Details |