Protein Information

Name sulfotransferase
Synonyms SULT; sulfotransferase

Compound Information

Name sulfuric acid
CAS sulfuric acid

Reference List

PubMed Abstract RScore(About this table)
15281911 Schneider H, Glatt H: Sulpho-conjugation of ethanol in humans in vivo and by individual sulphotransferase forms in vitro. Biochem J. 2004 Nov 1;383(Pt. 3):543-9.


We studied whether ethanol is sulphonated in humans with the perspective of using the urinary excretion of ethyl sulphate after ethanol consumption as a biomarker for SULT (sulphotransferase) activity.
3(0,0,0,3) Details
11950791 Meloche CA, Sharma V, Swedmark S, Andersson P, Falany CN: Sulfation of budesonide by human cytosolic sulfotransferase, dehydroepiandrosterone-sulfotransferase (DHEA-ST). Drug Metab Dispos. 2002 May;30(5):582-5.

1(0,0,0,1) Details
12464797 Meinl W, Meerman JH, Glatt H: Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium. Pharmacogenetics. 2002 Dec;12(9):677-89.

Whereas OH-AAF and OH-APP showed the highest mutagenic activities in strains expressing SULT1A2, 1-HMP was more potent in strains expressing other SULT forms.
Various enzymatically formed sulfuric acid esters are chemically reactive and mutagenic.
1(0,0,0,1) Details
16966419 Kamimura K, Koyama T, Habuchi H, Ueda R, Masu M, Kimata K, Nakato H: Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling. J Cell Biol. 2006 Sep 11;174(6):773-8.


To clarify the in vivo importance of HS fine structures, we characterized the functions of the Drosophila HS 2-O and 6-O sulfotransferase (Hs2st and Hs6st) genes in FGF-mediated tracheal formation.
1(0,0,0,1) Details
14570471 Burlingham BT, Pratt LM, Davidson ER, Shiner VJ Jr, Fong J, Widlanski TS: 34S isotope effect on sulfate ester hydrolysis: mechanistic implications. J Am Chem Soc. 2003 Oct 29;125(43):13036-7.


The isotope effect method we report should also prove useful for studying the mechanism of other sulfuryl group transfers, including sulfatase and sulfotransferase reactions, as well as sulfate hydrolyses under other conditions.
1(0,0,0,1) Details
18815351 Senggunprai L, Yoshinari K, Shimada M, Yamazoe Y: Involvement of ST1B subfamily of cytosolic sulfotransferase in kynurenine metabolism to form natriuretic xanthurenic acid sulfate. J Pharmacol Exp Ther. 2008 Dec;327(3):789-98. Epub 2008 Sep 24.

1(0,0,0,1) Details
14754874 Glatt H, Meinl W: Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of sulfotransferases and acetyltransferases in nitrofen mutagenicity. Carcinogenesis. 2004 May;25(5):779-86. Epub 2004 Jan 30.


Nitrofen is a nitroarene and as such might be activated to a mutagen via reduction to the corresponding hydroxylamine and subsequent formation of a reactive acetic or sulfuric acid ester.
0(0,0,0,0) Details