Protein Information

Name thrombin
Synonyms Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin…

Compound Information

Name sulfuric acid
CAS sulfuric acid

Reference List

PubMed Abstract RScore(About this table)
18558097 Melo FR, Pereira MS, Monteiro RQ, Foguel D, Mourao PA: Sulfated galactan is a catalyst of antithrombin-mediated inactivation of alpha-thrombin. Biochim Biophys Acta. 2008 Sep;1780(9):1047-53. Epub 2008 May 28.

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15590773 Pomin VH, Pereira MS, Valente AP, Tollefsen DM, Pavao MS, Mourao PA: Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity. Glycobiology. 2005 Apr;15(4):369-81. Epub 2004 Dec 8.


A linear sulfated fucan with a regular repeating sequence of [3)-alpha-L-Fucp-(2SO4)-(1--> 3)-alpha-L-Fucp-(4SO4)-(1--> 3)-alpha-L-Fucp-( 2,4SO4)-(1--> 3)-alpha-L-Fucp-(2SO4)-(1-->] n is an anticoagulant polysaccharide mainly due to thrombin inhibition mediated by heparin cofactor II.
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16102810 Han F, Yao W, Yang X, Liu X, Gao X: Experimental study on anticoagulant and antiplatelet aggregation activity of a chemically sulfated marine polysaccharide YCP. Int J Biol Macromol. 2005 Sep 15;36(4):201-7.


Anticoagulant activity and antiplatelet aggregation activity of these sulfated derivates were evaluated by activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and platelet aggregation assay.
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19473428 Negoro S, Tanaka A, Takikawa H: Urinary bile acid sulfate levels in patients with hepatitis C virus-related chronic liver diseases. Hepatol Res. 2009 Aug;39(8):760-5. Epub 2009 Apr 3.

Aim: Urinary bile acids are mainly conjugated with sulfuric acid, and urinary sulfated bile acid (USBA) levels in hepatobiliary diseases have been reported.
USBA level was well correlated with TBA (r (s) = 0.680), and negatively correlated with albumin (r (s) = -0.488), prothrombin time (r (s) = -0.385) and platelet counts (r (s) = -0.394).
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