Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name sulfuric acid
CAS sulfuric acid

Reference List

PubMed Abstract RScore(About this table)
12458705 Diaz-Gonzalez M, Fernandez-Sanchez C, Costa-Garcia A: Indirect determination of alkaline phosphatase based on the amperometric detection of indigo carmine at a screen-printed electrode in a flow system. Anal Sci. 2002 Nov;18(11):1209-13.

This product is insoluble in aqueous solutions but it was easily converted into its soluble parent compound, indigo carmine, by addition of fuming sulfuric acid to the reaction media.
2(0,0,0,2) Details
15382915 Nikolic-Hughes I, Rees DC, Herschlag D: Do electrostatic interactions with positively charged active site groups tighten the transition state for enzymatic phosphoryl transfer?. J Am Chem Soc. 2004 Sep 29;126(38):11814-9.


In this work, we investigate the transition state for alkaline phosphatase (AP) using linear free-energy relationships (LFERs).
1(0,0,0,1) Details
18809363 Helary G, Noirclere F, Mayingi J, Migonney V: A new approach to graft bioactive polymer on titanium implants: Improvement of MG 63 cell differentiation onto this coating. Acta Biomater. 2009 Jan;5(1):124-33. Epub 2008 Aug 28.

Cell adhesion, alkaline phosphatase activity and calcium nodules formation were significantly enhanced on grafted titanium samples compared to unmodified surfaces.
Treatment of the titanium surface by a mixture of sulfuric acid and hydrogen peroxide allows the formation of titanium hydroxide and titanium peroxide.
1(0,0,0,1) Details
17031821 de Oliveira PT, Zalzal SF, Beloti MM, Rosa AL, Nanci A: Enhancement of in vitro osteogenesis on titanium by chemically produced nanotopography. J Biomed Mater Res A. 2007 Mar 1;80(3):554-64.


Alkaline phosphatase activity peaked earlier and cell number was higher as of day 7 on the nanopatterned discs.
1(0,0,0,1) Details
15691900 Zwart SR, Davis-Street JE, Paddon-Jones D, Ferrando AA, Wolfe RR, Smith SM: Amino acid supplementation alters bone metabolism during simulated weightlessness. J Appl Physiol. 2005 Jul;99(1):134-40. Epub 2005 Feb 3.

Foods or supplements with excess sulfur-containing amino acids increase endogenous sulfuric acid production and therefore have the potential to increase calcium excretion and alter bone metabolism.
Bone-specific alkaline phosphatase was measured in serum samples collected on day 1 (immediately before bed rest) and on day 28.
1(0,0,0,1) Details