| 15276331 |
Longo V, Marini S, Salvetti A, Angelucci S, Bucci S, Gervasi PG: Effects of beta-naphthoflavone, phenobarbital and dichlobenil on the drug-metabolizing system of liver and nasal mucosa of Italian water frogs. Aquat Toxicol. 2004 Aug 25;69(3):259-70.
The pretreatment with metyrapone, a CYP inhibitor, protected the CYP2A apoprotein and its linked activities from toxic effect of dichlobenil indicating a key role of this enzyme in the bioactivation of this herbicide. |
89(1,1,2,4) |
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| 8378937 |
Walters E, Buchheit K, Maruniak JA: Olfactory cytochrome P-450 immunoreactivity in mice is altered by dichlobenil but preserved by metyrapone. Toxicology. 1993 Jul 28;81(2):113-22.
Antibodies to cytochromes P-450NMa and P-450NMb (CYP2A and CYP2G1, respectively) (P-450 nomenclature by Nebert et al., DNA Cell Biol. 10, 1- (1-14) 14, 1991) were used to assess the effects of the herbicide dichlobenil on the distribution of these olfactory-specific isozymes in the olfactory mucosa. |
6(0,0,1,1) |
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