| Name | cytochrome P450 2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | dichlobenil |
|---|---|
| CAS | 2,6-dichlorobenzonitrile |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7728893 | Deamer NJ, Genter MB: Olfactory toxicity of diethyldithiocarbamate (DDTC) and disulfiram and the protective effect of DDTC against the olfactory toxicity of dichlobenil. Chem Biol Interact. 1995 Apr 14;95(3):215-26. Whereas the results of the mouse study strengthen the hypothesis that dichlobenil is bioactivated to a toxic metabolite by cytochrome P450 2E1 in the C57B1 mouse, rats pretreated with a marginally toxic dose of DDTC prior to the administration of IDPN displayed olfactory mucosal damage, indicating that an alternative or additional pathway may be operative in the metabolism of IDPN and/or DDTC. |
88(1,1,2,3) | Details |
| 16221755 | Franzen A, Carlsson C, Hermansson V, Lang M, Brittebo EB: CYP2A5-mediated activation and early ultrastructural changes in the olfactory mucosa: studies on 2,6-dichlorophenyl methylsulfone. Drug Metab Dispos. 2006 Jan;34(1):61-8. Epub 2005 Oct 12. A high covalent binding of 2,6-diClPh-14C-MeSO2 in olfactory mucosa S9 fraction was observed, and the CYP2A5/CYP2G1 substrates and dichlobenil significantly decreased the binding, whereas the CYP2E1 substrate chlorzoxazone had no effects. |
0(0,0,0,0) | Details |