Protein Information

Name follicle stimulating hormone (protein family or complex)
Synonyms Follicle stimulating hormone; Follitropin; Follitropins

Compound Information

Name DMPA
CAS

Reference List

PubMed Abstract RScore(About this table)
16895950 Matthiesson KL, McLachlan RI, O'Donnell L, Frydenberg M, Robertson DM, Stanton PG, Meachem SJ: The relative roles of follicle-stimulating hormone and luteinizing hormone in maintaining spermatogonial maturation and spermiation in normal men. J Clin Endocrinol Metab. 2006 Oct;91(10):3962-9. Epub 2006 Aug 8.

INTERVENTIONS: Subjects (n = 6/group) were assigned to 6 wk of 1) testosterone (T) implant (4 x 200 mg sc once)+depot medroxy progesterone acetate (DMPA; 150 mg im once); 2) T implant+DMPA+FSH (300 IU sc twice weekly); and 3) T implant+DMPA+human chorionic gonadotropin (hCG; 1000 IU sc twice weekly as an LH substitute).
1(0,0,0,1) Details
15722065 Beksinska ME, Smit JA, Kleinschmidt I, Farley TM, Mbatha F: Bone mineral density in women aged 40-49 years using depot-medroxyprogesterone acetate, norethisterone enanthate or combined oral contraceptives for contraception. Contraception. 2005 Mar;71(3):170-5.

Follicle-stimulating hormone (FSH) level > or=25.8 mIU/mL was associated with a decrease of 0.017 g/cm2 in radius BMD relative to women with FSH <25.8 mIU/mL.
Most studies show that depot-medroxyprogesterone acetate (DMPA) has a negative effect on bone mass.
1(0,0,0,1) Details
12316139 Abdel-sayed WS, Toppozada HK, Said SA, El-sayed OK: Some metabolic and hormonal changes in women using long acting injectable contraceptives. Alex J Pharm Sci. 1989 Mar;3(1):29-32.

Statistically significant suppression of the estimated hormones, Follitropin, Luteotropin, and Estradiol-17beta were detected in both groups of NET/EN and DMPA users, after 6 and 12 months, as compared with the preinjection values.
31(0,1,1,1) Details
14636937 Beksinska ME, Smit JA, Kleinschmidt I, Rees HV, Farley TM, Guidozzi F: Detection of raised FSH levels among older women using depomedroxyprogesterone acetate and norethisterone enanthate. Contraception. 2003 Nov;68(5):339-43.

The objective of this study was to investigate whether follicle-stimulating hormone (FSH) levels can be used reliably to indicate approaching menopause in older (aged 40-49), long-term users of depomedroxyprogesterone acetate (DMPA) and norethisterone enanthate (NET-EN).
6(0,0,1,1) Details
17900438 Juliato CT, Fernandes A, Marchi NM, Castro S, Olivotti B, Bahamondes L: Usefulness of FSH measurements for determining menopause in long-term users of depot medroxyprogesterone acetate over 40 years of age. Contraception. 2007 Oct;76(4):282-6. Epub 2007 Aug 9.

OBJECTIVE: To assess the usefulness of follicle-stimulating hormone (FSH) measurements for determining menopause in 40-55-year-old users of depot medroxyprogesterone acetate (DMPA).
6(0,0,1,1) Details
15639696 Toh YC, Jain J, Rahnny MH, Bode FR, Ross D: Suppression of ovulation by a new subcutaneous depot medroxyprogesterone acetate (104 mg/0.65 mL) contraceptive formulation in Asian women. Clin Ther. 2004 Nov;26(11):1845-54.

BACKGROUND: A new progestin-only, nondaily depot medroxyprogesterone acetate (DMPA) SC injectable contraceptive suspension (104 mg/0.65 mL) has been developed.
Serum concentrations of MPA, progesterone, estradiol, luteinizing hormone, and follicle-stimulating hormone were measured during the 91-day dosing interval and for an additional 15 days thereafter.
1(0,0,0,1) Details
6234145 Lan PT, Aedo AR, Landgren BM, Johannisson E, Diczfalusy E: Return of ovulation following a single injection of depo-medroxyprogesterone acetate: a pharmacokinetic and pharmacodynamic study. Contraception. 1984 Jan;29(1):1-18.

The effect of a single dose of 150 mg of depo-medroxyprogesterone acetate (DMPA) on pituitary, ovarian and endometrial function was assessed in relation to the peripheral levels of the compound in 8 women.
The levels of medroxyprogesterone acetate (MPA), follitropin (FSH), lutropin (LH), prolactin, estradiol (E2) and progesterone ( Prog .) were measured 3 times a week during a pretreatment (control) cycle and then daily during postinjection weeks 14-17, 22-25 and 30-33.
1(0,0,0,1) Details
3159547 Friedl KE, Plymate SR, Paulsen CA: Transient reduction in serum HDL-cholesterol following medroxyprogesterone acetate and testosterone cypionate administration to healthy men. Contraception. 1985 Apr;31(4):409-20.

Serum testosterone (T), estradiol, and sex hormone binding globulin (SHBG), luteinizing hormone (LH), and follicle stimulating hormone (FSH) concentrations were all significantly depressed during the drug administration period.
Serum lipids were examined in thirty normal male volunteers who had received depo-medroxyprogesterone acetate (DMPA) and testosterone cypionate (TC) in a male contraceptive trial.
1(0,0,0,1) Details
8899256 Virutamasen P, Leepipatpaiboon S, Kriengsinyot R, Vichaidith P, Muia PN, Sekadde-Kigondu CB, Mati JK, Forest MG, Dikkeschei LD, Wolthers BG, d'Arcangues C: Pharmacodynamic effects of depot-medroxyprogesterone acetate (DMPA) administered to lactating women on their male infants. Contraception. 1996 Sep;54(3):153-7.

Urinary follicle stimulating hormone (FSH), luteinizing hormone (LH), unconjugated testosterone, and unconjugated cortisol were measured by radioimmunoassay, and serum MPA and urinary MPA metabolites were measured by gas chromatography-mass spectrometry (GC-MS).
1(0,0,0,1) Details
8725700 Mishell DR Jr: Pharmacokinetics of depot medroxyprogesterone acetate contraception. J Reprod Med. 1996 May;41(5 Suppl):381-90.

Depot medroxyprogesterone acetate (DMPA) is an aqueous suspension of 17-acetoxy 6-methyl progestin administered by intramuscular injection for long-term contraception.
The circulating MPA initially inhibits the midcycle leutinizing hormone (LH) peak, but LH and follicle stimulating hormone (FSH) levels remain in the range of those for the luteal phase of a pretreatment control cycle.
1(0,0,0,1) Details